Actinomycotic osteonecrosis of the maxilla as a post-covid sequelae: A case report by V Vasanthi, Selvakumar Thulasiraman, Rajkumar Krishnan, Annasamy Ramesh Kumar

“…The dysregulated immune response from COVID-19 infection predisposes patients to opportunistic infections. …”
Get full text

The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections by Mohlopheni Jackson Marakalala, Lisa M. Graham, Gordon D. Brown

“…These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) and which can influence the host immune response to the infection. Although many of the PRRs appear to be redundant in the control of M. tuberculosis infection in vivo, recent discoveries have revealed a key, nonredundant, role of the Syk/CARD9 signalling pathway in antimycobacterial immunity. …”
Get full text

Fractalkine and Other Chemokines in Primary Biliary Cirrhosis by Shinji Shimoda, Carlo Selmi, M. Eric Gershwin

“…We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC.…”
Get full text

Should Genetics Be Blamed for High Incidence of Uterine Disease in Dairy Cows? by Klibs N. Galvão, Christopher M. Seabury, Pablo Pinedo

“…This 3-page fact sheet presents the results of a recent paper that examined how alterations on the TLR genes, which control innate immune response, affect the susceptibility to uterine diseases. …”
Get full text

Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target by Han Gao, Songmin Ying, Yuanrong Dai

“…It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. …”
Get full text

Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…Our data suggest an evolution of VOC in modulating the host immune response, with a strong change in pace beginning with the advent of the Delta variant. …”
Get full text

Unraveling the transcriptomic effects of leucine supplementation on muscle growth and performance in basketball athletes. by Sinan Wang, Weishuai Guo, Rui Dong

“…Identified DEGs enriched in pathways related to immune response, cytokine production, and cell adhesion. …”
Get full text

Effects of Enterocytozoon hepatopenaei infection on intestinal immune defense and physiological processes of Penaeus vannamei by Zheng Cao, Chuanyu He, Zhipeng Yin, Caiyi Chen, Fan Li, Dongchun Yan, Ting Li, Linrui Chang, Lingjun Si

“…Concurrently, EHP infection can trigger intestinal immune response, and the expression of key immune genes like Toll, myeloid differentiation factor, anti-lipopolysaccharide factor, and Relish was significantly enhanced, while the expression of IMD and alkaline phosphatase was suppressed. …”
Get full text

Antibody and serum bactericidal response to Burkholderia pseudomallei in acute localized and septicemic melioidosis cases with diabetes mellitus by Sraboni Mazumder, Md. Shariful Alam Jilani, Lovely Barai, KM Shahidul Islam

“…Background and objectives: Melioidosis, caused by the gram-negative bacillus Burkholderia pseudomallei, is a major cause of fatal community acquired infection in diabetic patients. Protective immune response in human melioidosis is not clearly understood yet. …”
Get full text

Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure by Ikeotunye Royal Chinyere, Pierce Bradley, Joshua Uhlorn, Joshua Eason, Saffie Mohran, Giuliana G. Repetti, Sherry Daugherty, Jen Watson Koevary, Steven Goldman, Jordan J. Lancaster

“…However, the durability of effect, immune response, and in vitro properties of the tissue graft remained uncharacterized. …”
Get full text

Reduced irradiation exposure areas enhanced anti-tumor effect by inducing DNA damage and preserving lymphocytes by Huiqin Chen, Yuan Li, Qiaofeng Shen, Guanqun Guo, Zhigang Wang, Hanyu Pan, Min Wu, Xueqing Yan, Gen Yang

“…Abstract Background Partial stereotactic body radiation therapy (SBRT) targeting hypoxic regions of large tumors (SBRT-PATHY) has been shown to enhance the efficacy of tumor radiotherapy by harnessing the radiation-induced immune response. This approach suggests that reducing the irradiation target volume not only achieves effective anti-tumor effects but also minimizes damage to surrounding normal tissues. …”
Get full text

A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Down-regulated genes (FCERIA, IL7R, CCR7, CX3CR1, CD3G, CD40LG, CD247, CD3E, and GZMK) were associated with adaptive immune response, T cell function, and antigen processing and presentation. …”
Get full text

Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model by Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson, Jan Sjölin, Paul Skorup, Anders Wall, Viola Wilson, Markus Castegren, Gunnar Antoni

“…Neutrophil activation is part of the dysregulated immune response to infection defining sepsis and neutrophil elastase is one of the powerful proteases causing both effects and damage. …”
Get full text

Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80+ liver-associated macrophages by Chitsuda Pongma, Pornlapat Keawvilai, Atsadang Boonmee, Benjawan Wongprom, Thitiporn Pattarakankul, Chutamath Sittplangkoon, Mohamad-Gabriel Alameh, Patipark Kueanjinda, James Heyes, Kieu Lam, Benjawan Saechue, Kiat Ruxrungtham, Tanapat Palaga

“…Abstract Delivery of an mRNA formulated with lipid nanoparticles (LNPs) induces robust humoral and cell-mediated branches of the immune response. Depending on the LNP formula, mRNA encoding proteins can be detected in the liver upon intramuscular administration of mRNA/LNP in mice. …”
Get full text

The role of TNF-α inhibitor in glioma virotherapy: A mathematical model by Elzbieta Ratajczyk, Urszula Ledzewicz, Maciej Leszczynski, Avner Friedman

“…Virotherapy, using herpes simplex virus, represents a promising therapy of glioma. But the innate immune response, which includes TNF-α produced by macrophages, reduces the effectiveness of the treatment. …”
Get full text

Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease by G. V. Paramel, A. Sirsjö, K. Fransén

“…Studies have reported that these exogenous and endogenous components may perturb the balance of innate immune response by activating the NLRP3 inflammasome. …”
Get full text

Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms by Jiali Yao, Linlin Ji, Guang Wang, Jin Ding

“…Abstract Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. …”
Get full text

Relapse of Visceral Leishmaniasis in an HIV-Infected Patient Successfully Treated with a Combination of Miltefosine and Amphotericin B by Shauna McQuarrie, Ken Kasper, Dana C Moffatt, Daniel Marko, Yoav Keynan

“…The present report documents a 49-year-old HIV-infected man receiving antiretroviral therapy with a suboptimal immune response and a CD4 count of 95 cells/mm3, despite virological suppression. …”
Get full text

The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases by Lin Li, Panyang Xu, Qi Zhou, Jiancheng Xu

“…TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. …”
Get full text

Dynamic Multidrug Therapies for HIV: Optimal and STI Control Approaches by B. M. Adams, H. T. Banks, Hee-Dae Kwon, Hien T. Tran

“…Ournumerical results support a scenario in which STI therapies canlead to long-term control of HIV by the immune response systemafter discontinuation of therapy.…”
Get full text