Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma by Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese, Rosa Terracciano, Rosario Maselli

“…Eosinophilic asthma includes either allergic or nonallergic phenotypes underlying immune responses mediated by T helper (Th)2 cell-derived cytokines, whilst neutrophilic asthma is mostly dependent on Th17 cell-induced mechanisms. …”
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Virally-initiated pain states: phenotypes, mechanisms, and future directions by Sara A. Dochnal, Steven P. Cohen, Mark R. Hutchinson, Mark R. Hutchinson, Mark R. Hutchinson, Yury I. Miller, Tony L. Yaksh

“…These virally induced pain states can arise through direct viral replication within neurons, or indirectly, via immune responses to infection in both the contexts of afferent signaling in the dorsal root ganglion (DRG) or subsequent higher order integration in intracranial systems. …”
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Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis by Jun-Qi Yang, Yonghua Zhou, Ram Raj Singh

“…Invariant natural killer T (iNKT) cells are unique subset of innate-like T cells recognizing glycolipids. iNKT cells can rapidly produce copious amounts of cytokines upon antigen stimulation and exert potent immunomodulatory activities for a wide variety of immune responses and diseases. We have revealed the regulatory effect of iNKT cells on autoimmunity with a serial of publications. …”
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Identification of biomarkers associated with ferroptosis in macrophages infected with Mycobacterium abscessus using bioinformatic tools. by Jiahua Qian, Chenghua Lu, Kai Meng, Zhihong Xu, Honghao Xue, Weijie Yang

“…Functional enrichment analysis showed that these genes were involved in immune responses, inflammation, cellular metabolism, cell death, and apoptosis. …”
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Cancer Vaccine by Fusions of Dendritic and Cancer Cells by Shigeo Koido, Eiichi Hara, Sadamu Homma, Yoshihisa Namiki, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri

“…Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Therefore, their use for the active immunotherapy against cancers has been studied with considerable interest. …”
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Emerging insights into intravital imaging, unraveling its role in cancer immunotherapy by Minfeng Yang, Shiqiang Hou, Yao Chen, Hongzhao Chen, Minjie Chu, Song-Bai Liu

“…Currently, several experimental strategies are available to monitor this complexity but most of them fail to facilitate real-time monitoring of the immune response such as cellular phagocytosis and cytolysis. …”
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Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function by Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu

“…Pathway analyses using these DEGs, followed by protein–protein interaction network analysis, revealed key roles of ribosomal function in MCI progression, whereas immune responses, cell cycle, and protein processing in endoplasmic reticulum were involved in AD progression. …”
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Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes by Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi

“…Several lines of evidence suggest that astrocytes play a key role in modulating the immune responses of the central nervous system (CNS) to infections, injuries, or pathologies. …”
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Investigation of genes expression of the JAK/STAT signalling pathway and AMPs in the presence of Borrelia spirochetes in Ixodes ricinus by Magdalena Szczotko, Sandra Antunes, Ana Domingos, Małgorzata Dmitryjuk

“…Ticks have a basic innate immune system and protect themselves from infection through innate immune responses involving pathways such as Janus kinase (JAK) or the signalling transducer activator of transcription (STAT). …”
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Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis by Christopher R. Shaler, Carly Horvath, Rocky Lai, Zhou Xing

“…Therefore, it is of upmost importance to dissect the mechanisms that contribute to the delayed onset of immune responses following M.tb infection. Such knowledge will help design the most effective vaccination strategies against pulmonary TB.…”
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Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology by Emile Youssef, Brandon Fletcher, Dannelle Palmer

“…CRISPR-Cas9, a revolutionary tool in precision medicine, enables precise editing of cancer-driving mutations, enhancing immune responses and disrupting tumor growth mechanisms. …”
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Boosting the human antiviral response in conjunction with natural plant products by Rashmi Srivastava, Neeraj Kumar Dubey, Megha Sharma, Harsha Kharkwal, Rajesh Bajpai, Rakesh Srivastava

“…Various plant natural products (PNPs) known for their antiviral properties have been evaluated for their ability to modulate immune responses and inhibit viral infections. Research has focused on understanding the mechanisms by which these PNPs interact with the human immune system and their potential to complement existing antiviral therapies. …”
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Bioactive compounds of Calotropis gigantea for cancer treatment by Jayalekshmi C, Nishanth Mohan Das, Rajiv Periakaruppan

“…These bioactive compounds exert their effects through multiple mechanisms, including induction of apoptosis, inhibition of cell proliferation, suppression of angiogenesis, and modulation of immune responses. Additionally, C. gigantea compounds have shown synergistic interactions with conventional chemotherapeutic agents, enhancing treatment efficacy and overcoming drug resistance. …”
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Toll-Like Receptor Signaling and Liver Fibrosis by Tomonori Aoyama, Yong-Han Paik, Ekihiro Seki

“…TLR signaling induces potent innate immune responses in these cell types. The liver is constantly exposed to PAMPs, such as LPS and bacterial DNA through bacterial translocation because there is a unique anatomical link, the portal vein system between liver and intestine. …”
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Inferring the energy cost of resistance to parasitic infection and its link to a trade-off by Frédéric Douhard, Carole Moreno-Romieux, Andrea B. Doeschl-Wilson

“…Abstract Background In infected hosts, immune responses trigger a systemic energy reallocation away from energy storage and growth, to fuel a costly defense program. …”
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The role of microalgae in providing essential minerals for sustainable swine nutrition by José A. M. Prates, José A. M. Prates

“…Inclusion rates of 2-5% in swine diets have demonstrated positive outcomes, with C. vulgaris at 3-5% inclusion levels significantly enhancing bone mineral density and growth in piglets, while Limnospira platensis at 2-3% inclusion has been linked to improved immune responses and increased antibody production. In addition to minerals, microalgae contribute bioactive compounds, n-3 polyunsaturated fatty acids and antioxidants that support swine health and productivity. …”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…NPs can stimulate the immune responses of M1-TAMs, DCs, and T cells while reducing the infiltration of immune suppressive cells such as M2-TAMs and Tregs, thereby regulating the AOC immune TME. …”
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The Role of Ubiquitin-Like Interferon (IFN)-Stimulated 15 and IFN Gamma Genes Polymorphism with the Severity and Serum Biochemical Markers in COVID-19 Patients by Khadijah Gatfan Hosseien, Parisa Tahmasebi, Hayder Obayes Hashim, Alaa Tareq Shakir, Zahra Bozorgi Moghadam

“…IFN-gamma (IFN-γ) is a kind of cytokine that plays a significant role in both the induction and regulation of a wide variety of immune responses. Objectives: This study examined the relationships between rs1921 and rs1861494 single nucleotide polymorphisms with the manifestation of coronavirus disease 2019 (COVID-19) symptoms in patients and the status of biochemical markers in previously diagnosed cases. …”
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A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features by Zihan Quan, Songqing Fan, Hongmei Zheng, Yue Ning, Yang Yang

“…MARCH8 has been shown to participate in immune responses. However, the role of MARCH8 in prognosis and immunology in human cancers remains largely unknown. …”
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Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer by Junko Tsuchida, Masayuki Nagahashi, Kazuaki Takabe, Toshifumi Wakai

“…Sphingosine-1-phosphate (S1P) is a pleiotropic, bioactive lipid mediator that regulates many cellular functions, including proliferation, migration, survival, angiogenesis/lymphangiogenesis, and immune responses. S1P is formed in cells by sphingosine kinases and released from them, which acts in an autocrine, paracrine, and/or endocrine manner. …”
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