Multiple Gene Deletion Mutants of Equine Herpesvirus 1 Exhibit Strong Protective Efficacy Against Wild Virus Challenge in a Murine Model by Stephanie S. Pradhan, Vekataramireddy Balena, Bidhan Chandra Bera, Taruna Anand, Rhushikesh Khetmalis, Aashwina Madhwal, Supriya Kandasamy, Selvaraj Pavulraj, Manju Bernela, Priya Mor, Bhupendra Nath Tripathi, Nitin Virmani

“…Both mutants induced an optimal level of EHV1-specific humoral and cell-mediated immune responses, as determined by virus neutralization assay, ELISA, and immunophenotyping. …”
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Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis by Xiaofang Liu, Bin Li, Yuxi Lin, Xueying Ma, Yingying Liu, Lili Ma, Xiaomeng Ma, Xia Wang, Nanjing Li, Xiaoyun Liu, Xiaohong Chen

“…These genes are pivotal in regulating immune responses, providing new targets and theoretical basis for the early diagnosis and treatment of autoimmune diseases.…”
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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Conclusions This vaccine platform offers an alternative strategy for developing recombinant subunit vaccines against SARS-CoV-2, potentially enhancing immune responses and improving vaccine efficacy. Graphical abstract…”
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Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection by Mark R. Schleiss

“…A better understanding of immune responses that prevent and/or predispose to infection will help in the development of novel vaccine strategies.…”
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The Immunomodulatory Potential of Wharton’s Jelly Mesenchymal Stem/Stromal Cells by Fernanda Vieira Paladino, Juliana de Moraes Rodrigues, Aline da Silva, Anna Carla Goldberg

“…This text highlights information on how WJ-MSC affect immune responses in comparison with other sources of MSC.…”
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Dynamic Roles of RNA and RNA Epigenetics in HTLV-1 Biology by Emily M. King, Amanda R. Panfil

“…Viruses, particularly retroviruses like human T-cell leukemia virus type 1 (HTLV-1), rely heavily on RNA and RNA post-transcriptional modifications to regulate the viral lifecycle, pathogenesis, and evasion of host immune responses. With the emergence of new sequencing technologies in the last decade, our ability to dissect the intricacies of RNA has flourished. …”
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Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex by Susanne Sattler, Hormas Ghadially, Erhard Hofer

“…Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins. …”
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Understanding schizophrenia through animal models: The role of environmental stressors by Manojlović Marina

“…Prenatal exposure to infections, such as bacterial lipopolysaccharides (LPS) and viral components such as poly I:C, activates immune responses that lead to long-lasting structural and functional changes in the brain, including hippocampal atrophy and cortical thinning. …”
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Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity by Alice Li, Okechukwu Ojogho, Alan Escher

“…Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity of APCs like macrophages and DCs to induce and maintain tolerance after phagocytosis of dead cells. …”
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Scorpion Venom and the Inflammatory Response by Vera L. Petricevich

“…Although the pathophysiology of envenomation is complex and not yet fully understood, venom and immune responses are known to trigger the release of inflammatory mediators that are largely mediated by cytokines. …”
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The unexpected role of the STING protein in lipid metabolism by Vila, Isabelle K., Laguette, Nadine

“…Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the activation of inflammatory responses in the presence of cytosolic DNAs. …”
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Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges by Yangjie Gao, Zhe Ji, Jingyu Zhao, Julin Gu

“…In this study, the therapeutic potential of MSCs for FIs was reviewed, including their roles played by secreting antimicrobial peptides, regulating immune responses, and promoting tissue repair. Meanwhile, the status of research on MSCs in FIs and the controversies were also discussed. …”
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Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling by Jiechen Wang, Fengyuan Guo, Guangjin Chen, Jiwei Sun, Qingming Tang, Lili Chen

“…Studies show that the circadian oscillations of these factors in bone ECM potentially influence the interactions between immune responses and bone formation. More importantly, mesenchymal stem cells (MSCs) within the specific microenvironments provide the regenerative potential for tissue remodeling. …”
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Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis by Jiang Chen, Guo Xiao-Zhong, Xing-Shun Qi

“…The effects of specific immunotherapy were compared with those of nonspecific immunotherapy and the meta-analysis was executed with results regarding the overall survival (OS), immune responses data, and serum cancer markers data. The pooled analysis was performed by using the random-effects model. …”
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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts by Zhongsong Zhang, Long Chen

“…Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, and discerningly focusing on cells within the TME situates nanomaterials as formidable tools to transcend the boundaries set by conventional treatments. …”
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Unfolded protein responses in T cell immunity by Wencan Zhang, Xu Cao

“…Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are integral to T cell biology, influencing immune responses and associated diseases. This review explores the interplay between the UPR and T cell immunity, highlighting the role of these cellular processes in T cell activation, differentiation, and function. …”
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The Opportunistic Pathogen Listeria monocytogenes: Pathogenicity and Interaction with the Mucosal Immune System by Markus Schuppler, Martin J. Loessner

“…Here, we discuss recent advances in our understanding of the interaction of L. monocytogenes with the host immune system that triggers the antibacterial immune responses on the mucosal surfaces of the human gastrointestinal tract.…”
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Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity by Güzin Özçifci, Sena Nur Arbağ, Yasemin Kendir-Demirkol, Joshua D Milner

“…Liable genetic alterations lead to signaling pathways and cellular functioning changes, which skew to type-2 immune responses. Elucidation of these pathways and identifying these disorders have the utmost importance, since early identification of some of these disorders significantly changes the prognosis and targeted treatments offer improved outcomes. …”
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Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity by Lucille Rankin, Gabrielle T. Belz

“…While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered opening exciting new directions for investigation. …”
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HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases by Yi Liu, Guo-Bin Zhuang, Xue-Zhi Zhou

“…In this review, we summarize current knowledge on HMGB1 as a ligand that can evoke inflammation and immune responses in ocular diseases.…”
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