Influence of Epinastine Hydrochloride, an H1-Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo by Ken-Zaburo Oshima, Kazuhito Asano, Ken-Ichi Kanai, Miyuki Suzuki, Harumi Suzaki

“…There is established concept that dendritic cells (DCs) play essential roles in the development of allergic immune responses. However, the influence of H1 receptor antagonists on DC functions is not well defined. …”
Get full text

Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis by Ada Corrado, Ilaria Guadagni, Giovanna Picarelli, Angela Variola

“…ABSTRACT Background Immune‐mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), and ulcerative colitis (UC) exemplify prominent IMIDs, each presenting unique challenges for their management, that impact patient's quality of life (QoL). …”
Get full text

Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation and Host–Pathogen Interaction by Dibyasri Barman, Rishi Drolia

“…Caveolin plays a crucial role in internalizing and modulation of host immune responses by Gram-negative bacterial pathogens, such as <i>Escherichia coli</i> K1, <i>Klebsiella pneumoniae</i>, <i>Pseudomonas aeruginosa</i>, and <i>Salmonella enterica</i> serovar Typhimurium. …”
Get full text

From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis by Sara Ahmadi Badi, Samira Tarashi, Abolfazl Fateh, Pejman Rohani, Andrea Masotti, Seyed Davar Siadat

“…It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” …”
Get full text

Characterization of <i>Streptococcus pyogenes</i> Strains from Tonsillopharyngitis and Scarlet Fever Resurgence, 2023—FIRST Detection of M1_UK in Bulgaria by Emma Keuleyan, Theodor Todorov, Deyan Donchev, Ani Kevorkyan, Radoslava Vazharova, Alexander Kukov, Georgi Todorov, Boriana Georgieva, Iskra Altankova, Yordanka Uzunova

“…A mixed pattern of pro- and anti-inflammatory immune responses in patients was observed.…”
Get full text

Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma by Yuchen Zhang, Junnian Zheng, Li Sun, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Renjin Chen, Dafei Chai, Jiawei Wang, Zichun Zhang, Xiaohui Xie

“…Immunization with Ad-Siglec-E/CAIX promoted the induction and maturation of CD11c+ dendritic cells and their subsets, which in turn enhanced tumor-specific CD8+ T cell immune responses, as evidenced by increased CD8+ T cell proliferation and CTL activity. …”
Get full text

Microbial metabolites and immune modulation by Hassan Ghasemi

“…Further research is needed to dissect the precise molecular pathways linking specific metabolites to immune responses, as much remains unknown about their multifaceted roles. …”
Get full text

Immunoinformatic approach to the design of a novel multi-epitope vaccine against Leishmania major fused to human IgG-Fc by Mahmood Fadaie, Zabihollah Shahmoradi, Hossein Khanahmad

“…Cysteine proteases, KMP-11, and HASPB proteins are promising candidates for leishmaniasis vaccine development owing to their immunogenic properties and capacity to provoke robust immune responses, as evidenced by different investigations. …”
Get full text

Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier by Shinobu Watarai, Tana Iwase, Tomoko Tajima, Eiji Yuba, Kenji Kono

“…The usefulness of pH-sensitive fusogenic polymer-(succinylated poly(glycidol)-(SucPG-) modified liposomes as a vaccine carrier in the induction of immune responses was evaluated. Mice were intraperitoneally immunized with ovalbumin- (OVA-) containing SucPG-modified liposomes. …”
Get full text

Bacterial Toxin Fusion Proteins Elicit Mucosal Immunity against a Foot-and-Mouth Disease Virus Antigen When Administered Intranasally to Guinea Pigs by Sreerupa Challa, Steven M. Szczepanek, Debra Rood, Roger W. Barrette, Lawrence K. Silbart

“…However, intranasal administration of antigens along with the appropriate delivery vehicle/adjuvant has been shown to induce mucosal immune responses, and bacterial enterotoxins have long been known to be effective in this regard. …”
Get full text

Immunomodulatory Potential of Piperine in Rats by Alireza Ghavami, Seyyed Meysam Abtahi Froushani, Aliasghar tehrani

“…Conclusion: These findings show that piperine is a modulating agent of innate and acquired immune responses.…”
Get full text

Synbiotic microcapsule dietary supplementation for prevention against co-infection diseases in Pacific white shrimp: a limited field experiment by Munti Yuhana, Andreas Tambun, Widanarni Widanarni, Usamah Afiff

“…Twenty four hours after WSSV injection the shrimps were immersed in the water-containing cells suspension of V. harveyi at the cell’s population dosage of 106 CFU.ml-1. Immune responses were observed for 7 days after experimental infection. …”
Get full text

Chemical and Immunological Characteristics of Aluminum-Based, Oil-Water Emulsion, and Bacterial-Origin Adjuvants by Susana Martiñón, Angel Cisneros, Sergio Villicaña, Ricardo Hernández-Miramontes, Edgar Mixcoha, Psyché Calderón-Vargas

“…This minireview summarizes the mechanisms that classic and novel adjuvants produce to stimulate immune responses.…”
Get full text

The Long-Term Immunity of a Microneedle Array Patch of a SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice by Eun Kim, Muhammad S. Khan, Juyeop Shin, Shaohua Huang, Alessandro Ferrari, Donghoon Han, Eunjin An, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Dohyeon Jeong, Andrea Gambotto

“…Results: The rS1RS09 vaccine elicited stronger immune responses and ACE2-binding inhibition than S1 monomer alone or trimer. …”
Get full text

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Hypofractionation or other modifications of standard fractionation may improve radiation’s ability to promote immune responses to tumors. Other novel delivery options may also affect immune responses, including T-cell activation and tumor-antigen presentation changes. …”
Get full text

Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations by Xenia A. K. Kersting, Nicoletta Momtahen, Klaus Lieb

“…It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication.…”
Get full text

Seaweed extract of Gracilaria verrucosa as an antibacterial and treatment against Vibrio harveyi infection of Litopenaeus vannamei by Mad Rudi, Sukenda Sukenda, Dinamella Wahjuningrum, Wesly Pasaribu, Dendi Hidayatullah

“…In conclusion, the seaweed extract of G. verrucosa has antibacterial activity and can induce the immune responses and resistance of Pacific white shrimp against V. harveyi infection. …”
Get full text

Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L by Lakmal Ranathunga, Sachini Abesinghe, Ji-Won Cha, Niranjan Dodantenna, Kiramage Chathuranga, Asela Weerawardhana, D. K. Haluwana, Nuwan Gamage, Jong-Soo Lee

“…Abstract African swine fever virus (ASFV) is nucleocytoplasmic large DNA arbovirus and encodes many proteins involved in the interaction with host molecules to evade antiviral immune responses. Especially, evasion strategies of type I interferon (IFN-I)-mediated immune responses are crucial for early ASFV replication. …”
Get full text

Induction of translation-suppressive G3BP1+ stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA by Vladimir Majerciak, Zhi-Ming Zheng

“…Together, these data indicate that plasmid DNA triggers innate immune responses in the transfected cells and causes a significant cellular perturbation that should be considered during experiment design and data interpretation.…”
Get full text

A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease by Yin T, Zhang T, Ma L

“…Through further functional analysis, these genes were found to be primarily involved in the activation of inflammation and innate immune responses. Subsequently, six hub genes were determined using five topological algorithms. …”
Get full text