Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI by Victoria Kegel, Elisa Pfeiffer, Britta Burkhardt, Jia L. Liu, Katrin Zeilinger, Andreas K. Nüssler, Daniel Seehofer, Georg Damm

“…KC were able to detect hepatocyte stress/damage and to transmit a donor- and compound-dependent immune response via cytokine production.…”
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Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients by Figen Deveci, H. Handan Akbulut, Ilhami Celik, M. Hamdi Muz, Fulya İlhan

“…These cells could play important roles in the immune response to M tuberculosis infection.…”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…Since detrimental immune response is crucially responsible for the development and aggravation of DED, therapeutic agents which modulate phenotype and function of eye-infiltrated inflammatory immune cells could be used for the treatment of severe DED. …”
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Deciphering CSU pathogenesis: Network toxicologyand molecular dynamics of DOTP exposure by Fang Cao, Cui Guo, Jing Guo

“…GO and KEGG analyses were utilized to explore target functions, particularly in inflammation and immune response pathways. AutoDock was employed for molecular docking to predict DOTP's binding to core targets, followed by molecular dynamics simulations with Gromacs to observe detailed interactions and conformational changes in the target proteins. …”
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Bioinformatics Analysis of miRNAs Targeting TRAF5 in DLBCL Involving in NF-κB Signaling Pathway and Affecting the Apoptosis and Signal Transduction by Chunyao Li, Lanshan Huang, Yongqin Wen, Muhua Yi, Min Gao

“…DEGs were significantly concentrated in the NF-κB signaling pathway and cytokine-cytokine receptor interaction, and involved in the process of immune response and protein binding. MiR-15a-5p, miR-147a, miR-192-5p, miR-197-3p, miR-532-5p, and miR-650 were revealed to be targeting TRAF5 and participating in NF-κB signaling pathway and might impact the apoptosis and signal transduction of DLBCL. …”
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A unique case report on campylobacter rectus infection leading to acute motor axonal neuropathy in a pediatric patient by Uchechukwu Ibewuike, MBBS, John Kim, MD, Swati Mody, MBBS, Gregory Obala, MD, Ebere Ibezim, MBBS

“…Acute motor axonal neuropathy (AMAN), a subtype of Guillain-Barré Syndrome, arises from an atypical immune response, frequently initiated by infections caused by Campylobacter jejuni, although other infectious agents have also been identified. …”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…Target genes were detected by double-luciferase and pull down assays. qRT-PCR and Western blot were performed to analyze the expression of several important proteins involved in the immune response pathway, including coronin-1, interleukins (IL-10), forkhead transcription factor 1 (FOXO1), nucleotide-binding oligomerization domain protein (NOD) 1, NOD2, and receptor-interacting protein (RIP) 2. …”
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Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…Encouraging SBRT-PATHY-clinical outcomes, along with immunohistochemical and gene-expression analyses of surgically removed abscopal-tumor sites, suggested that delivery of the high-dose radiation to the partial tumor volume, with optimal timing based on the homeostatic fluctuation of the immune response and sparing the peritumoral immune-environment, would significantly enhance the immune-mediated anti-tumor effects.…”
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In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation by Matthew J. Hardwick, Ming-Kai Chen, Kwamena Baidoo, Martin G. Pomper, Tomás R. Guilarte

“…The ability to visualize the immune response with radioligands targeted to immune cells will enhance our understanding of cellular responses in inflammatory diseases. …”
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Transcriptional Profiling of Testis Development in Pre-Sexually-Mature Hezuo Pig by Zunqiang Yan, Qiaoli Yang, Pengfei Wang, Shuangbao Gun

“…Additionally, chemokine, B cell receptor, activation of immune response, and enzyme binding were enriched in macrophages. …”
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Detection and Role of Some Interleukins and Tumor Necrotic Factor Alpha among Patients with Tuberculosis by Wael Rasheed Obaead Alfatlawi, Marwa Kadhim Khudhair, Jwan Ahmed Ali

“…Conclusions: IL-2, IL-10, and IL-17 were significant components of the immune response to TB; their distinct profiles, obtained from easily accessible kits, might be used to diagnose TB cases. …”
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Role of High-Density Lipoprotein Cholesterol (HDL-C) as a Clinical Predictor of Decompensation in Patients with Chronic Liver Disease (CLD) by Harshavardhan Rao B, Priya Nair, Anoop K. Koshy, S. Krishnapriya, C. R. Greeshma, Rama P. Venu

“…High-density lipoprotein cholesterol (HDL-C) has a significant role in innate immune response to LPS in the circulation and could therefore increase the risk for decompensation in patients with CLD. …”
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Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer by Qin Fang, Shuru Chen, Xiaoyue Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu

“…BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly understood. …”
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Screening key genes for intracranial aneurysm rupture using LASSO regression and the SVM-RFE algorithm by Qi Wu, Chunli Yang, Cuilan Huang, Zhiying Lin

“…Further functional analysis suggested that the DEGs were enriched in inflammation and immune response pathways. Fourteen hub genes were identified using the two algorithms. …”
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Chelate compounds and their use for correction of trace element deficiencies in livestock (review) by A. G. Koshchaev, N. E. Gorkovenko, A. V. Kosykh, D. V. Antipova

“…Due to the immunostimulatory activity resulting from increase in the content of sialic acids, properdin, ceruloplasmin, gamma globulin protein fraction, the metal chelates (copper, cobalt, iodine) can be used as immune response modulators. Iron chelate compounds are used for therapy and prevention of iron deficiency anemias not only in veterinary, but also in human medicine. …”
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Why Does Pnemococcus Kill? by Yves Bergeron, Michel G Bergeron

“…While many virulence factors have been associated with fatal pneumococcal pneumonia. there is growing evidence that some components of the immune response contribute significantly to the high mortality rate. …”
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Systemic immune-inflammation index and the short-term mortality of patients with sepsis: A meta-analysis by Lingbo Liang, Qiaoli Su

“… The systemic immune-inflammation index (SII) is a novel biomarker that reflects the balance between the host immune response and inflammation, two key pathophysiological processes involved in sepsis. …”
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A Review on the Role of Human Solute Carriers Transporters in Cancer by Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das

“…Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response. Conclusion The review recognized the crucial role of SLC transporters in different types of cancer progression. …”
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Electrochemically reduced graphene oxide integrated with carboxylated-8-carboxamidoquinoline: A platform for highly sensitive voltammetric detection of Zn(II) ion by screen-printed... by Ling Ling Tan, Nur Syamimi Mohamad, Nurul Izzaty Hassan, Choo Ta Goh

“…Zinc has been demonstrated to boost immune response during SAR-CoV-2 infection, where it prevents coronavirus multiplication. …”
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The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses. by Smita Gopinath, Andrew Hotson, Jennifer Johns, Garry Nolan, Denise Monack

“…Taken together, we demonstrate a novel role for neutrophils in blunting IL-2-mediated proliferation of the TH1 immune response in the spleens of mice that are colonized by high levels of S. …”
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