Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study by Simona Truglia, Simona Truglia, Francesco Ciccia, Silvia Mancuso, Antonella Capozzi, Aroldo Rizzo, Francesca Romana Spinelli, Fulvia Ceccarelli, Tania Colasanti, Cristina Garufi, Francesca Miranda, Maurizio Sorice, Cristiano Alessandri, Fabrizio Conti

“…Interleukin-32 (IL-32), a cytokine involved in both innate and adaptive immune responses, has been widely considered in autoimmune-inflammatory rheumatic diseases. …”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…TLR2 pathway activation in myeloid cells contributes to TNF‐α secretion and could influence adaptive immune responses.…”
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Immunomodulatory Effects Mediated by Dopamine by Rodrigo Arreola, Samantha Alvarez-Herrera, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Carlos Cruz-Fuentes, Enrique Octavio Flores-Gutierrez, María Eugenia Garcés-Alvarez, Dora Luz de la Cruz-Aguilera, Emilio Medina-Rivero, Gabriela Hurtado-Alvarado, Saray Quintero-Fabián, Lenin Pavón

“…In clinical conditions such as schizophrenia, Parkinson disease, Tourette syndrome, and multiple sclerosis (MS), there are evident alterations during immune responses in leukocytes, in which changes in DA receptor density have been observed. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Although previous studies have shown that IRAK3 is involved in immune responses, the potential effects of IRAK3 on ICH remain unclear.Methods: Collagenase IV–induced ICH mouse model. …”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…Since tumor immune escape mechanisms do not impact pre-existing and consolidated immune responses, we tested the hypothesis of redirecting a pregenerated immunity to cancer: to recall a non-tumor antigen response against the tumor, silk fibroin nanoparticles (SFNs) have been selected as ‘Trojan-horse’ carriers, promoting the antigen uptake by the tumor cells.Methods SFNs have been loaded with either ovalbumin (OVA) or CpG oligonucleotide (CpG) as antigen or adjuvant, respectively. …”
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The multi-omics signatures of telomere length in childhood by Congrong Wang, Dries S. Martens, Mariona Bustamante, Rossella Alfano, Michelle Plusquin, Lea Maitre, John Wright, Rosemary R. C. McEachan, Johanna Lepeule, Remy Slama, Marina Vafeiadi, Leda Chatzi, Regina Grazuleviciene, Kristine B. Gutzkow, Hector Keun, Eva Borràs, Eduard Sabidó, Angel Carracedo, Georgia Escarami, Augusto Anguita-Ruiz, Dolors Pelegrí-Sisó, Juan R. Gonzalez, Martine Vrijheid, Tim S. Nawrot

“…Conclusions Findings of this multi-omics study suggested an intricate interplay between telomere length, metabolism and immune responses, providing valuable insights into the molecular underpinnings of the early-life biological aging.…”
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Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-in... by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…Overall, our study provides valuable insights into the therapeutic potential of XYP injection in treating influenza, highlighting its multifaceted effects on host microbiota and immune responses, and pinpointing SerpinB2/PAI-2 as the target for XYP injection in exerting anti-inflammatory and antiviral therapeutic mechanisms.…”
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Genome-Wide Comprehensive Identification and In Silico Characterization of Lectin Receptor-Like Kinase Gene Family in Barley (Hordeum vulgare L.) by Fee Faysal Ahmed, Farah Sumaiya Dola, Md Shohel Ul Islam, Fatema Tuz Zohra, Nasrin Akter, Shaikh Mizanur Rahman, Md. Abdur Rauf Sarkar

“…They play crucial roles in plant growth, development, immune responses, signal transduction, and stress tolerance. …”
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Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice by Robert G. Martindale, Philip C. Calder, Sarah V. Cogle, David C. Evans, Leah Gramlich, Stephen A. McClave, Manpreet S. Mundi, Maurizio Muscaritoli, Reid Nishikawa, Jayshil Patel, Lorenzo Pradelli, Martin Rosenthal, Christian Stoppe, Kelly A. Tappenden, Malissa Warren, Dan Waitzberg, Paul E. Wischmeyer, Stanislaw Klek

“…In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. Moreover, fish oil (FO), which contains omega-3 fatty acids, has become an important component of modern lipid emulsions. …”
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Single-cell RNA sequencing of the spleen reveals differences in Salmonella typhimurium infection mechanisms between different chicken breeds by Qi Zhang, Qiao Wang, Jumei Zheng, Jin Zhang, Gaomeng Zhang, Fan Ying, Dawei Liu, Jie Wen, Qinghe Li, Guiping Zhao

“…This study represents the first single-cell transcriptomic analysis of chicken spleen and compares the immune responses of Beijing-You and Cobb after bacterial infection. …”
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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…This virus induces strong immune responses that provide high levels of protection against infection with the deadly parental virus.…”
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Probiotic properties of Bacillus licheniformis HN318 and comparison of the effects of its bacterial cells and cultures on growth, immunity and disease resistance of hybrid grouper... by Zhenjie Cao, Qiaoli Yang, Aie Kang, Guotao Wang, Pengshuo Li, Guiping Qiu, Jinge Wang, Chunsheng Liu, Yun Sun, Yun Sun, Yun Sun

“…Hybrid grouper were fed with HN318 cultures and bacterial cells for 8 weeks, and their growth, feed utilization, immune responses, and survival rates upon challenge with Vibrio harveyi were evaluated. …”
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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis by Xiang Li, Gao He, Hui Jin, Xinyu Xiang, Dong Li, Renmiao Peng, Jing Tao, Xinping Li, Kaiyang Wang, Yu Luo, Xiaoan Liu

“…This sono‐immnotherapy approach demonstrated excellent outcomes in tumor inhibition, eliciting immune responses, and reducing pulmonary fibrosis. Overall, this study offers a new, efficient, and safe method for breast cancer treatment, and expands the application of immunotherapy.…”
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Evaluating the use of Uromune® autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain by Simona Iftimie, Paula Ladero-Palacio, Ana F. López-Azcona, Laia Pujol-Galarza, Antoni Pont-Salvadó, Xavier Gabaldó-Barrios, Jorge Joven, Jordi Camps, Antoni Castro, Mercè Pascual-Queralt

“…The Uromune®, a sublingual, heat-inactivated, polybacterial vaccine, represents a promising therapeutic alternative by enhancing immune responses against uropathogens. Methods This pilot retrospective study, conducted at Hospital Universitari de Sant Joan de Reus from January 2018 to August 2022, assessed the association between Uromune® administration and changes in recurrent UTIs. …”
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Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont... by Ali Faisal Saleem, Visalakshi Jeyaseelan, Zaubina Kazi, Mahjabeen Zehra, Muhammad Masroor Alam, Grace Macklin, Rocio Lopez Cavestany, Sajid Muhammad, Najeeb Rehman, Ondrej Mach

“…We assessed the humoral and mucosal immune responses in children who received two doses of tOPV (during vaccination campaigns) in Karachi, Pakistan. …”
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Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving by J. Gao, T.N. Marins, J.O.S. Calix, Z. Qi, C.G. Savegnago, A.M. Roper, M.W. Woldemeskel, J.K. Bernard, S. Tao

“…The concurrent increases in immune cell infiltration and mammary cell proliferation in the mammary gland following dry-off suggest an association between mammary immune responses and growth during the early dry period.…”
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A Model H5N2 Vaccine Strain for Dual Protection Against H5N1 and H9N2 Avian Influenza Viruses by Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Kang-Seuk Choi

“…Furthermore, we demonstrated that M2e-specific immune responses, difficult to induce with inactivated vaccines, can be effectively elicited with live vaccines, suggesting a strategy to enhance M2e immunogenicity in whole influenza virus vaccines. …”
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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…However, utilising tailored biomimetic three-dimensional (3D) topological porous structures combined with multiple bio-effect neurotrophic factors to create environments similar to neural tissues, regulate local immune responses, and develop a supportive microenvironment to promote peripheral nerve regeneration and repair poses significant challenges. …”
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Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota by Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight

“…Dendritic cells regulate immune responses to microbial products and play a key role in ulcerative colitis (UC) pathology. …”
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Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway by Shenghe Deng, Huan Cao, Tongxi Li, Xueling Wang, Junpeng Meng, Teng Zeng, Di Zhang, Shuhua Zhang, Guoliang Wang, Ran Liu, Tianhao Zou, Mao Cai, Ren Lang, Di Lu, Jinyang Gu

“…Dysbiosis of the gut microbiota has been implicated in modulating IRI, and Lachnospiraceae plays a pivotal role in regulating host inflammatory and immune responses, but its specific role in liver transplantation IRI remains unclear. …”
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