Humoral and Cellular Immunity After Vaccination Against SARS-CoV-2 in Relapsing-Remitting Multiple Sclerosis Patients Treated with Interferon Beta and Dimethyl Fumarate by Marcin Bazylewicz, Monika Zajkowska, Monika Gudowska-Sawczuk, Rafał Kułakowski, Jan Mroczko, Dagmara Mirowska-Guzel, Joanna Kulikowska-Łoś, Agata Czarnowska, Barbara Mroczko, Jan Kochanowicz, Alina Kułakowska

“…Therefore, the aim of our study was to evaluate the humoral and cellular immune response in PwMS treated with DMTs. Methods: The concentrations of IgG Spike (S) anti-SARS-CoV-2 antibodies and IgG Nucleocapsid (N) anti-SARS-CoV-2 antibodies, as well as interferon-gamma <i>(IFN-</i>γ) titers were analyzed in PwMS groups treated with dimethyl fumarate (DMF), interferon beta (IFN), and healthy control group. …”
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MsCL-P1: A multifunctional C-type lectin from largemouth bass (Micropterus salmoides) with broad microbe binding and agglutination activities by Siyi She, Ying Ye, Fengyao Guo, Shun Yang, Mengmeng Huang, Hui Fei

“…These results suggest that MsCL-P1 plays a multifaceted role in the innate immune response of largemouth bass, potentially through recognition of PAMPs, agglutination of microbes, and direct inhibition of microbial growth. …”
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Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer by Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker

“…Hemocyanins, as opposed to QS-21, had no cytotoxic effect on either oral cancer cell line cultured in vitro, supporting the idea that the antitumor effects of hemocyanins are associated with their modulation of the immune response. Therefore, hemocyanin utilization would allow a lower QS-21 dosage to achieve therapeutic results. …”
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Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk by Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

“…Functional enrichment analyses of DMGs revealed significant involvement in biological processes such as transcription regulation, signal transduction, and immune response, highlighting the potential mechanistic pathways of these biomarkers. …”
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Dietary addition of compound organic acids improves the growth performance, carcass trait, and body health of broilers by Fang Cai, Meiping Huang, Wei Liu, Xiaoling Wan, Kai Qiu, Xiao Xu

“…Despite their promising effects in other animal species, the impact of this novel compound organic acidifier on broiler performance, metabolism, and immune response has not been fully elucidated. This study aims to evaluate the effects of this compound acidifier on growth performance, serum lipid profile, antioxidant status, and immune parameters in broilers, providing insights into its potential benefits as a dietary supplement for broiler health and productivity.MethodsA total of 240 broilers were randomly divided into four groups: a control group and three treatment groups receiving 0.25%, 0.5%, or 1.0% acidifier, with six replicates of ten birds each. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechanisms of action, to ensure sufficient and sustained effects, and to document these. …”
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Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis by Yirong Ma, Shuguang Wu, Junyu Lai, Qiang Wan, Jingxuan Hu, Yanhong Liu, Ziyi Zhou, Jianguang Wu

“…This study proposes that an aberrant immune response might represent a shared pathogenic mechanism in AS and HT. …”
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The application of pigment-protein fraction from Nannochloropsis oculata on β-actin response of Cromileptes altivelis infected with viral nervous necrosis by Uun Yanuhar, Achmad Khumaidi

“…An outcome from gene transcription, the protein protects against pathogen infection, such as receptor clustering, antigen internalization, and regulating vesicle for antigen processing. ß - actin expression will determine the success of immune response of the organism. This study aimed to understand the role of pigment-protein fraction (PPF) from Nannochloropsis oculata in the increase of β-actin expression in humpback grouper Cromileptes altivelis infected by viral nervous necrosis (VNN). …”
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response by Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

“…Abstract The zinc finger protein 32 (ZNF32) has been associated with high expression in various cancers, underscoring its significant function in both cancer biology and immune response. To further elucidate the biological role of ZNF32 and identify potential immunotherapy targets in cancer, we conducted an in-depth analysis of ZNF32. …”
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First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies by Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag

“…Secondary objectives included determination of the pharmacokinetics, immunogenicity and clinical efficacy assessed with CT scans using immune Response Evaluation Criteria in Solid Tumors. Exploratory objectives included pharmacodynamic (PD) assessment of immune system biomarkers.Results Of the 27 patients screened, 25 received treatment with ATOR-1017. …”
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Multi-omics analysis reveals interactions between host and microbes in Bama miniature pigs during weaning by Wen Ma, Li Yin, Ying Hu, Xu Liu, Zhenghong Guo, Bingyang Zhong, Haofeng Qiu, Jing Li

“…The upregulated genes after weaning were enriched in immune response categories, whereas downregulated genes were enriched in protein degradation. …”
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Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis by Lei Wan, Jian Liu, Chuanbing Huang, Ziheng Zhu, Kun Wang, Guanghan Sun, Lei Zhu, Zhongxiang Hu

“…Differentially expressed m6A genes were correlated with macrophage activation involved in immune response, vascular endothelium, MAPK signaling pathway, PI3K − Akt signaling pathway, and other inflammatory processes. …”
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Prevalidation of an ELISA for Detection of a New Clinical Entity: Leishmania donovani-Induced Cutaneous Leishmaniasis by Bhagya Deepachandi, Sudath Weerasinghe, Himali Gunathilake, Thisira P. Andrahennadi, Mahendra N. Wickramanayake, Shantha Siri, Vishvanath Chandrasekharan, Preethi Soysa, Yamuna Siriwardana

“…Although CL is generally not considered to evoke a humoral immune response except for a nonrobust and a variable response in minority of cases, VL is associated with a clear strong humoral response. …”
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Comparison of various feed additives on nutrient digestibility, digestive enzyme activity, blood metabolite levels, and gut microbiota composition in japanese quail chicks by Hassan Saleh, Omid Jangjou, Mohammad Taher Mirakzehi, Seyedeh Hamideh Hosseni

“…Conclusion: The inclusion of iron oxide nanoparticles and fumaric acid supplementation in the diet of quail chicks has been found to enhance their growth, nutrient digestibility, immune response, antioxidant status, digestive enzymes, and intestinal health. …”
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Cognitive impairment, depressive and anxiety disorders among post-COVID-19 survivors: a follow-up study by Ayman A. Aziz, Ahmed A. Latif, Sandra W. Elseesy

“…Abstract Background Psychiatric signs may be induced by the cytokine storm that is implicated in the immune response to coronavirus through neuro-inflammation. …”
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Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…FcγRs are distinguished by their affinity for the Fc fragment, cell distribution, and type of immune response they induce. Activating FcγRIIIa (CD16A) on natural killer cells plays a crucial role in mediating ADCC, and activating FcγRIIa (CD32A) and FcγRIIIa on macrophages are important for mediating ADCP. …”
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Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis by Najeeha Talat Iqbal, Hana Khan, Aqsa Khalid, Syed Faisal Mahmood, Nosheen Nasir, Iffat Khanum, Isadora de Siqueira, Wes Van Voorhis

“…Long COVID appears to be accompanied by an auto-immune multi-faceted syndrome where the virus or viral antigen persistence causes continuous stimulation of the immune response, resulting in multi-organ immune dysregulation. …”
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Exploring the Pathophysiology, Diagnosis, and Treatment Options of Multiple Sclerosis by Simone Lorenzut, Ilaria Del Negro, Giada Pauletto, Lorenzo Verriello, Leopoldo Spadea, Carlo Salati, Mutali Musa, Caterina Gagliano, Marco Zeppieri

“…To stop relapses and reduce the course of the disease, disease-modifying treatments (DMTs) target several components of the immune response. DMTs that are now on the market include interferons, glatiramer acetate, monoclonal antibodies, and oral immunomodulators; each has a unique mode of action and safety profile. …”
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Sex-specific alterations in creatine metabolism in cellular compartments of peripheral blood leukocytes in type 1 diabetes by Nina Alchujyan, Elena Aghajanova, Nina Movsesyan, Arthur Melkonyan, Artashes Guevorkian, Armen Andreasyan, Margarita Hovhannisyan

“…The creatine (Cr)/creatine kinase (CK) system plays a crucial role in cellular energy metabolism, glucose control, and the immune response. This study aimed to investigate this system in the peripheral blood leukocytes (PBL) of Armenians with type 1 diabetes (T1D) who received insulin therapy. …”
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Fortifying plant fortresses: siderophores in defense against Cercospora leaf spot disease in Vigna radiata L. by Anushree Kamath, Abhishek Sharma, Arpit Shukla, Arpit Shukla, Arpit Shukla, Paritosh Parmar, Dhara Patel

“…Total phenolic content was highest in SP15 (100 µg/mL), showing a a ramified immune response whereas S15 recorded 80 µg/mL, significantly above the control. …”
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