Regulated microbe vaccines: from concept to (pre-clinical) reduction to practice by Richard Voellmy, David C Bloom, Nuria Vilaboa

“…The RCCVs were found to induce potent anti-herpetic immune responses in mice. Vaccination with RCCVs expressing an influenza virus hemagglutinin broadly protected animals against lethal influenza virus challenges. …”
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Sterile osteomyelitis: a cardinal sign of autoinflammation by Tiago Borges, João Santos, Sérgio Silva

“…Autoinflammatory bone disorders (ABDs) are characterized by sterile bone inflammation stemming from dysregulated innate immune responses. This review focuses on the occurrence of sterile osteo­myelitis in ABDs and related diseases, notably chronic nonbacterial osteomyelitis (CNO) and its sporadic and monogenic forms, such as deficiency of the interleukin-1 (IL-1) receptor antagonist, Majeed syndrome, CNO related to FBLIM1 mutation, and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome). …”
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DNA Vaccination: Using the Patient's Immune System to Overcome Cancer by Georg Eschenburg, Alexander Stermann, Robert Preissner, Hellmuth-Alexander Meyer, Holger N. Lode

“…Using the patient's own immune system by activation of humoral and cellular immune responses to target the cancer cells has shown first promising results in clinical trials and may allow reduced toxicity standard therapy regimen in the future. …”
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Chain Gangs: New Aspects of Hyaluronan Metabolism by Michael Erickson, Robert Stern

“…., the ability to modulate immune responses through effects on T regulatory cells and, in its fragmented forms, by being able to engage several toll-like receptors. …”
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Th1 Cytokine-Secreting Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and Prospective Use in Immunotherapy of Bladder Cancer by Yi Luo, Jonathan Henning, Michael A. O'Donnell

“…Since evidence supports the T helper type 1 (Th1) response to be essential in BCG-induced tumor destruction, studies have focused on enhancing BCG induction of Th1 immune responses. Although BCG in combination with Th1 cytokines (e.g., interferon-α) has demonstrated improved efficacy, combination therapy requires multiple applications and a large quantity of cytokines. …”
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Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients by Y. Kenan Coban, Murat Aral

“…IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. …”
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A Case of Leukocytoclastic Vasculitis and Associated Conjunctivitis Following MMR Vaccine Administration by Hana I. Nazir, Aubrey A. Hess, Abha Soni, Kathryn A. Potter

“…With the COVID-19 pandemic, more adults are receiving the MMR vaccine, as it may enhance innate immune responses against COVID-19 infection. Here, we report a case of LCV and associated conjunctivitis arising in a patient secondary to immunization with the MMR vaccine. …”
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Advances in Immunotherapy for Melanoma: A Comprehensive Review by Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Adriana López-Barcenas, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Roberto Arenas Guzman

“…In this comprehensive review, we describe recent advancements in the development of immunotherapies for melanoma, with a specific focus on the identification of neoantigens for the prediction of their elicited immune responses. This review is expected to provide important insights into the future of immunotherapy for melanoma.…”
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Gene Therapy Approaches by Ahmed Jumaa Ahmed, Hogir Saadi

“…Non-viral vectors are much less successful than viral vectors, but because of their low immune responses and their broad therapeutic DNA ability, they have advantages. …”
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An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation by Silvia Sedda, Irene Marafini, Michele M. Figliuzzi, Francesco Pallone, Giovanni Monteleone

“…ILCs represent a relatively small population in the gut, but accumulating evidence suggests that these cells could play a decisive role in orchestrating both protective and detrimental immune responses. In this review, we will summarize the present knowledge on the distribution of ILCs in the intestinal mucosa, with particular focus on their role in the control of both infections and effector cytokine response in immune-mediated pathologies.…”
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Effect of dietary Cucurbita pepo extract on performance, hemato-immunological parameters, immune-related gene expression and bacterial resistance in rainbow trout, Oncorhynchus myk... by Kaveh Vakili, Amir Eghbal Khajehrahimi, Behnam Salimi, Shapour Kakoolaki, Arman Ghorbanzadeh

“…The aim of this research was to investigate the effects of Cucurbita pepo extract (CPE) on performance, blood parameters, immune responses, expression of immunity-related gene, and disease resistance in rainbow trout. …”
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Mechanism of modified mRNA structure in COVID-19 vaccines for inducing neutralizing antibodies by Sabighoh Zanjabila, Beti Ernawati Dewi

“…These vaccines also stimulate adaptive immune responses by activating CD4+ and CD8+ T cells, with mRNA functioning as an endogenous antigen. …”
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Concise Review: Mesenchymal Stem Cells Ameliorate Tissue Injury via Secretion of Tumor Necrosis Factor-α Stimulated Protein/Gene 6 by Zhigang He, Jie Hua, Zhenshun Song

“…This suggests that most beneficial effects are largely due to paracrine secretions or cell-to-cell contacts that have multiple effects involving modulation of inflammatory and immune responses. Currently, the therapeutic benefits of MSCs are in part explained by the cells being activated by signals from injured tissues to express an anti-inflammatory protein, tumor-necrosis-factor-α-induced protein 6. …”
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Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game by Paqui G. Través, Alfonso Luque, Sonsoles Hortelano

“…In this paper, we provide an overview of the immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses. Recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are also reviewed.…”
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The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling by Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, Tatsuo Kinashi

“…Abstract The leukocyte integrin LFA1 is indispensable for immune responses, orchestrating lymphocyte trafficking and adhesion. …”
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In vitro studies on the immunomodulatory effects of fulvic acid extract from palm oil empty fruit bunch (OPEFB) by Dimarwanita Firda, Mariya Silmi, Nur Annisa Dewi Fitria, Latisya Silva, Faramitha Yora, Goenadi Didiek Hadjar

“…With an increasing need for sustainable natural therapies, FA has shown promise in treating degenerative diseases by modulating immune responses. The research focused on assessing the immunomodulatory effects of FA by analysing its impact on cytokine production. …”
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Interactions between Temperament, Stress, and Immune Function in Cattle by N. C. Burdick, R. D. Randel, J. A. Carroll, T. H. Welsh

“…., cattle exhibiting greater exit velocity or pen and chute scores) have poorer growth performance, carcass characteristics, and immune responses. Thus, understanding the interrelationship of stress and temperament can help in the development of selection and management practices that reduce the negative influence of temperament on growth and productivity of cattle. …”
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Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease by Cui Zhang, Weigang Shu, Guangxi Zhou, Jian Lin, Feifei Chu, Huili Wu, Zhanju Liu

“…These data indicate that TNF-α plays a critical role in the induction of mucosal inflammatory response, and that blockade of TNF-α modulates intestinal homeostasis through balancing immune responses of neutrophils.…”
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Dendritic Cells and Their Multiple Roles during Malaria Infection by Kelly N. S. Amorim, Daniele C. G. Chagas, Fernando B. Sulczewski, Silvia B. Boscardin

“…Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. …”
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Rheumatoid arthritis associated cytokines and therapeutics modulate immune checkpoint receptor expression on T cells by Dana Emerson, Eve Merriman, Pia P. Yachi

“…In addition, SOC RA therapeutics such as glucocorticoids and TNF inhibitors modulated IR and cytokine expression in the presence of RA synovial fluid.ConclusionsThis study points to an important and intricate relationship between cytokines and IRs in shaping immune responses in autoimmune pathology. The modulation of IR expression by RA-associated cytokines and SOC therapeutics provides new insights for the use of targeted treatments in managing RA pathology.…”
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