Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b” by Angjelina Konini, Mingsong Kang, Seyed M. Moghadas

“…We sought to evaluate the immune responses to a bivalent Haemophilus influenzae glycoconjugate vaccine against serotypes “a” (Hia) and “b” (Hib) in the presence of the preexisting immunity to Hib. …”
Get full text

Immunotherapy of Cancer: Reprogramming Tumor-Immune Crosstalk by Kyle K. Payne, Amir A. Toor, Xiang-Yang Wang, Masoud H. Manjili

“…These include weak immunogenicity of the tumor, as well as immunosuppressive mechanisms which prevent effective antitumor immune responses. Recent studies suggest that aberrant expression of cancer testis antigens (CTAs) can generate robust antitumor immune responses, which implicates CTAs as potential targets for immunotherapy. …”
Get full text

The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

“…However, TPP can induce unwanted immune responses that can impact both drug efficacy and patient safety. …”
Get full text

Shedding new light on atherosclerosis therapeutics: Nanomedicines targeting atherosclerotic immune microenvironment by Zhiyue Wang, Jie Sheng, Guangming Lu, Longjiang Zhang

“…Moreover, we elaborated on nanomaterials that regulate innate immune responses, adaptive immune responses, and aberrant immunometabolism to achieve AIME modulation. …”
Get full text

Current Views of Toll-Like Receptor Signaling Pathways by Masahiro Yamamoto, Kiyoshi Takeda

“…Moreover, we will review the historical and current literature to describe the mechanisms behind TLR-mediated activation of innate immune responses.…”
Get full text

Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection by Ali Vural, John H. Kehrl

“…This review focuses on the intimately linked molecular mechanisms that help govern the autophagic pathway and macrophage innate immune responses.…”
Get full text

The effects of different dosage applications of Bacillus sp. NP5 para-probiotic on the growth performance and resistance of Nile tilapia against Streptococcus agalactiae infection by Widanarni, Sukenda, Annisa Astri Anggraeni, Rr. Bellya Anasti Maharani, Aldy Mulyadin, Munti Yuhana

“…NP5 through feed in improving the immune responses and resistance of tilapia juvenile (Oreochromis niloticus) to infection of Streptococcus agalactiae. …”
Get full text

Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis by Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu

“…Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. …”
Get full text

The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance by Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier

“…Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells. …”
Get full text

Human Schistosome Infection and Allergic Sensitisation by Nadine Rujeni, David W. Taylor, Francisca Mutapi

“…Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to allergic sensitisation. …”
Get full text

Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis by Pascal Lapierre, Alain Lamarre

“…An overly tolerant immune response can lead to chronic infections while an overreactive and unbridled immune response can lead to autoimmune hepatitis. …”
Get full text

Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells by Jonathan Kevin Sia, Maria Georgieva, Jyothi Rengarajan

“…Innate immune cells serve as barometers of the immune response against Mtb infection by determining the inflammatory milieu in the lungs and promoting the generation of adaptive immune responses. …”
Get full text

Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…Adjuvants are a diverse group of substances that can be added to vaccines to enhance antigen-specific immune responses and improve vaccine efficacy. The first adjuvants, discovered almost a century ago, were soluble crystals of aluminium salts. …”
Get full text

Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus by Lusine Khondkaryan, Sona Margaryan, David Poghosyan, Gayane Manukyan

“…High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. …”
Get full text

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy by Ji-Yoon Noh, Suk Ran Yoon, Tae-Don Kim, Inpyo Choi, Haiyoung Jung

“…Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses. They recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses by inducing inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules. …”
Get full text

The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis by Junchao Wu, Lisha Li, Tingrui Zhang, Jiaye Lu, Zongguang Tai, Quangang Zhu, Zhongjian Chen

“…Based on this analysis, the “lipid-microbiome” positive feedback loop, regulated by immune responses, is proposed. Key scientific concepts of review: The review delves into the impact of adaptive immune responses that regulate the EIME, driving AD, and investigates potential mechanisms by which lipid supplementation and probiotics may alleviate AD through the up-regulation of the epidermal barrier and modulation of immune signaling. …”
Get full text

Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Specific immune responses induced by the env mRNA vaccine were significantly stronger in the high-dose group than in the low-dose group. …”
Get full text

Impact of COVID-19 on Ocular Surface Health: Infection Mechanisms, Immune Modulation, and Inflammatory Responses by Duliurui Huang, Weixia Xuan, Zhijie Li

“…Additionally, the interplay between systemic and ocular immune responses is highlighted, analyzing how systemic COVID-19 inflammation influences ocular surface health. …”
Get full text

Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations... by Anthony Altieri, Grace V. Visser, Matthew B. Buechler

“…Fibroblasts can directly and indirectly regulate immune responses by secreting ECM and ECM-bound molecules to shape tissue structure and influence organ function. …”
Get full text

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling by Luca Genovese, Andrea Brendolan

“…Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. …”
Get full text