NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome by Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Tara Kenny, Christopher Morehouse, Carolina Caceres, Paul Warrener, Ventzislava A. Hristova, Susan Wilson, Harini Shandilya, Arnita Barnes, Alexey Ruzin, Junmin Wang, Lisa Oberg, Bastian Angermann, Christopher McCrae, Adam Platt, Daniel Muthas, Sonja Hess, Christine Tkaczyk, Bret R. Sellman, Kristoffer Ostridge, Maria G. Belvisi, Tom M. A. Wilkinson, Karl J. Staples, Antonio DiGiandomenico, on behalf of the MICA II Study Group

“…We report that differences in host immune responses and NTHi-killing activity are associated with microbiome changes in mild-to-moderate COPD. …”
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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a... by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

“…Summary: Background: mRNA-based cancer vaccines show promise in triggering antitumour immune responses. To combine them with existing immunotherapies, the intratumoral immune microenvironment needs to be deeply characterised. …”
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Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears by Junjie Chen, Zihe Wang, Ming Yi, Yi Yang, Mengzhao Tian, Yinqi Liu, Guoyou Wang, Huarui Shen

“…As a result, the healing process of rotator cuff injuries faces significant challenges.Bone marrow-derived mesenchymal stem cell exosomes (BMSC-exos) have emerged as a prominent focus of research within the field of bioengineering, owing to their remarkable potential to regulate cellular proliferation and differentiation, modulate immune responses, and facilitate tissue repair and regeneration following cellular damage. …”
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Prebiotic emergent sources for aquaculture: Microalgae and insects by Mónica Vanessa Oviedo-Olvera, Ana Angélica Feregrino-Pérez, María Isabel Nieto-Ramírez, Marta Montserrat Tovar-Ramírez, Humberto Aguirre-Becerra, Juan Fernando García-Trejo

“…Functional food development for fish nourishment includes ingredients containing bioactive compounds, such as prebiotics, that generate favorable immune responses. Non-digestible oligosaccharides function as growth promoters of the intestinal microbiota, improving nutrient absorption and enhancing the fish immune system. …”
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The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game by Donika Ivanova, Severina Semkova, Boncho Grigorov, Milena Tzanova, Ana Georgieva, Dancho Danchev, Biliana Nikolova, Zvezdelina Yaneva

“…In the first part, the focus is on the Warburg effect and redox metabolism during macrophage polarization, cancer development, and management of the immune response by the cancer cells. The second part addresses the possibility of impacts on the Warburg effect through targeting peroxisome proliferator-activated receptors (PPARs). …”
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Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients by Othman Abdul-Malak, Yoram Vodovotz, Akram Zaaqoq, Jesse Guardado, Khalid Almahmoud, Jinling Yin, Brian Zuckerbraun, Andrew B. Peitzman, Jason Sperry, Timothy R. Billiar, Rami A. Namas

“…Multiple mediators of the innate and lymphoid immune responses in the BD ≥ 4 group were elevated differentially upon admission and up to 16 h after injury. …”
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Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis by Sandra Lilliebladh, Åsa Johansson, Åsa Pettersson, Sophie Ohlsson, Thomas Hellmark

“…T cell-mediated immune responses are thought to play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAV). …”
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Design of a Multiepitope Pan-Proteomic mRNA Vaccine Construct Against African Swine Fever Virus: A Reverse Vaccinology Approach by Ella Mae Joy S. Sira, Lauren Emily Fajardo, Edward C. Banico, Nyzar Mabeth O. Odchimar, Fredmoore L. Orosco

“…Immune simulations demonstrated successful induction of immune responses and generation of antigen-specific memory cells. …”
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Galectin 9 rescues the inducibility of IL-10 expression in regulatory B cells of patients with food allergy by Huang Huang, Minyao Li, Shuo Song, Shiyu Feng, Xiaoyang Feng, Yu Liu, Pingchang Yang, Pengyuan Zheng

“…Abstract The deregulation of immune responses is what causes food allergy (FA) to occur. …”
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Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine by Izadiyan Z, Misran M, Kalantari K, Webster TJ, Kia P, Basrowi NA, Rasouli E, Shameli K

“…The integration of immunotherapeutic agents within liposomes marks a paradigm shift, enabling the design of ‘immuno-modulatory hubs’ capable of orchestrating precise immune responses while facilitating theranostic applications. …”
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Interleukin-32γ in the Control of Acute Experimental Chagas Disease by Yarlla L. L. Braga, José R. C. Neto, Arthur W. F. Costa, Muriel V. T. Silva, Marcos V. Silva, Mara R. N. Celes, Milton A. P. Oliveira, Leo A. B. Joosten, Fátima Ribeiro-Dias, Rodrigo S. Gomes, Juliana R. Machado

“…Interleukin-32 (IL-32) plays an important role in inflammation and in the development of Th1/Th17 acquired immune responses. We evaluated the influence of IL-32γ on the immune response profile, pathogenesis of myocarditis in acute experimental CD, and control of the disease. …”
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Examining alternative approaches to antibiotic utilisation: A critical evaluation of phage therapy and antimicrobial peptides combination as potential alternatives by Chibuzo Vincent Alisigwe, Chibuzor Stanley Ikpa, Uchenna Joseph Otuonye

“…However, concerns about phage evolution potentially eliciting human immune responses necessitate additional investigation to enhance phage therapy. …”
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Association between changes in genital immune markers and vaginal microbiome transitions in bacterial vaginosis by Philipp Foessleitner, Briah Cooley Demidkina, Wafae El-Arar, Miles Goldenberg, Meena Murthy, Agnes Bergerat, Ofri Bar, Douglas S. Kwon, Caroline M. Mitchell

“…This prospective study aimed to assess associations between microbial changes and mucosal immune responses in BV patients. Therefore, samples from 20 premenopausal women with BV and treated with metronidazole were analyzed. …”
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Tumor microbiome: roles in tumor initiation, progression, and therapy by Shengxin Zhang, Jing Huang, Zedong Jiang, Huan Tong, Xuelei Ma, Yang Liu

“…Additionally, tumor microbiome is closely associated with drug resistance and influences therapeutic efficacy by modulating immune responses, drug metabolism, and apoptotic pathways. …”
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Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation by Vera Mekers, Mirjam de Visser, Karijn Suijkerbuijk, Clemens Bos, Chrit Moonen, Roel Deckers, Gosse Adema

“…Mechanical High-Intensity Focused Ultrasound (M-HIFU) represents a promising tumor ablative therapy, inducing cavitation within the tumor, resulting in tumor cell destruction and the release of danger signals and tumor antigens, two key factors contributing to anti-tumor immune responses.Methods/Results: Preclinical studies on the impact of M-HIFU on the anti-tumor immune response are guiding the translational application of this technique in the clinical setting. …”
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Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro. by Justin Komguep Nono, Katrien Pletinckx, Manfred B Lutz, Klaus Brehm

“…<h4>Background</h4>Alveolar echinococcosis, caused by Echinococcus multilocularis larvae, is a chronic disease associated with considerable modulation of the host immune response. Dendritic cells (DC) are key effectors in shaping the immune response and among the first cells encountered by the parasite during an infection. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…These analyses suggest that the proposed vaccines may elicit potent immune responses against H. pylori, but laboratory validation is needed to verify their safety and immunogenicity.…”
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Exploring Antibacterial Activity of Fish Protein Hydrolysate In Vitro Against Vibrio Strains and Disease Resistance to V. harveyi in Turbot (Scophthalmus maximus) by Yuliang Wei, Lu Wang, Yanlu Li, Qiang Ma, Mengqing Liang, Houguo Xu

“…Results of the feeding trial showed that FPH enhanced antioxidant and immune responses before V. harveyi challenge as modulating immunoglobulin M (IgM), catalase (CAT), and myeloperoxidase (MPO) activities in serum, as well as the number of goblet cells in the intestine. …”
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CD109, a master regulator of inflammatory responses by Adel Batal, Adel Batal, Setareh Garousi, Setareh Garousi, Kenneth W. Finnson, Kenneth W. Finnson, Anie Philip, Anie Philip

“…CD109 modulates TGF-β and NF-κB pathways, to influence immune responses and inflammation. CD109’s multifaceted role in inflammation spans various tissue types, including the skin, lung, bone and bone-related tissues, and various types of cancers. …”
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The mRNA-1647 vaccine: A promising step toward the prevention of cytomegalovirus infection (CMV) by Adewunmi Akingbola, Abiodun Adegbesan, Olajumoke Adewole, Kolade Adegoke, Akpevwe Emmanuella Benson, Paul Ayomide Jombo, Sandra Uchechukwu Eboson, Victor Oluwasola, Ademola Aiyenuro

“…We have reviewed results from Phase 1 and 2 clinical trials of the mRNA-1647 vaccine, demonstrating robust immune responses in both seronegative and seropositive participants. …”
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