IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection. by Jan-Eric Turner, Brigitta Stockinger, Helena Helmby

“…Type 2 immune responses are essential in protection against intestinal helminth infections. …”
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Psychiatric presentation in Rasmussen’s encephalitis by Prashant Maravi, Suneel Singh Kushwaha, Riya Gangwal, Dheerendra Mishra, Nimisha Mishra

“…Psychiatric manifestations in RE are often attributed to seizure activity and immune responses. RE presents a complex clinical picture with both neurological and psychiatric manifestations. …”
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Immunoregulation of NKT Cells in Systemic Lupus Erythematosus by Junwei Chen, Meng Wu, Jing Wang, Xiaofeng Li

“…Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and quality of invariant NKT (iNKT) cells showed marked defects in SLE patients in comparison to healthy controls. …”
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Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses by Keigo Nishida, Ryota Uchida

“…Although many molecules involved in these processes have zinc-binding motifs, the molecular mechanisms and the role of zinc in immune responses have not been elucidated. We and others have demonstrated that zinc signaling plays diverse and specific roles in vivo and in vitro in studies using knockout mice lacking zinc transporter function and metallothionein function. …”
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Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier by Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

“…The interaction between cancer-associated fibroblasts (CAFs) and TME influences immune responses, including resistance to immunotherapy. …”
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Skin Immune Landscape: Inside and Outside the Organism by Florence Abdallah, Lily Mijouin, Chantal Pichon

“…This review aims at providing basic background information on the cutaneous immune system from major cellular and molecular players and the impact of its microbiota on the well-coordinated immune responses in host defense.…”
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Adaptive Genetic Traits in Human Populations: Evolutionary Responses to Malaria by Arun Ghosh, Aparna Ajith S, Abhijith Pradeep

“…These traits disrupt the malaria parasite's life cycle or enhance immune responses, thereby protecting against severe disease. …”
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The effects of the ketone body ?-hydroxybutyrate on the neuronal transcriptome by Zayn Cheema, Megan Chen, Dana Poon, Taara Reddy, John Vergis, Sinead O'Donovan

“…Our results suggest that under normal conditions, BHBs primary actions include modulation of cellular neuronal immune responses. …”
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Pain Neuroscience Education for Acute Pain by Adriaan Louw, Teresa Schuemann, Kory Zimney, Emilio J Puentedura

“…However, modern pain science has illuminated the complexity of the human pain experience, incorporating psychosocial elements, nervous system sensitization, immune responses, and structural changes in the brain as factors. …”
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The Role of Intracellular Organisms in the Pathogenesis of Inflammatory Arthritis by Animesh Singh, Sarah Karrar

“…Interest has, therefore, turned to host-pathogen interactions and whether aberrant immune responses to these could explain the development of arthritis. …”
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Cross-Talk between Apolipoprotein E and Cytokines by Hongliang Zhang, Li-Min Wu, Jiang Wu

“…Moreover, apoE modulates inflammatory and immune responses in an isoform-dependent manner. Correspondingly, inflammatory cytokines can either upregulate or downregulate the production of apoE in various tissue types. …”
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Functional Properties and Molecular Architecture of Leukotriene A4 Hydrolase, a Pivotal Catalyst of Chemotactic Leukotriene Formation by Jesper Z. Haeggström, Pär Nordlund, Marjolein M.G.M. Thunnissen

“…In addition, leukotriene B4 modulates immune responses, participates in the host defense against infections, and is a key mediator of PAF-induced lethal shock. …”
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The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease by E. S. Rovai, M. Holzhausen

“…The mechanisms through which PARs can respond to periodontal enzymes and result in appropriate immune responses have until recently been poorly understood. …”
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Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics by Ziyang Ye, Genpeng Li, Jianyong Lei

“…Abstract Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated immune responses. However, within the tumor environment, excessive ICP activation weakens antitumor immunity. …”
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ULACNet-301, OPTIMO protocol: optimizing HPV vaccination regimen for cancer prevention in children and adolescents living with HIV by Delia Pinto-Santini, Emilia M. Jalil, Giovana Teixeira Fernandes, Genevieve Hilaire, Lenka Kolevic, Robinson Cabello, Beatriz Grinsztejn, William Pape, Marie Marcelle Deschamps, Margaret G. House, Emma Brofsky, Vikrant V. Sahasrabuddhe, Sayan Dasgupta, Siavash Pasalar, Margaret M. Madeleine, Joseph Carter, Priya R. Prabhu, Denise Galloway, Ann Duerr

“…Prior studies among individuals without HIV suggest that a single HPV vaccine dose induces humoral immune responses that, while lower than those induced by two or three doses, still confer protection against HPV infection. …”
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Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

“…This review highlights noninvasive biomarkers that predict, diagnose, and assess transplant prognosis by reflecting graft injury, inflammation, and immune responses. For example, donor-derived cell-free DNA (dd-cfDNA) is highly sensitive in detecting early graft injury, whereas gene expression profiling effectively excludes moderate-to-severe acute rejection (AR). …”
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Newcastle Disease Virus Displaying an Ectodomain of Middle East Respiratory Syndrome Coronavirus Spike Protein Elicited Robust Humoral and Cellular Immunity in Mice by Jaturawitt Prasopsiri, Kanjana Srisutthisamphan, Benjamas Liwnaree, Juggragarn Jengarn, Jarin Kramyu, Payuda Hansoongnern, Papon Muangsanit, Nathiphat Tanwattana, Challika Kaewborisuth, Suttipun Sungsuwan, Anan Jongkaewwattana, Nanchaya Wanasen

“…Conclusions: Engineering the MERS-CoV spike protein is crucial for its successful display on NDV particles. The strong immune responses elicited by the NDV-S_MERS vaccine in mice highlight that NDV is a promising, safe, and effective platform for MERS-CoV vaccination.…”
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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…Conversely, TOCP stimulated the mTOR signaling pathway, enhancing phosphorylation of downstream proteins S6K, RHOA, and PKC, consequently promoting immune responses. This study not only clarified the distinct immunotoxic mechanisms of TPHP and TOCP but also provided critical insights into how structural variations in aryl-OPFRs can lead to markedly different immune responses, thereby informing future risk assessments and regulatory strategies for these compounds.…”
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin... by Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani

“…From the transcriptome analysis in PBMCs, this multivariate model was significantly correlated with the gene signatures related to immune responses, such as CD8 T-cell activation/proliferation and proinflammatory immune responses, and 12 amino acid-related genes were differentially expressed between the high-risk and low-risk groups.Conclusions The multivariate model with PFAAs and metabolites in plasma might be useful for stratifying patients who will benefit from PD-1 inhibitors.…”
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Alphaherpesvirus in Pets and Livestock by Shu-Hui Duan, Ze-Min Li, Xue-Jie Yu, Dan Li

“…During infection, herpesviruses not only stimulate innate immune responses in host cells but also interfere with signaling pathways through specific proteins to achieve immune evasion. …”
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