Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma by Chun Wai Wong, Rotem Leshem, Kieran Neil Sefton, I-Hsuan Lin, Dervla Tamara Isaac, Mario Niepel, Adam Hurlstone

“…Despite the enhanced immune responses, tumor cells developed adaptive resistance by engaging alternative immune evasion pathways.Conclusions Although adaptive resistance mechanisms re-emerge, PARP14 inhibition combined with PD-1 blockade offers a promising strategy to enhance treatment outcomes and overcome ICI resistance in melanoma, as immune cells are primed for further therapeutic interventions that leverage the quiescent state.…”
Get full text

Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma by Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi

“…Furthermore, this vaccine displayed the capacity to modulate humoral and cellular immune responses. Overall, the results suggest therapeutic potential for the chimeric CD70-CPP-TNF vaccine against RCC. …”
Get full text

Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma by Hua Ruheng, Yu Pengfei, Zheng Wanting, Wu Nuwa, Yu Wangjianfei, Kong Qingyu, He Jun, Qin Lei

“…It plays a role in modulating inflammatory and immune responses. In this study, we find that Tim-1 is overexpressed in hepatocellular carcinoma (HCC) samples and that its expression is significantly correlated with postoperative survival. …”
Get full text

Skin Cell and Tissue Responses to Cross-Linked Hyaluronic Acid in Low-Grade Inflammatory Conditions by Benjamin Sanchez, Sandra Ferraro, Audrey Josset-Lamaugarny, Aurélie Pagnon, Charlie K. Hee, Lauren Nakab, Dominique Sigaudo-Roussel, Bérengère Fromy

“…We hypothesized that cross-linked HA and its degradation products, in a low-grade inflammatory microenvironment, could impact immune responses that could affect cell behaviours in the dermis. …”
Get full text

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…Interleukin-1β (IL-1β) is a pleiotropic cytokine and a crucial mediator of inflammatory and immune responses. IL-1β processing and release are tightly controlled by complex pathways such as NF-kB/ERK1/2, to produce pro-IL-1β, and NALP3/ASC/Caspase-1 inflammasome, to produce the active secreted protein. …”
Get full text

Parasite-Specific IL-17-Type Cytokine Responses and Soluble IL-17 Receptor Levels in Alveolar Echinococcosis Patients by Christian J. Lechner, Beate Grüner, Xiangsheng Huang, Wolfgang H. Hoffmann, Peter Kern, Peter T. Soboslay

“…These observations suggest immune-modulating properties of E. multitocularis on lL-17 cytokine-mediated pro-inflammatory immune responses; this may facilitate the tissue infiltrative growth of the parasite and its persistence in the human host.…”
Get full text

Genetics of Inflammatory Bowel Disease: Current Understanding and Future Directions by P. K. Chandra Sekar, R. Veerabathiran

“…Genetic variants, including NOD2, ATG16L1, and IL23R, contribute to dysregulation of immune responses, epithelial barrier function, and mucosal homeostasis. …”
Get full text

Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

“…The immune response following trauma represents a major driving force of organ dysfunction and poor outcome. …”
Get full text

Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. …”
Get full text

Identification and Characterization of the <i>LecRLKs</i> Gene Family in Maize, and Its Role Under Biotic and Abiotic Stress by Xiangbo Yang, Ziqi Chen, Jianyu Lu, Xuancheng Wei, Yanying Yao, Wendi Lv, Jiarui Han, Jianbo Fei

“…It can rapidly respond to both biotic and abiotic stresses while mediating mechanisms of plant immune responses. This study represents the first identification of the LecRLK family genes in maize. …”
Get full text

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression by Michela Cioni, Christian Mittelholzer, Marion Wernli, Hans H. Hirsch

“…BKV agnoprotein is abundantly expressed late in the viral life cycle, but specific cellular and humoral immune responses are low or absent. We hypothesized that agnoprotein might contribute to BKV immune evasion by downregulating HLA expression, similar to Herpes simplex virus-1 ICP47. …”
Get full text

Immunotherapy against glioblastoma using backpack‐activated neutrophils by Tatsuya Fukuta, Ninad Kumbhojkar, Supriya Prakash, Suyog Shaha, A. Da Silva‐Candal, Kyung Soo Park, Samir Mitragotri

“…The combination treatment of NE/CAMPs and aPD‐1 activated systemic immune responses mediated by T cells and showed improved therapeutic responses compared with aPD‐1 alone in the orthotopic GBM model. …”
Get full text

Dietary Niacin Requirement of Juvenile Chinese Mitten Crab, Eriocheir sinensis by Xuran Liu, Wenlong Wan, Mengge Li, Jiayuan Shi, Jie Xu, Zihan Zhou, Anran Wang, Shuyan Miao

“…Additionally, moderate dietary niacin levels significantly affected the nonspecific immune responses of crabs, by improving the activity of catalase (CAT), glutathione s-transferase (GST), glutathione peroxidase (GSH-Px), and total superoxide dismutase (T-SOD) (p<0.05). …”
Get full text

Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…Further in vivo investigations revealed that PGEVs efficiently accumulated in 4T1 tumors and exerted significant therapeutic effects through boosting systemic anti-tumor immune responses and modulating the gut microbiota whether administered orally or intravenously (i.v.). …”
Get full text

Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB by Bai Y, Wang X, Wang B

“…PDGFB, which is involved in various immune responses, influences the malignant characteristics of various cancer types and controls immune cell infiltration. …”
Get full text

Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

“…Predictions using the C-ImmSim server suggest that TgROP18 can stimulate humoral and cell-mediated immune responses, based on antibody titers and cytokine profiles following antigen administration. …”
Get full text

The Role of Macrophages in the Pathogenesis of Celiac Disease by A. I. Khavkin, E. V. Loshkova, E. I. Kondratieva, N. S. Shapovalova, I. R. Grishkevich, I. V. Doroshenko, G. N. Yankina

“…Impaired macrophage function/differentiation results in either inadequate, excessive immune activation or failure to mount effective protective immune responses against pathogens, which may result in the development of gastrointestinal diseases. …”
Get full text

Strategic and Technical Considerations in Manufacturing Viral Vector Vaccines for the Biomedical Advanced Research and Development Authority Threats by Lindsay A. Parish, Shyam Rele, Kimberly A. Hofmeyer, Brooke B. Luck, Daniel N. Wolfe

“…In many instances, vaccines may be needed in a reactive scenario, requiring technologies than can elicit rapid and robust immune responses with a single dose. Here, we discuss how viral vector vaccines are utilized in a vaccine portfolio for priority biological threats, some of the challenges in manufacturing viral vector vaccines, the need to strengthen live virus manufacturing capabilities, and future opportunities to capitalize on the use of viral vectors to improve the sustainability of the Biomedical Advanced Research and Development Authority’s vaccine portfolio.…”
Get full text

The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy by Guandu Li, Xiangyu Che, Shijin Wang, Dequan Liu, Deqian Xie, Bowen Jiang, Zunwen Zheng, Xu Zheng, Guangzhen Wu

“…Cisplatin can augment anti-tumor immune responses in combination with immune checkpoint blockers (such as PD-1/PD-L1 or CTLA4 inhibitors), lipid metabolism disruptors (like FASN inhibitors and SCD inhibitors) and nanoparticles (NPs), resulting in better outcomes. …”
Get full text

Human induced pluripotent stem cell–derived therapies for regeneration after central nervous system injury by Stephen Vidman, Yee Hang Ethan Ma, Nolan Fullenkamp, Giles W. Plant

“…Furthermore, successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support integration. Lastly, host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for immunosuppression. …”
Get full text