The landscape of cell regulatory and communication networks in the human dental follicle by Jia-Ning Liu, Jia-Ning Liu, Jiong-Yi Tian, Lu Liu, Lu Liu, Yuan Cao, Yuan Cao, Xiao Lei, Xiao Lei, Xiao-Hui Zhang, Xiao-Hui Zhang, Zi-Qi Zhang, Zi-Qi Zhang, Jun-Xi He, Jun-Xi He, Chen-Xi Zheng, Chao Ma, Sheng-Feng Bai, Bing-Dong Sui, Fang Jin, Ji Chen, Ji Chen

“…Gene regulatory networks (GRNs) were established and defined four regulon modules underlying dental tissue development and microenvironmental regulation, including vascular and immune responses. Cell–cell communication analysis unraveled crosstalk between vascular and immune cell components in orchestrating dental follicle biological activities, potentially based on COLLAGAN-CD44 ligand–receptor pairs, as well as ANGPTL1-ITGA/ITGB ligand–receptor pairs.ConclusionWe establish a landscape of cell regulatory and communication networks in the human dental follicle, providing mechanistic insights into the cellular regulation and interactions in the complex dental follicle tissue microenvironment.…”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…Conclusion These findings demonstrate the potential of LRH‐1/NR5A2 activation to modulate immune responses and support beta cell viability in T1D, suggesting a new therapeutic approach. …”
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Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression by Carolina Cubillos-Zapata, Enrique Hernández-Jiménez, José Avendaño-Ortiz, Victor Toledano, Anibal Varela-Serrano, Isabel Fernández-Navarro, Raquel Casitas, Carlos Carpio, Luis A. Aguirre, Francisco García-Río, Eduardo López-Collazo

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Effects of female sexual chemosignals on mucosal immunity in BALB/c and C57BL/6 male mice by G. V. Kontsevaya, E. A. Litvinova, M. P. Moshkin

“…The immune response to immunogenic stimuli depends on various factors like cytokine context, way of entry, and immune status of the organism. …”
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Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer by Patrizia Pellegrini, Ida Contasta, Tiziana Del Beato, Fabiana Ciccone, Anna Maria Berghella

“…Our results show that the interferon (IFN)γ production pathway for immune response homeostasis is specific to men whilst the interleukin- (IL-) 6 production pathway for immune response homeostasis is specific to women. …”
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A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis by Suman Ganguli, David Gammack, Denise E. Kirschner

“…The immune response to Mycobacterium tuberculosis infection (Mtb) is the formation of unique lesions, called granulomas. …”
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From the curricular to the investigative, a look at COVID-19 by Sandra Williams Serrano, Luis Alberto Mass Sosa, Milagros León Regal, José Aurelio Díaz Quiñones

“…The objective of this work is to assess the significance of the subject for the interpretation of the deviations of the immune response and to make suggestions to enhance the research work in it.…”
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Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 by Luciana D’Apice, Valerio Costa, Rossella Sartorius, Maria Trovato, Marianna Aprile, Piergiuseppe De Berardinis

“…RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response.…”
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Immunogenicity of RSV F DNA Vaccine in BALB/c Mice by Erdal Eroglu, Ankur Singh, Swapnil Bawage, Pooja M. Tiwari, Komal Vig, Shreekumar R. Pillai, Vida A. Dennis, Shree R. Singh

“…Our data evidently showed that the RSV F DNA vaccine activated the Th1 biased immune response and led to the production of neutralizing antibodies, which is the desired immune response required for protection from RSV infections.…”
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Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease by Daniel Feijó, Rafael Tibúrcio, Mariana Ampuero, Cláudia Brodskyn, Natalia Tavares

“…Initially, DCs were described to play a protective role in activating the immune response against Leishmania parasites. However, several reports showed a dichotomic role of DCs in modulating the host immune response to susceptibility or resistance in CL. …”
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Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome by Kishan Kumar Nyati, Kashi Nath Prasad

“…Herein, we discuss the crucial role of host factors such as cytokines and TLRs that activate the immune response and are involved in the pathogenesis of the disease.…”
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Activated neutrophils: A next generation cellular immunotherapy by Ninad Kumbhojkar, Samir Mitragotri

“…Activated neutrophils also possess the potential to stimulate the downstream immune response and are described as essential effectors in the immune response to tumors. …”
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Nonprotein Structures from Mycobacteria: Emerging Actors for Tuberculosis Control by Luz M. Lopez-Marin

“…Immune response to Mycobacterium tuberculosis, the causal agent of tuberculosis, is critical for protection. …”
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Assessment of heat-killed E. coli expressing Chikungunya virus E2 protein as a candidate vaccine for dual protection against Chikungunya virus and E. coli by Surajit Patra, Surajit Patra, Virendra Gajbhiye, Virendra Gajbhiye, Yogesh A. Karpe, Yogesh A. Karpe

“…Similarly, the vaccine formulation also elicited a significantly higher IgG immune response against E. coli. The results suggested that expressing CHIKV E2 protein in E. coli is a potential approach for generating an IgG immune response against CHIKV and E. coli both. …”
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Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection. by Michael Schoefbaenker, Theresa Günther, Eva Ulla Lorentzen, Marie-Luise Romberg, Marc Tim Hennies, Rieke Neddermeyer, Marlin Maybrit Müller, Alexander Mellmann, Chiara Robin Bojarzyn, Georg Lenz, Matthias Stelljes, Eike Roman Hrincius, Richard Vollenberg, Stephan Ludwig, Phil-Robin Tepasse, Joachim Ewald Kühn

“…We studied the humoral immune response causing intra-host evolution in a B-cell depleted, haemato-oncologic patient experiencing clinically severe, prolonged SARS-CoV-2 infection with a virus of lineage B.1.177.81. …”
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On the global dynamics of a model for tumor immunotherapy by Denise E. Kirschner, Alexei Tsygvintsev

“…A mathematical model wasdeveloped that explored the immune response to tumors that was used to study a special type of treatment[3]. …”
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Stability of Virus Infection Models with Antibodies and Chronically Infected Cells by Mustafa A. Obaid, A. M. Elaiw

“…Two virus infection models with antibody immune response and chronically infected cells are proposed and analyzed. …”
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Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses by Roberta Santarelli, Marisa Granato, Alberto Faggioni, Mara Cirone

“…We summarized the most recent findings on the role of autophagy in antiviral immune response. We described how viruses have developed strategies to subvert the autophagic process. …”
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Toll Like Receptors 4 and 2 Expression in the Bronchial Mucosa of Patients with Cystic Fibrosis by Hans-Peter Hauber, Meri K Tulic, Anne Tsicopoulos, Benoit Wallaert, Ron Olivenstein, Patrick Daigneault, Qutayba Hamid

“…Recently, toll-like receptor (TLR) 4 has been shown to be responsible for the lipopolysaccharide (LPS)-mediated immune response. While TLR2 mediates responses driven by bacterial lipoproteins and peptidoglycans from Gram-positive bacteria, LPS derived from P aeruginosa may stimulate the immune response in the airways of patients with CF via activation of TLR4.…”
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Resistance to P. brasiliensis Experimental Infection of Inbred Mice Is Associated with an Efficient Neutrophil Mobilization and Activation by Mediators of Inflammation by Felipe Fornias Sperandio, Gisele Pesquero Fernandes, Ana Carolina Silvério Cerqueira Mendes, Giulia Maria de Alencar Castro Bani, Vera Lucia Garcia Calich, Eva Burger

“…Patients may respond differently to PCM depending on the pattern of the acquired immune response developed. The onset of protective immune response is notably mediated by neutrophils (PMN) that play an important role through directly killing the fungi and also by interacting with other cell types to modulate the acquired protective immune response that may follow. …”
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