Foot-and-mouth disease in Asia by Md. Abdur Rahman, Farah Zereen, Md. Liton Rana, Md. Golzar Hossain, Masaru Shimada, Sukumar Saha

“…This review discusses the prevalence of various FMD virus (FMDV) serotypes across Asia, along with the transmission modes, pathogenesis, immune response, and immune suppression by FMDV. Additionally, the review explores FMD diagnosis, prevention, and control strategies, and highlights future opportunities for research aimed at developing strain-specific viral and bacterial combined vaccines.…”
Get full text

How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by R. Gasparini, D. Panatto, N. L. Bragazzi, P. L. Lai, A. Bechini, M. Levi, P. Durando, D. Amicizia

“…Capsular polysaccharide and lipooligosaccharide glycan composition, in particular, play a major role in circumventing immune response. The understanding of these mechanisms has opened new horizons in the field of vaccinology. …”
Get full text

Trypanosoma cruzi SSP4 Amastigote Protein Induces Expression of Immunoregulatory and Immunosuppressive Molecules in Peripheral Blood Mononuclear Cells by Yadira Morán-Utrera, Aracely López-Monteon, José Luis Rosales-Encina, Enrique Méndez-Bolaina, Angel Ramos-Ligonio

“…Parasite molecules that regulate the host immune response during Chagas’ disease have not been fully identified, particularly proteins of the amastigote stage. …”
Get full text

Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance by Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Alejandra Gleisner, Daniela Sauma, Cinthia Silva, Juan Jose Saez, Sarah Nuñez, Mario Rosemblatt, Maria Rosa Bono

“…To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. …”
Get full text

Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses by Buyuan He, James T. Tran, David Jesse Sanchez

“…Overall, a better understanding of these mechanisms creates avenues to better understand the innate immune response to these viruses as well as plan the development of antivirals that would allow the natural antiviral effect of Type I Interferons to manifest during these infections.…”
Get full text

Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult by Yu-Jin Lee, D. Scott Smith, Vivek A. Rao, Robert D. Siegel, Jon Kosek, Carol A. Glaser, Alexander C. Flint

“…This case of fatal ANE in an adult is consistent with the hypothesis generated from pediatric cases that the host immune response, and not direct viral invasion of the CNS, is responsible for pathogenesis of ANE.…”
Get full text

Mannose-binding lectin gene sequence data in Kelantan population by Muhamad Aidil Zahidin, Noor Haslina Mohd Noor, Muhammad Farid Johan, Abu Dzarr Abdullah, Zefarina Zulkafli, Hisham Atan Edinur

“…Abstract The human mannose-binding lectin (MBL) gene encodes a polymorphic protein that plays a crucial role in the innate immune response. Human MBL deficiency is associated with immunodeficiencies, and its variants have been linked to autoimmune and infectious diseases. …”
Get full text

Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease by Seokjin Ham, Yeon-Mok Oh, Tae-Young Roh

“…Differentially expressed or co-expressed genes in the protein interaction subnetworks were linked with mitochondrial dysfunction and the immune response, as expected. Computational protein localization prediction revealed that 19 proteins showing changes in subcellular localization were mostly related to mitochondria, suggesting that mislocalization of mitochondria-targeting proteins plays an important role in COPD pathology. …”
Get full text

The Possible Correlation between the Patient's Immune Tolerance Level During Cesaerean Section and the Incidence of Subsequent Emergency Peripartum Hysterectomy by Lukasz Wicherek, Krystna Galazka

“…Conclusion. Abnormal immune response during labor may increase the risk for peripartum hysterectomy.…”
Get full text

Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers by I. V. Lyadova, A. V. Panteleev

“…CD4+ T cells play critical role during Mtb infection by mediating protection, contributing to inflammation, and regulating immune response. Th1 and Th17 cells are the main effector CD4+ T cells during TB. …”
Get full text

Posttranslational Modifications and the Immunogenicity of Biotherapeutics by Roy Jefferis

“…The individual is naturally tolerant to molecular forms of self-molecules but nonself variants can provoke an immune response with the generation of anti-drug antibodies (ADA); aggregated forms can exhibit enhanced immunogenicity and QC procedures are developed to avoid or remove them. …”
Get full text

Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment by Yifu Shu, Jing Li

“…Immune infiltration was assessed via ssGSEA, while transwell assays and immunofluorescence examined the effects of disulfidptosis-Tex genes on glioma cell behavior and immune response.ResultsEleven disulfidptosis-Tex genes were found critical for glioblastoma survival outcomes. …”
Get full text

Assessment of the Combined Effects of Heavy Metal Cobalt and Sublethal Radiation on the Immune System by Gulzhan Ilderbayeva, Aigul Utegenova, Oralbek Ilderbayev, Zhibek Sembaeva, Gulsum Askarova

“…Methods: The main immunosuppressive manifestation of the toxic dose of cobalt on the humoral component of the immune response is noted. Results: There is a decrease in the concentration of immunoglobulins (Igs) of the main classes in blood serum by 17%–30% (P < 0.05). …”
Get full text

Probiotic Bacteria Influence the Composition and Function of the Intestinal Microbiota by Paul W. O'Toole, Jakki C. Cooney

“…Mechanisms whereby probiotics impact on the intestinal microbiota include competition for substrates, direct antagonism by inhibitory substances, competitive exclusion, and potentially host-mediated effects such as improved barrier function and altered immune response. We now have the microbial inventories and genetic blueprints to begin tackling intestinal microbial ecology at an unprecedented level of detail, aided by the understanding that dietary components may be utilized differentially by individual phylotypes. …”
Get full text

The Role of Immune Defects and Colonization of Staphylococcus aureus in the Pathogenesis of Atopic Dermatitis by Danuta Nowicka, Ewelina Grywalska

“…Apart from increased adhesion of S. aureus in atopic skin, defects of the innate immune response resulting in the lack of restriction of the growth of microorganisms also contribute to susceptibility to colonization by and infection with S. aureus. …”
Get full text

Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report by Cristian Morán-Mariños, Felix Llanos-Tejada, Rebeca Huamani-Llantoy, Capriny Bernal-Turpo, Kimberly López-Pilco, Alex Ventura-Leon, Renato Casanova-Mendoza

“…Timely intervention with corticosteroids plays a key role in moderating the exaggerated immune response, helping to alleviate dermatological symptoms and prevent long-term organ damage. …”
Get full text

Immune Tolerance Regulation Is Critical to Immune Homeostasis by Lei Han, Tianxiang Wu, Qin Zhang, Anning Qi, Xiaohui Zhou

“…The body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. …”
Get full text

Evaluation of Task Shifting in Community-Based DOTS Program as an Effective Control Strategy for Tuberculosis by André P. Gabriel, Charles P. Mercado

“…Despite attempts to control and eradicate the mycobacterium, the prevalence of the disease remains high due to increasing population rate, persistence of poverty and poor health care, treatment failure, increasing multidrug resistance as a consequence of treatment failure and poor compliance, and existence of comorbid conditions that compromise immune response. Limited government resources to screen and monitor disease progression of TB in third world countries hamper the eradication of the disease. …”
Get full text

Unravelling the role of secretory Immnuoglobulin-A in COVID-19: a multicentre study in nursing homes during the first wave by Rafael Bielza, Patricia Pérez, Nuria García, Laura Ballesteros-Sanabria, Rosa María Martínez, Azam Ghazi, Clara Hernando, María Victoria Rodríguez, Israel J. Thuissard, Cristina Andreu-Vázquez, José Manuel Bautista

“…Abstract Background The function of mucosal secretory IgA (SIgA) seems to be paramount in the immune response against SARS-CoV-2 however, there are few studies addressing this issue specifically in the institutionalized older population. …”
Get full text

Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…This resulted in enrichment of the biological processes predominantly for complement activation alternative pathway, complement activation, complement activation classical pathway, humoral immune response, leukocyte mediated immunity, and negative regulation of endopeptidase activity in excellent-quality colostrum. …”
Get full text