Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases by Donatella Comito, Claudio Romano

“…The fundamentals of IBD pathogenesis are considered a defective innate immunity and bacterial killing with overaggressive adaptive immune response. A condition of “dysbiosis”, with alterations of the gut microbial composition, is regarded as the basis of IBD pathogenesis. …”
Get full text

NKT Cells in Sepsis by Briana Leung, Hobart W. Harris

“…Here, we will review the role of NKT cells in sepsis and septic shock, the immunoregulatory role of apoE in the host immune response to infection, and propose a mechanism for this immunoregulation.…”
Get full text

Leprosy: An Overview of Pathophysiology by Ramesh Marne Bhat, Chaitra Prakash

“…The susceptibility to the mycobacteria and the clinical course of the disease are attributed to the host immune response, which heralds the review of immunopathology of this complex disease.…”
Get full text

Sixth nerve palsy post covid treated with course of oral steroids by Divya Upendra Caculo, Sowmya Raveendra Murthy, Ann Willy, N Nishant

“…Research suggests that SARS- COV 2 infection can result in inflammatory nerve damage due to aberrant immune response leading to neuropathy. We report a case of a 42-year-old man presenting with a unilateral abducens nerve palsy following Covid-19 infection treated with a course of steroids leading to faster recovery.…”
Get full text

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders by Keren Zhou, Ligen Shi, Yan Wang, Sheng Chen, Jianmin Zhang

“…These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. …”
Get full text

Extreme Rhabdomyolysis, Acute Renal Failure, and Protracted Ileus in a Case of Legionella Pneumonia by C. Laivier, M.-O. Bleuze, P. Hantson, J. Devos

“…This case illustrates the apparent discrepancy between the pulmonary symptoms and the extrapulmonary manifestations that could be seen as a consequence of an exaggerated immune response.…”
Get full text

THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION by O. E. Redina, L. O. Klimov, N. I. Ershov, T. O. Abramova, L. N. Ivanova, L. A. Markel

“…The functional annotation of the genes significantly expressed in renal medulla of just one of the compared rat strains revealed the genes involved in immune response regulation.…”
Get full text

Dengue infection changes the expressions of CD154 and CD148 in human platelets by Sayali Vedpathak, Sonali Palkar, AkhileshChandra Mishra, Vidya A Arankalle, Shubham Shrivastava

“…Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. …”
Get full text

Toll-Like Receptors in Leishmania Infections: Guardians or Promoters? by Marilia S. Faria, Flavia C. G. Reis, Ana Paula C. A. Lima

“…The outcome of infection depends on the quality of the adaptive immune response, which is determined by parasite factors and the host genetic background. …”
Get full text

Dyarrheal Syndrome in a Patient Co-Infected with Leishmania infantum and Schistosoma mansoni by Gláucia Fernandes Cota, Luciana Inácia Gomes, Bruna Fernandes Pinto, Joanna R. Santos-Oliveira, Alda Maria Da-Cruz, Moisés Salgado Pedrosa, Wagner Luiz Tafuri, Ana Rabello

“…This case stresses the importance of atypical symptoms and the unusual location of visceral leishmaniasis, not only in immunodepressed patients, and raises the possible influence of chronic infection by S. mansoni reducing the immune response to Leishmania.…”
Get full text

Alcoholism and Inflammatory Response: Implications for Liver and Cardiovascular Disease by Christian Gabriel Acosta Ricachi, Sheila Ivette Quinapanta Serrano, Álvaro Paúl Moina Veloz

“…Among the main mechanisms that cause these injuries are: alterations in the immune response, increased oxidative stress and methylation alterations. …”
Get full text

Hemizygous Moesin (MSN) Gene Deletion in an Adult With Chronic Neutropenia by Yandy Marx Castillo-Aleman, Francisco Sotomayor-Lugo, Sherjeel Sana, Nameer Abdul Raheem Kadhum Al-Saadawi, Yendry Ventura-Carmenate, David Dennison, Gianina Statache, Julieta Osorio-Zuluaga, Ahmad Raza, David Grossman

“…It is characterized by cytopenias, hypogammaglobulinemia, poor immune response to vaccine antigens, and increased susceptibility to early-life infections. …”
Get full text

Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages by Haruaki Tomioka, Yutaka Tatano, Win Win Maw, Chiaki Sano, Yuichi Kanehiro, Toshiaki Shimizu

“…In the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. …”
Get full text

The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent by Jessica M. S. Jutzy, Jeffrey M. Lemons, Jason J. Luke, Steven J. Chmura

“…Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease. …”
Get full text

Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review by Deborah Majchel, Mary T. Korytkowski

“…CTLA-4 agents are associated with immune-related adverse effects (irAE) which occur as a result of activation (or lack of inactivation) of the immune response. This impacts not only malignant cells but also different host organ-systems. …”
Get full text

Rhinovirus-Induced Exacerbations of Asthma and COPD by Marc B. Hershenson

“…While the innate immune response likely plays a role in rhinovirus-induced exacerbations, its precise role, either adaptive or maladaptive, is debated. …”
Get full text

Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy by Saber Imani, Xiaoyan Li, Keyi Chen, Mazaher Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Mehrdad Hashemi, Saloomeh Khoushab, Saloomeh Khoushab, Xiaoping Li

“…Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have significantly enhanced the design, prediction, and optimization of mRNA vaccines. …”
Get full text

Optimal Treatment Strategies for HIV with Antibody Response by Yinggao Zhou, Kuan Yang, Kai Zhou, Chunling Wang

“…An HIV model of ordinary differential equation, which includes immune response, neutralizing antibodies, and multidrug effects, is improved. …”
Get full text

Analysis of a cancer dormancy model and control of immuno-therapy by Ben Sheller, Domenico D'Alessandro

“…We identify an equilibrium point corresponding to a survivable amount of cancer cells which are exactly balanced by the immune response. This situation corresponds to cancer dormancy. …”
Get full text

Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial by Simon Valayer, Marie Alexandre, Mélanie Prague, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Brian Greenwood, Bailah Leigh, Marie Poupelin, Christine Schwimmer, Samba O. Sow, Irina Maljkovic Berry, Jens H. Kuhn, Daniela Fusco, Natasha Dubois Cauwelaert, Deborah Watson-Jones, Rodolphe Thiébaut, Yves Lévy, Yazdan Yazdanpanah, Laura Richert, Edouard Lhomme

“…In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols.Trial registration: ClinicalTrials.gov identifier: NCT02876328.…”
Get full text