Delay discounting predicts COVID-19 vaccine booster willingness by Julia G. Halilova, Samuel Fynes‑Clinton, Caitlin M. Terao, Donna Rose Addis, R. Shayna Rosenbaum

“…Abstract Developing ways to predict and encourage vaccine booster uptake are necessary for durable immunity responses. In a multi-nation sample, recruited in June–August 2021, we assessed delay discounting (one’s tendency to choose smaller immediate rewards over larger future rewards), COVID-19 vaccination status, demographics, and distress level. …”
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WALDENSTRÖM MACROGLOBULINEMIA - A STATE-OF-THE-ART REVIEW: PART 1: EPIDEMIOLOGY, PATHOGENESIS, CLINICOPATHOLOGIC CHARACTERISTICS, DIFFERENTIAL DIAGNOSIS, RISK STRATIFICATION, AND C... by Michele Bibas, Shayna Sarosiek, Jorge J. Castillo

“…The direct invasion of the malignant cells into tissues like lymph nodes and spleen, along with the immune response related to IgM, can also lead to various health complications, such as cytopenias, hyperviscosity, peripheral neuropathy, amyloidosis, and Bing-Neel syndrome. …”
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Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma by Xue Wang, Shanshan Ma, Shuting Zhu, Liucun Zhu, Wenna Guo

“…However, the heterogeneity of tumor immune response causes more than half of patients to not benefit from clinical immunotherapy and targeted therapy, which delays the patient’s condition and causes them to suffer adverse immune events’ side effects. …”
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The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review by Shafia Khairani, Nisa Fauziah, Hesti Lina Wiraswati, Ramdan Panigoro, Endang Yuni Setyowati, Afiat Berbudi

“…Curcumin is a potent antioxidant, damages parasite DNA, and may promote an immune response against Plasmodium by increasing reactive oxygen species (ROS), while piperine is also a potent antioxidant that potentiates the effects of curcumin. …”
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Live Plague Vaccine Development: Past, Present, and Future by Andrey P. Anisimov, Anastasia S. Vagaiskaya, Alexandra S. Trunyakova, Svetlana V. Dentovskaya

“…In this review, we present our opinion on reasonable tactics for the development and application of live, safe, and protective human plague vaccines causing an enhanced duration of protection and breadth of action against various virulent strains in vaccination studies representing different ages, genders, and nucleotide polymorphisms of the genes responsible for immune response.…”
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BK Polyomavirus and acute kidney injury in transplant recipients: signaling pathways and molecular mechanisms by Samar Bizhani, Afsoon Afshari, Ramin Yaghobi

“…Although reactivation is often asymptomatic, it can present as AKI, which is a risk factor for early loss of the transplanted organ. The immune response to BKPyV is crucial in controlling the virus and safeguarding organs from damage during infection. …”
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Alternanthera mosaic potexvirus: Several Features, Properties, and Application by Ekaterina Donchenko, Ekaterina Trifonova, Nikolai Nikitin, Joseph Atabekov, Olga Karpova

“…Furthermore, AltMV virions and VLPs demonstrate high immunogenicity, enhancing the immune response to the target antigen thus offering the possibility of being used as potential adjuvants. …”
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Porphyromonas gulae and canine periodontal disease: Current understanding and future directions by Kyu Hwan Kwack, Eun-Young Jang, Cheul Kim, Young-Suk Choi, Jae-Hyung Lee, Ji-Hoi Moon

“…Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. Further research is needed to understand strain-level diversity of virulence factors and interactions between P. gulae and other oral bacteria, particularly Fusobacterium nucleatum, a common pathogen in both dogs and humans. …”
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HDAC6 Facilitates PRV and VSV Infection by Inhibiting Type I Interferon Production by Hu Zheng, Xiaohui Yang, Haiwen Zhong, Changxu Song, Zhenfang Wu, Huaqiang Yang

“…This work demonstrates that HDAC6 affects the infection process of multiple viruses by modulating type I IFN production, highlighting a regulatory role of HDAC6 linking host immune response and viral infection levels in pig cells.…”
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Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts by Gayathri Vijayakumar, Anisha Latha, Aiswaria P. Anil, Yogini Surve, Aiswarya R, Bipin G. Nair, Indulekha CL. Pillai

“…Fibrosis is one of the major outcomes following injury in the heart. Immune response in the injury niche modulates fibrosis, yet little is known about how cell-autonomous immune signaling in adult cardiac fibroblasts regulates fibrosis. …”
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Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients by Joanna Bartosińska, Ewelina Zakrzewska, Dorota Raczkiewicz, Joanna Purkot, Anna Michalak-Stoma, Małgorzata Kowal, Dorota Krasowska, Grażyna Chodorowska, Krzysztof Giannopoulos

“…Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.…”
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Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency by Marcello Lanari, Silvia Vandini, Maria Grazia Capretti, Tiziana Lazzarotto, Giacomo Faldella

“…Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- and B-cell immune response unable to efficaciously neutralize viral replication, with subsequent increased viral shedding and potentially lethal lower respiratory tract infection. …”
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Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns by Gianluca Terrin, Annalisa Passariello, Francesco Manguso, Gennaro Salvia, Luciano Rapacciuolo, Francesco Messina, Francesco Raimondi, Roberto Berni Canani

“…To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight <1500 g and a postnatal age >72 hours of life. …”
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Intestinal permeability, food antigens and the microbiome: a multifaceted perspective by Francesco Valitutti, Francesco Valitutti, Maurizio Mennini, Gianluca Monacelli, Giulia Fagiolari, Marisa Piccirillo, Giovanni Di Nardo, Giuseppe Di Cara

“…Undoubtfully, each of these conditions is very different and quite unique, albeit food antigens/compounds, intestinal permeability and specific microbiota signatures orchestrate immune response and decide clinical outcomes for all of them.…”
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Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol by Jezrom B. Fordham, Afsar Raza Naqvi, Salvador Nares

“…One such disorder is periodontitis characterised by an antimicrobial immune response, inflammation, and irreversible changes to the supporting structures of the teeth. …”
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Serum CEACAM1 Correlates with Disease Progression and Survival in Malignant Melanoma Patients by Sapoznik Sivan, Faranesh Suzan, Ortenberg Rona, Hamburger Tamar, Barak Vivian, Peretz Tamar, Schachter Jacob, Markel Gal, Lotem Michal

“…DTH skin test is used to evaluate patients’ anti-melanoma immune response and to predict response to vaccination. …”
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Myocardial Regeneration via Progenitor Cell-Derived Exosomes by Janita A. Maring, Christien M. Beez, Volkmar Falk, Martina Seifert, Christof Stamm

“…The conceptual advantage is that they may be produced in industrial quantities and stored at the point-of-care for off-the-shelf application, ideally without eliciting a relevant recipient immune response or other adverse effects associated with viable cells. …”
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Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics by Olga V. Sergeeva, Liang Luo, Anthony Guiseppi-Elie, Anthony Guiseppi-Elie, Anthony Guiseppi-Elie

“…The principal approach of cancer vaccines is to induce a specific immune response against cancer cells. However, a major challenge in cancer immunotherapy is to predict which patients will respond to treatment and to monitor the efficacy of the vaccine during treatment. …”
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Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis by Elisabetta Volpe, Luca Battistini, Giovanna Borsellino

“…The identification of the features endowing Th17 cells with high pathogenicity in MS is of particular interest, and discoveries in Th17 cell biology and function could lead to the design of new strategies aimed at modulating the immune response in MS. Here, we will discuss recent advances in this field, with particular focus on the mechanisms conferring pathogenicity in MS and their potential modulation.…”
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Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae by Jamie E. Fegan, Epshita A. Islam, David M. Curran, Dixon Ng, Natalie Y. T. Au, Elissa G. Currie, Joseph J. Zeppa, Jessica Lam, Anthony B. Schryvers, Trevor F. Moraes, Scott D. Gray-Owen

“…However, it exhibits high levels of antigenic variability, posing a significant obstacle in evoking a broadly protective immune response. Here, we utilize phylogenetic information to rationally select TbpB variants for inclusion into a gonococcal vaccine and identify two TbpB variants that together elicit a highly cross-reactive antibody response against a diverse panel of TbpB variants and clinically relevant gonococcal strains. …”
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