Increased thyroxine levels of patients with allergic rhinitis by Violeta Lokaj-Berisha, Besa Gacaferri Lumezi

“…The study highlights the complex interplay between metabolic, endocrine, and immune responses in respiratory allergies. Elevated serum IgE levels and alterations in thyroid function, particularly among males, suggest potential pathways for targeted therapeutic interventions. …”
Get full text

BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis by He Qian, Cai Yanzhi, Kong Meihua

“…The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. …”
Get full text

Immunological Approaches and Different Strategies for Vaccine Development Against SARS-COV-2 by Muhammed Babakir-Mina

“…On the base on immune response detected in recovered patients, scientists have started to develop the vaccines. …”
Get full text

Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment by Katherine M. Ranard, Bruce Appel

“…Low DHA status is linked to altered immune responses, white matter defects, impaired vision, and an increased risk of psychiatric disorders during development. …”
Get full text

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. by Xiaoyuan Lin, Beibei Fu, Yan Xiong, Na Xing, Weiwei Xue, Dong Guo, Mohamed Zaky, Krishna Pavani, Dusan Kunec, Jakob Trimpert, Haibo Wu

“…In addition to structural proteins such as Spike and Envelope, the functional roles of non-structural and accessory proteins in regulating viral life cycle and host immune responses remain to be understood. Here, we show that open reading frame 8 (ORF8) acts as messenger for inter-cellular communication between alveolar epithelial cells and macrophages during SARS-CoV-2 infection. …”
Get full text

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung by Matthew S. Twigg, Simon Brockbank, Philip Lowry, S. Peter FitzGerald, Clifford Taggart, Sinéad Weldon

“…The general effects of this protease/antiprotease imbalance are impaired mucus clearance, increased and self-perpetuating inflammation, and impaired immune responses and tissue. To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets. …”
Get full text

Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages. by Elaine Carvalho de Oliveira, Rafael Tibúrcio, Gabriela Duarte, Amanda Lago, Léon de Melo, Sara Nunes, Gustavo Gastão Davanzo, Ana Júlia Martins, Bruno Vinagre Ribeiro, Deborah Mothé, Juliana B P Menezes, Patrícia Veras, Natalia Tavares, Pedro M Moraes-Vieira, Cláudia Ida Brodskyn

“…Here, we demonstrate that despite differences in their mechanisms for evading host immune responses, L. amazonensis and L. braziliensis induce comparable disruptions in key metabolic pathways. …”
Get full text

Therapeutic Approaches in COVID-19 Patients: The Role of the Renin-Angiotensin System by Farzaneh Ketabchi, Sina Jamzad

“…However, the administration of COX inhibitors can reduce innate immune responses and have the opposite effect. A few studies suggest benefits of low-dose radiation therapy (LDR) in treating acute respiratory distress syndrome in COVID-19 patients. …”
Get full text

Unraveling the Molecular Mechanisms of Mosquito Salivary Proteins: New Frontiers in Disease Transmission and Control by Jiayin Guo, Xiaoe He, Jianli Tao, Hui Sun, Jing Yang

“…Specific mosquito salivary proteins (MSPs) can promote pathogen transmission through mechanisms that either regulate hosts’ anti-infective immune responses or directly enhance pathogens’ activity. …”
Get full text

TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells by Wenyi Gu, Jiezhong Chen, Lei Yang, Kong-Nan Zhao

“…Tumour necrosis factor-α, interferon-γ and interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours. In this study, we investigated the effects of three cytokines on CD40 expression in Myb-transformed hematological cells and their regulatory roles in promoting these cells into dendritic cells. …”
Get full text

The Decreased Treg Cells Number Associated with Retinal Lesion Size in Ocular Toxoplasmosis by Ovi Sofia, Muna Amalia, Herryanto Thomassawa, Loeki Enggar Fitri, Seskoati Prayitnaningsih, Hani Susianti

“…The imbalance of the immune response is an important factor contributing to the incidence of ocular toxoplasmosis (OT). …”
Get full text

Transcytosis of T4 Bacteriophage Through Intestinal Cells Enhances Its Immune Activation by Amanda Carroll-Portillo, October Barnes, Cristina N. Coffman, Cody A. Braun, Sudha B. Singh, Henry C. Lin

“…Given that phages reside in the same body niches as bacteria, they share the propensity to stimulate or quench immune responses depending on the nature of their interactions with host immune cells. …”
Get full text

Virological Mechanisms in the Coinfection between HIV and HCV by Maria Carla Liberto, Emilia Zicca, Grazia Pavia, Angela Quirino, Nadia Marascio, Carlo Torti, Alfredo Focà

“…A specific cross-talk among HIV and HCV proteins in coinfected patients modulates the natural history, the immune responses, and the life cycle of both viruses. These effects are mediated by immune mechanisms and by a cross-talk between the two viruses which could interfere with host defense mechanisms. …”
Get full text

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. …”
Get full text

Innovative immunotherapies and emerging treatments in type 1 diabetes management by Malek Zarei, Mohammad Abbas Sheikholeslami, Masoud Mozaffari, Yassar Mortada

“…., Anakinra and Etanercept), have shown potential in preserving beta cell function by modulating immune responses. Antigen-dependent strategies focus on inducing immune tolerance to specific beta cell antigens, with mixed results from clinical trials involving autoantigen vaccines like GAD65. …”
Get full text

Recent advances in nutritional metabolism studies on SARS-CoV-2 infection by Yufen Jiang, Linle Xu, Xuexing Zheng, Hongbo Shi

“…By monitoring metabolic changes, infection severity can be predicted early, and modulating these metabolic pathways may help reduce inflammatory responses, improve immune responses, and reduce the risk of thrombosis. Research on the relationship between metabolism and SARS-CoV-2 infection provides an important scientific basis for addressing the global challenge posed by COVID-19, however, further studies are needed to validate these findings and provide more effective strategies for disease control.…”
Get full text

Oral Tolerance: A New Tool for the Treatment of Gastrointestinal Inflammatory Disorders and Liver-Directed Gene Therapy by Yaron Ilan

“…Thus, oral tolerance induces suppressor lymphocytes that mediate immune response downregulation by induction of a shift from a proinflammatory T helper cell type 1 to an anti-inflammatory T helper cell type 2 immune response.…”
Get full text

Development of Delivery Systems Enhances the Potency of Cell-Based HIV-1 Therapeutic Vaccine Candidates by Amin Hadi, Abbas Rastgoo, Maryam Eskandarian, Nooshin Haghighipour, Azam Bolhassani

“…The recent study assessed immune responses generated by MSCs and DCs, which were derived from mouse bone marrow and modified with Nef antigen using novel methods in mice. …”
Get full text

Serum alpha-1 acid glycoprotein and gallstone risk in US adult women: a cross-sectional analysis of the NHANES by Xiaocheng Li, Peiling He

“…BackgroundGallstone disease, a common biliary disorder, is linked to inflammation and immune responses. However, the association between serum alpha-1 acid glycoprotein (AGP), a key inflammatory marker, and gallstone risk remains underexplored.MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 and 2021–2023 cycles were analyzed. …”
Get full text

Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer by Beatriz Ramos, Dakota Rogers

“…Recent advances include the use of gold nanoparticles, TLR agonist-loaded nanoparticles, and exosome-based delivery systems to boost immune responses. Additionally, nanovaccine strategies incorporating tumor-associated antigens and immune adjuvants show potential for personalized cancer immunotherapy. …”
Get full text