Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection by Yan Wang, Xiaodong Gu, Jianbin Xiang, Zongyou Chen

“…Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.…”
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Cross-protection against homo and heterologous influenza viruses via intranasal administration of an HA chimeric multiepitope nanoparticle vaccine by Yongqiang Zhao, Jia Liu, Chun Peng, Shuangshuang Guo, Bo Wang, Longping Chen, Yating Wang, Haiwen Tang, Liming Liu, Qi Pan, Shiren Li, Jingyu Wang, Dongni Yang, Enqi Du

“…However, seasonal influenza vaccines often elicit strain-specific immune responses and confer little protection against mismatched strains. …”
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Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes by Olivia A. Smith, Brent Fujimoto, Teri Ann S. Wong, Albert To, Troy Odo, Aquena Ball, Brien K. Haun, Hiromi Muramatsu, Ying K Tam, Norbert Pardi, Axel T. Lehrer

“…In this study, we investigated the immune responses generated by various SARS-CoV-2 vaccine platforms in mouse models with obesity and diabetes, focusing on both cell-mediated and humoral immune responses. …”
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The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure by Lili Yu, Zhiwei Feng

“…Elevated levels of inflammatory mediators have been identified in patients with HF, which are primarily manifestations of innate immune responses mediated by pattern recognition receptors (PRRs). …”
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Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma by Zoltán Kellermayer, Sabrin Tahri, Madelon M. E. deJong, Natalie Papazian, Cathelijne Fokkema, Elodie C. G. Stoetman, Remco Hoogenboezem, Gregory vanBeek, Mathijs A. Sanders, Louis Boon, Chelsea Den Hollander, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

“…Progression and therapy response are influenced by this immune environment, highlighting the need for a detailed understanding of endogenous immune responses to malignant plasma cells. Here we used the 5TGM1 murine transfer model of multiple myeloma to dissect early immune responses to myeloma cells. …”
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Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans by Guizhen Wang, Yan Liu, Qianyu Li, Changhui Wang, Wei Fang

“…Attenuated virulence is closely associated with enhanced host immune responses, rather than diminished pathogen fitness alone. …”
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Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential by Kaiying Lv, Qun Liang

“…Macrophages, key modulators of immune responses, play a dual role in both promoting and resolving inflammation. …”
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Regulation of Immune Function by Polyphenols by Sujuan Ding, Hongmei Jiang, Jun Fang

“…In summary, polyphenols can be used to regulate intestinal mucosal immune responses, allergic diseases, and antitumour immunity.…”
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Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment by Loh Teng-Hern Tan, Pendru Raghunath, Long Chiau Ming, Jodi Woan-Fei Law

“…Meanwhile, like most pathogenic mycobacteria, M. marinum evades the host immune responses by invading and replicating inside host cells and it is capable of modulating host immune responses. …”
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Interferons and Interferon Regulatory Factors in Malaria by Sin Yee Gun, Carla Claser, Kevin Shyong Wei Tan, Laurent Rénia

“…Acquired adaptive immune responses control parasite replication and infection-induced pathologies. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…In this study, we conducted a systems serology analysis to investigate changes in humoral immune responses induced by varying doses of the AdCLD-CoV19-1 vaccine in a phase I clinical trial. …”
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Borrelia burgdorferi Tolerance-Associated Changes in Gene Expression of Murine Macrophages by Sophia Chen, Ricki Deng, Anis Hadi, Sara Nandwana, William Ryan, John B. Presloid, R. Mark Wooten

“…Macrophages, key cellular players in the innate immune response, exhibit diminished functionality over time during Bb infection, potentially leading to chronic infection. …”
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Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract by Matthew C. Tunis, Jean S. Marshall

“…Food allergy, other adverse immune responses to foods, inflammatory bowel disease, and eosinophilic esophagitis have become increasingly common in the last 30 years. …”
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A Danger-Theory-Based Immune Network Optimization Algorithm by Ruirui Zhang, Tao Li, Xin Xiao, Yuanquan Shi

“…The danger theory emphasizes that danger signals generated from changes of environments will guide different levels of immune responses, and the areas around danger signals are called danger zones. …”
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Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation by Theresa Placke, Hans-Georg Kopp, Helmut Rainer Salih

“…The ability of the tumor necrosis factor receptor (TNFR) family member GITR to modulate immune responses has been the subject of multiple studies. …”
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Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus by Fangyuan Yang, Yi He, Zeqing Zhai, Erwei Sun

“…Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by excessive inflammatory and immune responses and tissue damage. Increasing evidence has demonstrated the important role of programmed cell death in SLE pathogenesis. …”
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Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era? by Prasan Deep Rath, Swetal Pandey, Rahul Bisaralli

“…Another mechanism is the neural inflammatory reflex that regulates innate and adaptive immune responses and also inhibits the production of a vital inflammatory therapeutic target molecule, known as tumor necrosis factor, for RA. …”
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Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses by Elisabetta Profumo, Brigitta Buttari, Rachele Riganò

“…Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. …”
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Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,... by Malabi M Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar

“…Previously, mucosal immune responses were measured by assaying IgA- and IgG-ASC in peripheral blood mononuclear cells (PBMCs). …”
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Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes by Leslie P. Cousens, Yan Su, Elizabeth McClaine, Xin Li, Frances Terry, Robert Smith, Jinhee Lee, William Martin, David W. Scott, Anne S. De Groot

“…HLA class II-restricted regulatory T cell (Treg) epitopes in IgG (also called “Tregitopes”) have been reported to suppress immune responses to coadministered antigens by stimulating the expansion of natural Tregs (nTregs). …”
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