The link between spreading depolarization and innate immunity in the central nervous system by Kadir Oguzhan Soylu, Muge Yemisci, Hulya Karatas

“…Importantly, these findings indicate that these inflammatory processes may also have systemic implications, affecting immune responses beyond the central nervous system. Overall, this body of work highlights the need for further exploration of the mechanisms underlying SD-induced inflammation and potential therapeutic targets to mitigate neuroinflammatory disorders. …”
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The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets by M. Isabel Palacios-Arreola, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, Jorge Morales-Montor

“…Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effects. …”
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A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules by Tejaswini Masne, Dileep Kumar, Deepali Bansode

“…These mechanisms include disruption of cellular processes within the parasite, interference with DNA replication, and modulation of host immune responses. In addition, the article delves into the effects and side effects of drug therapy, providing an in-depth analysis of their impact on patients. …”
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The Effect of Mycobacterium avium Complex Infections on Routine Mycobacterium bovis Diagnostic Tests by Claire Barry, David Corbett, Douwe Bakker, Peter Andersen, Jim McNair, Sam Strain

“…This study describes the cell-mediated immune responses of cattle exposed to Mycobacterium avium subspecies paratuberculosis (Map) and Mycobacterium avium subspecies avium with particular reference to routine antefmortem Mycobacterium bovis diagnostic tests. …”
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Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design by Muhammad Umar, Haroon Afzal, Asad Murtaza, Li-Ting Cheng

“…The lipidation process is essential for TLR2 recognition and the activation of robust immune responses, positioning lipidated bacterial proteins as potent immunomodulators and adjuvants for vaccines against bacterial-, viral-, and cancer-related antigens. …”
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Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance by Inès Dufait, Therese Liechtenstein, Alessio Lanna, Christopher Bricogne, Roberta Laranga, Antonella Padella, Karine Breckpot, David Escors

“…Recently retroviral and lentiviral vectors have been used to generate tolerogenic dendritic cells, key professional antigen presenting cells that regulate immune responses. Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology. …”
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Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study at a large institution in Singapore by Sapna P Sadarangani, Htet Lin Htun, Weiping Ling, Robert Hawkins, Tsin Wen Yeo, Laura Rivino, Paul A MacAry, Yee-Sin Leo

“…Introduction: Host immune responses may impact dengue severity in adults. …”
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Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…AI-enabled immunology data analysis, including dimensionality reduction, cell population identification, and sample classification, provides unprecedented insights into complex immune responses. The review highlights real-world examples of AI-driven precision medicine platforms and clinical decision support tools in rheumatology. …”
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Effect of Dietary Administration of Green Macroalgae (Ulva intestinalis) on Mucosal and Systemic Immune Parameters, Antioxidant Defence, and Related Gene Expression in Zebrafish (D... by Elaheh Rouhani, Roghieh Safari, Mohammad Reza Imanpour, Seyed Hossein Hoseinifar, Metin Yazici, Ehab El-Haroun

“…This study investigated the effects of adding green macroalgae gutweed (Ulva intestinalis) powder to zebrafish (Danio rerio) feed at different levels on innate immune responses, antioxidant defence, and gene expression. …”
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Plasma MicroRNA Expression Profiles in Psoriasis by Shiju Xiao, Xin Liu, Xiaoxu Wang, Hongpeng Lv, Junbo Zhao, Xinwei Guo, Fuyang Xian, Yunrun Ji, Guangzhong Zhang

“…MicroRNAs (miRNAs) are key regulators of immune responses. Although differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in psoriasis has not been fully illuminated. …”
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An Aloe-Based Composition Constituting Polysaccharides and Polyphenols Protected Mice against D-Galactose-Induced Immunosenescence by Mesfin Yimam, Teresa Horm, Alexandria O’Neal, Ping Jiao, Mei Hong, Qi Jia

“…UP360 was found to improve the immune response as evidenced by stimulation of innate and adaptive immune responses, increase antioxidant capacity as reflected by augmented SOD and Nrf2, and preserve vital immune organs, such as the thymus, from aging-associated damage. …”
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Anodized Ti6Al4V-ELI, electroplated with copper is bactericidal against Staphylococcus aureus and enhances macrophage phagocytosis by Paula Milena Giraldo-Osorno, Adam Benedict Turner, Sebastião Mollet Barros, Robin Büscher, Simone Guttau, Farah Asa’ad, Margarita Trobos, Anders Palmquist

“…Abstract Implants aim to restore skeletal dysfunction associated with ageing and trauma, yet infection and ineffective immune responses can lead to failure. This project characterized the microbiological and host cell responses to titanium alloy with or without electroplated metallic copper. …”
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Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy by George Chigozie Njoku, Cathal Patrick Forkan, Fumie Mitani Soltysik, Peter Lindberg Nejsum, Flemming Pociot, Reza Yarani

“…EVs are nano-sized vesicles that are non-replicating and carry bioactive molecules that modulate immune responses, promote tissue repair, can facilitate drug delivery and, therefore, hold great therapeutic promise. …”
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Using fecal microbiota transplantation for animal health (review) by H. Yu. Drobot, S. K. Shebeko, A. M. Ermakov

“…Fecal microbiota transplantation is a procedure when fecal matter from a healthy donor is administered into the intestinal tract of a recipient in order to restore microbial balance and strengthen immune responses. Mainly, fecal microbiota transplantation increases bacterial diversity and facilitates a growth in beneficial microorganisms. …”
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The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“… Demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and chronic inflammatory demyelinating polyneuropathy (CIDP), are characterized by dysregulated immune responses to self-antigens, leading to myelin loss. …”
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Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity by David C. Stirling, Maria de Miguel Ferrer, Sungwon Kim, Madina Wane, Daniel Kysh, Lisa J. Caproni, John S. Tregoning

“…The interplay between antigen expression and the innate immune response impacts the overall immune response to DNA vaccines. …”
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Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages by P. Allavena, M. Chieppa, G. Bianchi, G. Solinas, M. Fabbri, G. Laskarin, A. Mantovani

“…Several lines of evidence demonstrate that some CLRs can inhibit the immune response. In this study we investigated TAM-associated molecules potentially involved in their immune suppressive activity. …”
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Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy by Yih-Hsin Chang, Jen-Ning Tsai, Tzu-Lin Chen, Kuo-Ting Ho, Hsin-Yi Cheng, Chiao-Wan Hsiao, Ming-Yuh Shiau

“…The study provides evidence to address the roles of IL-4 in mediating whole-body muscle reservoir and glucose metabolism, as well as the interaction between immune responses and energy homeostasis. IL-4 has dual potential to act as an adjuvant therapeutic target for sarcopenia to preserve muscle mass and insulin resistance to improve insulin sensitivity, which implicates the regulation of immune system to the muscle differentiation and exercise performance.…”
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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…Cancer vaccination is performed using antigenic substances to activate tumor-specific immune responses. Immune checkpoint inhibitors can reactivate tumor-specific T cells and develop an antitumor effect by suppressing checkpoint-mediated signaling. …”
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Polymorphism of the cold receptor gene TRPM8 in native populations of Siberia: putative selective role of rs11563208 polymorphism in Northeast Asia by B. A. Malyarchuk, M. V. Derenko

“…The TRPM8 gene encodes the cold-activated receptor TRPM8, which has an important role in cold adaptation as well as in metabolic and immune responses. Previously, it has been found that polymorphic variants of the TRPM8 gene, which are present in human populations, are associated with different cold sensitivity. …”
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