Elegant and Innovative Recoding Strategies for Advancing Vaccine Development by François Meurens, Fanny Renois, Uladzimir Karniychuk

“…Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens. …”
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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention by Kashish Azeem, Sadaf Fatima, Asghar Ali, Ayesha Ubaid, Fohad Mabood Husain, Mohammad Abid

“…Biofilms, composed of structured communities of bacteria embedded in a self-produced extracellular matrix, pose a significant challenge due to their heightened resistance to antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic resistance within bacterial biofilms, elucidating the adaptive strategies employed by microorganisms to withstand conventional antimicrobial agents. …”
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Scrub typhus association with autoimmune biomarkers and clinical implications. by Hwanseung You, Jeongeun Song, Seonglyeong Kim, Sang-Min Oh, Joo-Hee Hwang, Jeong-Hwan Hwang, Wan-Hee Yoo, Yunjung Choi, Chang-Seop Lee

“…The distribution of ANA titers revealed a progressive increase in mean ANA and double-stranded deoxyribonucleic acid Immunoglobulin M (anti-dsDNA IgM) titers as the duration after symptom onset increased, indicating an augmented immune response over time. This trend was observed along with a systematic elevation in median anti-dsDNA IgM titers, highlighting the dynamic nature of immune responses in scrub typhus infection.…”
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Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…Simultaneously, OVT leverages genetically engineered viruses to selectively destroy cancer cells and stimulate robust antitumor immune responses. Despite their potential, gene therapies face challenges, including off-target effects, delivery issues, and ethical concerns. …”
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Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron by Mona M. Hashem, Eman I. Hassanen, Neven H. Hassan, Marwa A. Ibrahim, Marwa Y. Issa, Mohamed A. Farag, Sherif A. Hamdy

“…Results HFM exposure suppressed immune responses and caused organ damage. Notably, the co-administration of PP extract with HFM reversed these effects, indicating its ability to reduce oxidative stress and protect the immune system. …”
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HIFU-CCL19/21 Axis Enhances Dendritic Cell Vaccine Efficacy in the Tumor Microenvironment by Bum-Seo Baek, Hyunmi Park, Ji-Woong Choi, Eun-Young Lee, Seung-Yong Seong

“…This study examines the potential of combining mechanical high-intensity focused ultrasound (M-HIFU) with dendritic cell (DC) vaccines to enhance immune responses against OLFM4-expressing tumors, a CSC marker linked to immune evasion and tumor growth. …”
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Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling by Anon H. Kosaka, Chen-Yu Huang, Zih-Ying Lu, Hua-Zhen Hsing, Amonrat Choonnasard, Rissar Siringo Ringo, Kuo Pin Chuang, Akatsuki Saito

“…Our results illustrated that although the nuclear localization of capsid proteins is conserved, their effects on IFN-β signaling vary by species, revealing the diverse roles of <i>Circoviridae</i> capsid proteins in modulating immune responses.…”
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Sarcoidosis: molecular mechanisms and therapeutic strategies by Danfeng Xu, Xiaohua Tao, Yibin Fan, Yan Teng

“…CD4 + T cells initiate dysregulated immune responses and secrete significant quantities of inflammatory cytokines, including interleukin (IL)-2 and interferon-gamma (IFN-γ), which play a crucial role in modulating the aggregation and fusion of macrophages to form granulomas. …”
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Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae by Sangeetha Prakash, Sudhanshu Agrawal, Dandan Ma, Sudhir Gupta, Ellena M. Peterson, Anshu Agrawal

“…Dendritic cells (DCs) are the initiators and regulators of immune responses. Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans. …”
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A Series of 35 Cutaneous Infections Caused by Mycobacterium marinum in Han Chinese Population by Wenjie Chen, Fangfang Bao, Qing Pan, Tingting Liu, Xiaotong Xue, Hong Liu, Furen Zhang

“…In addition, the clinical characteristics of M. marinum infection were explored and the mechanism of the host immune responses was investigated. The electronic medical records of 35 patients with M. marinum infection were reviewed. …”
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Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies by Min-Hee Yi, Jinkyung Lee, Subin Moon, EunA So, Geonhyeok Bang, Kyung-Sub Moon, Kyung-Hwa Lee

“…<b>Results</b>: Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. <b>Conclusions</b>: Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention.…”
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Research progress on the antiviral immune regulation of ubiquitin ligase F-box family by MENG Xiangbo, LI Tianqi, ZHANG Tong

“…Some FBPs can specifically recognize and degrade interferon pathway-associated signal molecules via the ubiquitin-proteasome pathway, thereby upregulating or inhibiting interferon signals and regulating host-related immune responses. Additionally, some FBPs can recognize and degrade viral proteins via the ubiquitin-proteasome pathway, thereby inhibiting viral replication and transmission. …”
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Exploring potential biomarkers for acute myocardial infarction by combining circadian rhythm gene expression and immune cell infiltration by Xiao Yu, Xiaopeng Zhang, Hazrat Bilal, Chang Shi, Lei Sun

“…Functional enrichment analyses suggest these genes significantly influence cytokine and chemokine production in immune responses. Immune infiltration assessments using ssGSEA indicated elevated levels of neutrophils, macrophages, and eosinophils in AMI patients. …”
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Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination by Darja Kanduc, Candida Fasano, Giovanni Capone, Antonella Pesce Delfino, Michele Calabrò, Lorenzo Polimeno

“…Sequence analyses produced a set of consensus epitopic peptides potentially able to generate specific anti-polio immune responses exempt from cross-reactivity with the human host. …”
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Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes by Evgenii Balakin, Ksenia Yurku, Mark Ivanov, Alexander Izotov, Valeriya Nakhod, Vasiliy Pustovoyt

“…The reviewed publications provided detailed descriptions of the neuroendocrine and cytokine processes underlying immune response suppression under stress. A significant portion of the data confirms that the activation of the hypothalamic–pituitary–adrenal (HPA) axis and subsequent elevation of cortisol levels exert substantial immunosuppressive effects on immune cells, particularly macrophages and lymphocytes, leading to the suppression of innate and adaptive immune responses. …”
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Establishment of Gill-Derived Primary Cell Cultures from Largemouth Bass (<i>Micropterus salmoides</i>) as an Alternative Platform for Studying Host–Virus Interactions by Ziwen Wang, Li Nie, Chenjie Fei, Jiong Chen

“…These findings highlight the utility of the largemouth bass gill-derived primary cell culture as an alternative in vitro system for investigating MSRV pathogenesis and host immune responses, which serves as a stepping stone for improved antiviral strategies in largemouth bass aquaculture.…”
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Nutritional supplementation, combined with a balanced diet and environmental health education, improved the conversion of LTBI and daily nutrient intake by Samsidi Suparman, Fahri Sukmal, Nur Fauziyah Roro, Dewi Maryati, Khairat Fakhrida, Sunanda Putra Egy, Juliastuti Aditya

“…This study evaluates the efficacy of an integrated intervention model in improving specific immune responses and nutrient intake among subjects. This study employed field experimental design and random allocation techniques. …”
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Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation by Xiaoting Liang, Jing Liu, Mimi Li, Fang Lin, Rulin Zhuang, Qingshu Meng, Xiaoxue Ma, Yuanfeng Xin, Xin Gong, Zhiying He, Wei Han, Xiaohui Zhou, Zhongmin Liu

“…Mesenchymal stem cell (MSC) has generated significant interest as potent immune modulators that can regulate excessive immune responses. We hypothesized that intravenous (iv) administration of human umbilical cord-derived MSC (HucMSC) exerts systemic and local anti-inflammation effects, leading to improved heart function after MI. …”
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Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes by Katerina Stechova, Jana Sklenarova-Labikova, Tereza Kratzerova, Pavlina Pithova, Dominik Filipp

“…Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune responses of their newborns. However, questions concerning the impact of other metabolic disturbances on the immune system of T1D mothers (and their newborns) have been raised. …”
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The human‐specific noncoding RNA RP11‐424G14.1 functions at the intersection of sexually dimorphic pathways in inflammation, senescence, and metabolism by Kameron Kennicott, Yun Liang

“…Abstract Sexual dimorphism is a fundamental characteristic of various physiological and pathological processes in humans, including immune responses, senescence, and metabolism. Most studies on the sex bias have focused on sex hormones or female‐biased genes, whereas male‐biased genetic factors remain understudied. …”
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