TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART by HariOm Singh, Dharmesh Samani, Sumit Aggarwal

“…Toll-like receptors (TLRs) play an important role in the innate immune response to HIV infection. Single nucleotide polymorphism (SNP) in TLR7 (Gln11Leu) gene has been associated with a rapid decline of CD4T cell count. …”
Get full text

Pan-Cancer Analyses of the Tumor Microenvironment Reveal That Ubiquitin-Conjugating Enzyme E2C Might Be a Potential Immunotherapy Target by Guang-zhao Huang, Ze-qun Chen, Juan Wu, Ting-ru Shao, Chen Zou, Yi-long Ai, Xiao-zhi Lv

“…In addition, both immune relevance analysis and GSEA showed that UBE2C might participate in immune response in many cancers. Furthermore, the UBE2C mRNA level and protein level were all identified as upregulated in OSCC cell lines and tissues. …”
Get full text

Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling Pathways by Linjie Fang, Tingyu Tang, Mengqi Hu

“…Then, based on GSEA, the enrichment of the gene set in the sample was analyzed in the GO terms, and the gene set was enriched in the positive regulation of myeloid leukocyte cytokine production involved in immune response, programmed necrotic cell death, translesion synthesis, necroptotic process, and condensed nuclear chromosome. …”
Get full text

Generation of IgM+ B cell-deficient Atlantic salmon (Salmo salar) by CRISPR/Cas9-mediated IgM knockout by Mari Raudstein, Ma. Michelle D. Peñaranda, Erik Kjærner-Semb, Søren Grove, H. Craig Morton, Rolf Brudvik Edvardsen

“…Immunoglobulin M (IgM) is the main antibody involved in the systemic immune response of teleosts, including Atlantic salmon. …”
Get full text

Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia by Amal Dafar, Angelica Siarov, Yasaman Mostaghimi, Jairo Robledo-Sierra, Shahin De Lara, Daniel Giglio, Göran Kjeller, Paulo Henrique Braz-Silva, Jenny Öhman, Bengt Hasséus

“…No differences were found in the expression of Ki-67 and the number of CD1a+ cells between the two groups. Although an immune response is elicited in both conditions, there are differences at the cellular level between OLP and LPL. …”
Get full text

Clinical and Morphological Manifestations of Gastritis and Serum Cytokine Levels in Schoolchildren with Familial History of Gastric Cancer by T. V. Polivanova, E. V. Kasparov, V. A. Vshivkov

“…In positive history and negative H. pylori tests, the cell immune response regulator IL-18 37 was revealed elevated in histology. …”
Get full text

Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India by Ranjan S. Rana, Bitan Naik, Mahima Yadav, Usha Singh, Anup Singh, Shailja Singh

“…HLA class II alleles are critical to immune response and are highly polymorphic. Various alleles in HLA-DR and -DQ regions were analyzed in SLE patients and healthy controls to see their role in susceptibility or protection to SLE. …”
Get full text

Chia (<i>Salvia hispanica</i>) Seed Oil Modulates the Haemato-Immunological Response, Antioxidative Status and Cytokine Gene Expression of Tropical Freshwater Teleost, <i>Labeo roh... by Sanjay Kumar Gupta, Rajan Gupta, Akruti Gupta, Md Javed Foysal, Kishore Kumar Krishnani

“…The present investigation attempts to evaluate the impact of the dietary inclusion of chia (<i>Salvia hispanica</i>) seed oil (CSO) on the indices of haemato-immunology, metabolic enzymes, and expression of immune-responsive cytokine genes in <i>Labeo rohita</i> (rohu) fingerlings. …”
Get full text

Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform by Pengyu Gao, Dan Zou, Ansha Zhao, Ping Yang

“…These cells possess extended circulation times and innate chemomigration ability and can activate an immune response that exerts therapeutic effects. However, new challenges have emerged, such as payloads, cell function change, cargo leakage, and in situ release. …”
Get full text

Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality by Noura Al-Dayan, Divya Venugopal, Sugapriya Dhanasekaran

“…The genetic architecture of the immune response genes in the Indian population, BCG vaccination, the predominantly young age group of people, and their traditional food habits might contribute to the lower rate of mortality. …”
Get full text

Problems with studying directional natural selection in humans by S. V. Mikhailova

“…., for those associated with an immune response and cognitive abilities. Examination of the correlation between fertility and educational attainment yields conflicting results. …”
Get full text

In-silico formulation of a next-generation polyvalent vaccine against multiple strains of monkeypox virus and other related poxviruses. by Abu Tayab Moin, Nurul Amin Rani, Rajesh B Patil, Tanjin Barketullah Robin, Md Asad Ullah, Zahidur Rahim, Md Foyzur Rahman, Talha Zubair, Mohabbat Hossain, A K M Moniruzzaman Mollah, Nurul Absar, Mahboob Hossain, Mohammed Abul Manchur, Nazneen Naher Islam

“…Both constructs were found to be highly antigenic, non-allergenic, nontoxic, and soluble, suggesting their potential to generate an adequate immune response and be safe for humans. Vaccine construct 1 was selected for molecular dynamic simulation studies. …”
Get full text

Machine learning-assisted cancer diagnosis in patients with paraneoplastic autoantibodies by Alireza Maleki, Mohammad Mahdi Mirza Ali Mohammadi, Shahab Gholizadeh, Behnaz Dalvandi, Mohammad Rahimi, Aidin Tarokhian

“…Abstract Purpose Paraneoplastic syndromes (PNS) are a group of rare disorders triggered by an immune response to malignancy, characterized by diverse neurological, muscular, and systemic symptoms. …”
Get full text

Identification of Hypoxia Signature to Assess the Tumor Immune Microenvironment and Predict Prognosis in Patients with Ovarian Cancer by Chunyan Wei, Xiaoqing Liu, Qin Wang, Qipei Li, Min Xie

“…The hypoxia risk model could serve as an independent prognostic indicator and reflect overall immune response intensity in the OC microenvironment.…”
Get full text

Comparative effectiveness of liquid and freeze-dried vaccines for oral vaccination of dogs against rabies by Z. D. Yershebulov, A. T. Zhunushov, Zh. T. Amanova

“…The level of the immune response against rabies in the vaccinated dogs was assessed by intracerebral infection of animals with virulent rabies virus strain CVS. …”
Get full text

In Silico Design of a Trans-Amplifying RNA-Based Vaccine against SARS-CoV-2 Structural Proteins by Fatemeh Nafian, Ghazal Soleymani, Zahra Pourmanouchehri, Mahnaz Kiyanjam, Simin Nafian, Sayed Mohammad Mohammadi, Hanie Jeyroudi, Sharareh Berenji Jalaei, Fatemeh Sabzpoushan

“…It consists of two molecules: a nonreplicating RNA encoding a trans-acting replicase to amplify the second one, a trans-replicon (TR) RNA encoding the vaccine protein. Overall, the immune response simulation detected that activated B and T lymphocytes and increased memory cell formation. …”
Get full text

The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis by Jiao Gong, Yaqiong Chen, Jing Cao, Yang Wang, Jiahao Chen, Danyang Li, Liuping Sha, Xinhua Li, Yutian Chong, Bo Hu

“…PPI network and gene cluster analysis of immune genes and apoptosis and necroptosis genes suggested that hub genes were mainly related to immune response and apoptosis. In summary, our study offers a conceptual framework to understand the immune landscape of HBV-ALF, which might help to improve prognosis.…”
Get full text

Adjuvant properties of chitosan derivatives administered to mice with anti-rabies vaccine by K. B. Dobroskok, E. I. Yarygina, M. S. Lipatova, M. S. Kalmykova

“…Much information is available now on chitosan positive effect, including its effect on the immune response. The article provides results of the preclinical tests for different affordable chitosan-based products. …”
Get full text

Outer Membrane Vesicles Derived from Adherent-Invasive Escherichia coli Induce Inflammatory Response and Alter the Gene Expression of Junction-Associated Proteins in Human Intestin... by Bahareh Nadalian, Banafsheh Nadalian, Mohammad Reza Zali, Abbas Yadegar

“…The aim of this study was to determine the ability of OMVs derived from AIEC strain LF82 to induce the host immune response, leading to production of proinflammatory cytokines and also altering the gene expression of junction-associated proteins in the human epithelial colorectal adenocarcinoma Caco-2 cell line. …”
Get full text

Mesenchymal Stem Cells from Human Exfoliated Deciduous Teeth and the Orbicularis Oris Muscle: How Do They Behave When Exposed to a Proinflammatory Stimulus? by Alessander Leyendecker Junior, Carla Cristina Gomes Pinheiro, Daniela Yukie Sakai Tanikawa, José Ricardo Muniz Ferreira, Mariane Tami Amano, Daniela Franco Bueno

“…Mesenchymal stem cells (MSCs) have been studied as a promising type of stem cell for use in cell therapies because of their ability to regulate the immune response. Although they are classically isolated from the bone marrow, many studies have sought to isolate MSCs from noninvasive sources. …”
Get full text