Vaccines and Immunotherapeutics for the Treatment of Malignant Disease by Joel F. Aldrich, Devin B. Lowe, Michael H. Shearer, Richard E. Winn, Cynthia A. Jumper, Ronald C. Kennedy

“…The specificity of the immune response and potential for establishing long-term tumor immunity compels researchers to continue investigations into immunotherapeutic approaches for cancer. …”
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The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes by Monika Ryba-Stanisławowska, Maria Skrzypkowska, Jolanta Myśliwska, Małgorzata Myśliwiec

“…IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. …”
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Preface by Peter Hinow, Pierre Magal, Shigui Ruan

“…Webb.The topics of the 12 articles appearing in this special issue includeevolutionary dynamics of population growth, spatio-temporal dynamicsin reaction-diffusion biological models, transmission dynamics ofinfectious diseases, modeling of antibiotic-resistant bacteria in hospitals,analysis of Prion models, age-structured models in ecology and epidemiology,modeling of immune response to infections, modeling of cancer growth, etc.These topics partially represent the broad areas of Glenn's research interest.For more information please click the “Full Text” above.…”
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Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease by Francisca Cornejo, Rommy von Bernhardi

“…Here, we review the participation of the immune response mediated by glial cells in Alzheimer’s disease and the role played by scavenger receptors in the development of this pathology, focusing on the relevance of class A scavenger receptor (SR-A) for Aβ clearance and inflammatory activation of glial cell, and as a potential target for Alzheimer’s disease therapy.…”
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Immunomodulatory effects of mononuclear 5,6-epoxy-5,6-dihydro-1,10-phenanthroline platinum(II) complex by Stanisavljević Isidora, Živković Marija, Rajković Snežana, Obradović Milica, Jurišević Milena, Pavlović Slađana, Simović-Marković Bojana, Gajović Nevena, Ćorović Irfan, Jocić Miodrag, Kostić Andrija, Jovanović Ivan

“…In this study, the effects of this platinum(II) complex on the immune response were assessed. Peritoneal macrophages and splenocytes obtained from mice were treated with lipopolysaccharide (LPS)/Concanavalin A (ConA) along with platinum(II) complex and measurement of cytokine concentrations and immunophenotyping was performed. …”
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HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy by Vera Rebmann, Fabiola da Silva Nardi, Bettina Wagner, Peter A. Horn

“…Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.…”
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Cytokine gene regulation by PGE2, LTB4 and PAF by M. Rola-Pleszczynski, J. Stankova

“…The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. …”
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Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development by Micaella Kantor, Anarella Abrantes, Andrea Estevez, Alan Schiller, Jose Torrent, Jose Gascon, Robert Hernandez, Christopher Ochner

“…As more is learned about its pathogenesis and the host’s immune response, the potential for developing a vaccine holds promise. …”
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Age influences the circulating immune profile in pediatric sepsis by Grace Fisler, Grace Fisler, Grace Fisler, Mariana R. Brewer, Mariana R. Brewer, Mariana R. Brewer, Omar Yaipen, Clifford S. Deutschman, Clifford S. Deutschman, Clifford S. Deutschman, Matthew D. Taylor, Matthew D. Taylor, Matthew D. Taylor

“…BackgroundThe immune response changes as patients age, yet studies on the immune dysregulation of sepsis often do not consider age as a key variable.ObjectiveWe hypothesized that age would influence the immune response in septic children and that there would be a distinct variation in the immune profile in healthy children and children with either sepsis, uncomplicated infection, or acute organ dysfunction without infection. …”
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Measles and Pregnancy: Immunity and Immunization—What Can Be Learned from Observing Complications during an Epidemic Year by Rosalia Ragusa, Armando Platania, Mario Cuccia, Gaetano Zappalà, Gabriele Giorgianni, Placido D’Agati, Maria Alessandra Bellia, Marina Marranzano

“…As measles causes a dysregulation of the entire immune system, we describe immunological variations and how immune response mechanisms can lead to adverse pregnancy outcomes. …”
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Quaternary ammoniums activate human dendritic cells and induce a specific T-cell response in vitro by Marine Peyneau, Mathilde Zeller, Virginie Paulet, Benoît Noël, Marie-Hélène Damiens, Natacha Szely, Andreas Natsch, Marc Pallardy, Sylvie Chollet-Martin, Luc de Chaisemartin, Saadia Kerdine-Römer

“…Conclusions: We provide evidence at the cellular level that some QACs can elicit an immune response, which could be in line with the hypothesis of these molecules' role in NMBA sensitization.…”
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Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris by Rodolfo Pessato Timoteo, Marcos Vinicius da Silva, Camila Botelho Miguel, Djalma Alexandre Alves Silva, Jonatas Da Silva Catarino, Virmondes Rodrigues Junior, Helioswilton Sales-Campos, Carlo Jose Freire Oliveira

“…Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. …”
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Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

“…Activation of innate immunity is already detectable in the peripheral blood of individuals with pre-malignant advanced adenomas. This immune response is followed by signs of transient B-cell activation and sustained inhibition of T-cell responses along CRC progression, whereby at late stages, protumoral myeloid cells, wound healing and coagulation processes prevail. …”
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After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia by Mario Delia, Paola Carluccio, Anna Mestice, Roberta Frappampina, Francesco Albano, Giorgina Specchia, Pellegrino Musto

“…In particular, immune suppressive regulatory T cells (Tregs) may contribute to this defective antileukemic immune response, being recruited by bone marrow leukemic cells to evade immune surveillance. …”
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Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions by Zygmunt Mackiewicz, Justyna Mażul, Ieva Narkevičiūtė, Irena Dumalakienė, Irena Butrimienė, Rita Vilienė, Indrė Stankevičienė, Diana Mieliauskaitė

“…Immunohistochemical analysis of immune response to the suggested silent persistence of mumps virus in the minor labial salivary gland biopsies and flow cytometric analysis of blood cells was done. …”
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Investigating the inflammatory effect of microplastics in cigarette butts on peripheral blood mononuclear cells by Monire Soltani, Abbas Shahsavani, Philip K. Hopke, Nadali Alavi Bakhtiarvand, Mehrnoosh Abtahi, Masoumeh Rahmatinia, Majid Kermani

“…Peripheral blood mononuclear cells showed an inflammatory immune response when exposed to 200 µg/ml cellulose acetate from cigarette filters. …”
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Macrophage Extracellular Traps: Current Opinions and the State of Research regarding Various Diseases by Weizhen Weng, Zuoyu Hu, Yunfeng Pan

“…Macrophages are an important component of the human immune system and play a key role in the immune response, which can protect the body against infection and regulate the development of tissue inflammation. …”
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Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors by Hao Zhang, Zhiyi He, Wenting Zeng, Hong-Juan Peng

“…This review describes the epidemiological characteristics of pregnancy with dengue and the initial immune response to dengue infection, especially in IFNs production in this group of patients. …”
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Viruses Seen by Our Cells: The Role of Viral RNA Sensors by Elias A. Said, Nicolas Tremblay, Mohammed S. Al-Balushi, Ali A. Al-Jabri, Daniel Lamarre

“…The role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. …”
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Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug by Cristiana Perrotta, Paolo Pellegrino, Eliana Moroni, Clara De Palma, Davide Cervia, Piergiorgio Danelli, Emilio Clementi

“…Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn’s disease are the commonest forms. …”
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