Effects of cold-pressed wheat germ oil and Bacillus subtilis on growth performance, digestibility, immune status, intestinal microbial enumeration, and gene expression of broilers... by Abdel-Moneim Eid Abdel-Moneim, Safaa A.M. Ali, M.G. Sallam, Ahmed M. Elbaz, Noura M. Mesalam, Zangabel S. Mohamed, AbdelRahman Y Abdelhady, Bing Yang, Mohamed Farouk Elsadek

“…This study evaluated the effect of wheat germ oil (WGO), Bacillus subtilis, and their combination on growth performance, immune response, nutrient digestibility, intestinal microbial, oxidative status, and gene expression in heat-stressed broilers. …”
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Immunological mechanisms of tuberculosis susceptibility in TB-infected individuals with type 2 diabetes mellitus: insights from mycobacterial growth inhibition assay and cytokine a... by Bindu Dasan, Anuradha Rajamanickam, Arul Nancy Pandiarajan, Sivakumar Shanmugam, Sujatha Nott, Subash Babu

“…The observed cytokine profile in TBI-T2DM individuals indicates a compromised immune response against M.tb activation, potentially explaining the heightened risk of active TB in this population.IMPORTANCEThis study is important because it sheds light on the impaired immune response in individuals with type 2 diabetes mellitus (T2DM) who are infected with Mycobacterium tuberculosis (M.tb), offering critical insights into why they are at higher risk of developing active tuberculosis (TB). …”
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Inflammatory bowel disease induced by bimekizumab by Dominika Wietrzykowska-Grishanovich, Maciej Pleskacz, Radosław Kempiński

“…The development of knowledge about molecular processes and the aetiology of diseases are made possible the implementation of modern therapies with biological drugs, which are a heterogeneous group of substances working by modulating the body’s immune response. Currently, biological medications are used in an increasing number of indications.…”
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Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia by Todia P. Setiabudiawan, Lika Apriani, Ayesha J. Verrall, Fitria Utami, Marion Schneider, Agnes R. Indrati, Pauline P. Halim, Paulina Kaplonek, Hadar Malca, Jessica Shih-Lu Lee, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Mihai G. Netea, Bachti Alisjahbana, Ryan P. McNamara, Galit Alter, Arjan van Laarhoven, James E. Ussher, Katrina Sharples, Valerie A. C. M. Koeken, Philip C. Hill, Reinout van Crevel

“…This could be explained by an IFN-γ-independent adaptive immune response, or an effective innate host response clearing Mycobacterium tuberculosis (Mtb) without adaptive immunity. …”
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Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia by Toni Spence, Philip J. Allsopp, Alison J. Yeates, Maria S. Mulhern, J. J. Strain, Emeir M. McSorley

“…The maternal immune response is essential for successful pregnancy, promoting immune tolerance to the fetus while maintaining innate and adaptive immunity. …”
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NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma by Jiaxin Yin, Yuxiao Song, Yang Fu, Jun Wang, Zhimin Zhang, Shasha Ruan, Gaoli Liu, Bicheng Zhang

“…Abstract The anti-tumor immune response is greatly hindered by the protumor polarization of tumor-associated macrophages (TAMs). …”
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Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis by Rongjiong Zheng, Songsong Xie, Qiong Zhang, Ling Cao, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang

“…Brucella is an intracellular infection bacterium; the pathogenesis of Brucella and chronicity of infection may be related to the immune response of T cells. T lymphocytes mainly participate in cellular immune response. …”
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Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention by Qiqi Zhang, Dandan Yang, Xingxing Han, Yu Ren, Yongqi Fan, Chao Zhang, Lei Sun, Tingting Ye, Qiushuang Wang, Youhao Ban, Yunxia Cao, Huijuan Zou, Zhiguo Zhang

“…These molecules regulate the immune response by interacting with pattern recognition receptors (PRRs) and play important roles in inflammatory response, tissue repair, infection defense, and cancer treatment. …”
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OMP38 of Carbapenem‐Resistant Acinetobacter Baumannii‐Mediated mtDNA Release Activates the cGAS‐STING Signaling to Induce Inflammatory Response by Yang Yang, Yuanyuan Zeng, Jianjie Zhu, Jianjun Li, Lei Gu, Lin Wei, Zeyi Liu, Jian‐an Huang

“…However, the role of the innate immune response in CRAB infection is poorly understood. …”
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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections by Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin

“…However, the role of TLS in immune response and the molecules that drive its formation remain uncertain. …”
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Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients by Lucile Dumolard, Marie-Noelle Hilleret, Marie-Noelle Hilleret, Charlotte Costentin, Charlotte Costentin, Marion Mercey-Ressejac, Marion Mercey-Ressejac, Nathalie Sturm, Nathalie Sturm, Theophile Gerster, Thomas Decaens, Thomas Decaens, Evelyne Jouvin-Marche, Patrice N. Marche, Zuzana Macek Jilkova, Zuzana Macek Jilkova

“…BackgroundPatients with chronic hepatitis B virus (HBV) infection are characterized by impaired immune response that fails to eliminate HBV. Immune checkpoint molecules (ICMs) control the amplitude of the activation and function of immune cells, which makes them the key regulators of immune response.MethodsWe performed a multiparametric flow cytometry analysis of ICMs and determined their expression on intrahepatic lymphocyte subsets in untreated and treated patients with HBV in comparison with non-pathological liver tissue.ResultsThe liver of untreated HBV patients exhibited a high accumulation of PD-1+CD8+ T cells, while the frequencies of 4-1BB+ T cells, 4-1BB+ natural killer (NK) cells, and TIM-3+CD8+ T cells were the highest in the chronic hepatitis phase. …”
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YTHDF1-mediated m6A modification of GBP4 promotes M1 macrophage polarization in acute lung injury by Fengan Cao, Shilei Wang, Qiuyue Tan, Junna Hou, Yunlu Li, Wentao Ma, Shilong Zhao, Jing Gao

“…This research investigates the influence of m6A (N6-methyladenosine) modification on GBP4, a protein pivotal for macrophage polarization, a critical immune response in ALI. Methods Utilizing a mouse model to induce ALI, the study analyzed GBP4 expression in alveolar macrophages. …”
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Serum Levels of LL-37 and Inflammatory Cytokines in Plaque and Guttate Psoriasis by Young Ji Hwang, Ho Jung Jung, Min Jung Kim, Nam Kyung Roh, Jae Wook Jung, Yang Won Lee, Yong Beom Choe, Kyu Joong Ahn

“…It is assumed that the plaque phenotype of psoriasis is associated with T helper (Th) 1 immune response activation, while the guttate phenotype is associated with the Th17 immune response. …”
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Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection by Chen Zou, Minjie Zhao, Jingjing Yu, Dandan Zhu, Yunzhi Wang, Xinping She, Yanan Hu, Zhi Zheng

“…The most notable GO annotations in level 3 and REACTOME pathways describing the differentially expressed proteins were “innate immune response” and “platelet degranulation.” The intravitreal levels of APOA2 and CP were lower in the IVC group than in the PDR group (p<0.01). …”
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Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection by Robson Da Paixão De Souza, Luciana Santos Cardoso, Giuseppe Tittoni Varela Lopes, Maria Cecília F. Almeida, Ricardo Riccio Oliveira, Leda Maria Alcântara, Edgar M. Carvalho, Maria Ilma Araujo

“…Periportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens. We evaluated the immune response in S. mansoni infected individuals with different degrees of periportal fibrosis. …”
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Systematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carc... by Yan-ping Zou, Xiao-feng Shan, Jia-xuan Qiu, Yan Geng, Shang Xie, Ruo-lan Xiang, Zhi-gang Cai

“…High EMT scores correlated with upregulated EMT and immune response activity, indicating poor prognosis. Single-sample gene set enrichment analysis unveiled the tumors’ immune infiltration signature, suggesting active antigen presentation and a positive immune response for immunotherapy. …”
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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy by Zhaocheng Dong, Zhiyuan Liu, Haoran Dai, Wenbin Liu, Zhendong Feng, Qihan Zhao, Yu Gao, Fei Liu, Na Zhang, Xuan Dong, Xiaoshan Zhou, Jieli Du, Guangrui Huang, Xuefei Tian, Baoli Liu

“…Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. …”
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Endometriosis Associated with Periodontal Disease: Two Case Reports by Shahad Mohammed Halawani, Salah Nasser Alokaili, Alhassan Mohammed Ajeebi, Pradeep Koppolu

“…Both are defined by chronic inflammatory diseases linked to a compromised immune response. The concurrent alteration of immune modulator levels in individuals with endometriosis and periodontal disease led us to examine this relationship in the case reports.…”
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The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk by Xueyi Zhu, Jie Cui, La Yi, Jingjing Qin, Wuniqiemu Tulake, Fangzhou Teng, Weifeng Tang, Ying Wei, Jingcheng Dong

“…Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. …”
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Resistance mechanisms matter in SIR models by Timothy C. Reluga, Jan Medlock

“…We compare four SIR-style modelsdescribing behavioral or immunological disease resistance thatmay be both partial and temporaryin parameter regions feasible for interpandemic influenza.For the models studied, backward bifurcations andbistability may occur in contexts where resistance isdue to behavior change, but they do not occur when resistanceoriginates from an immune response. Care must be exercisedto ensure that modeling assumptions about resistance areconsistent with the biological mechanisms under study.…”
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