Neutrophil Reverse Migration Becomes Transparent with Zebrafish by Taylor W. Starnes, Anna Huttenlocher

“…Still, the mechanisms underlying neutrophil reverse migration and its effects on the resolution or priming of immune responses remain unclear. Here, we review the current knowledge of neutrophil reverse migration, its potential roles in host immunity, and the live imaging tools that make zebrafish a valuable model for increasing our knowledge of neutrophil behavior in vivo.…”
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New Immunotherapeutic Approaches for Glioblastoma by Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz

“…The heterogeneity of GBM makes this tumor difficult to treat, and the immunotherapies result in an attractive approach to modulate the antitumoral immune responses favoring the tumor eradication. The immunotherapies for GMB including monoclonal antibodies, checkpoint inhibitors, vaccines, and oncolytic viruses, among others, have shown favorable results alone or as a multimodal treatment. …”
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Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead by Alma Zernecke

“…Dendritic cells (DCs) and T cells are present within atherosclerotic lesions and function as central players in the initiation and modulation of adaptive immune responses. In previous years, we have studied the functional contribution of distinct DC subsets in disease development, namely, that of CCL17-expressing DCs as well as that of plasmacytoid DCs that play specialized roles in disease development. …”
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Immunological Perspective: Helicobacter pylori Infection and Gastritis by Hang Yang, Bing Hu

“…It can achieve persistent colonization by manipulating the host immune responses, which also causes mucosal damage and inflammation. …”
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An overview of the human immune system and the role of interferon regulatory factors (IRFs) by Ashwinder Kaur, Chee-Mun Fang

“…To deploy effective immune responses, immune systems comprise various cells and molecules that communicate with each other via signaling pathways coordinated by gene regulatory networks. …”
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Prebiotic emergent sources for aquaculture: Microalgae and insects by Mónica Vanessa Oviedo-Olvera, Ana Angélica Feregrino-Pérez, María Isabel Nieto-Ramírez, Marta Montserrat Tovar-Ramírez, Humberto Aguirre-Becerra, Juan Fernando García-Trejo

“…Functional food development for fish nourishment includes ingredients containing bioactive compounds, such as prebiotics, that generate favorable immune responses. Non-digestible oligosaccharides function as growth promoters of the intestinal microbiota, improving nutrient absorption and enhancing the fish immune system. …”
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Peroxisome Proliferator-Activated Receptors and Acute Lung Injury by Rosanna Di Paola, Salvatore Cuzzocrea

“…Recently, PPARs and their respective ligands have been implicated as regulators of cellular inflammatory and immune responses. These molecules are thought to exert anti-inflammatory effects by negatively regulating the expression of proinflammatory genes. …”
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Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment by Fabian Flores-Borja, Sheeba Irshad, Peter Gordon, Felix Wong, Ibrahim Sheriff, Andrew Tutt, Tony Ng

“…Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions between innate and adaptive immune cells in a variety of immune responses in infection, allergy, and autoimmunity. …”
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Microbiota modifications in prehabilitation – the next step towards comprehensive preparation for surgery. The scoping review by Igor Łoniewski, Tomasz Banasiewicz, Jerzy Sieńko, Karolina Skonieczna-Zydecka, Ewa Stachowska

“…Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery. The review advocates for an individualised approach to prehabilitation, incorporating microbiota modifications based on patient-specific factors and surgery type. …”
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Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges by Yangjie Gao, Zhe Ji, Jingyu Zhao, Julin Gu

“…In this study, the therapeutic potential of MSCs for FIs was reviewed, including their roles played by secreting antimicrobial peptides, regulating immune responses, and promoting tissue repair. Meanwhile, the status of research on MSCs in FIs and the controversies were also discussed. …”
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Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance by Inès Dufait, Therese Liechtenstein, Alessio Lanna, Christopher Bricogne, Roberta Laranga, Antonella Padella, Karine Breckpot, David Escors

“…Recently retroviral and lentiviral vectors have been used to generate tolerogenic dendritic cells, key professional antigen presenting cells that regulate immune responses. Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology. …”
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Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy by George Chigozie Njoku, Cathal Patrick Forkan, Fumie Mitani Soltysik, Peter Lindberg Nejsum, Flemming Pociot, Reza Yarani

“…EVs are nano-sized vesicles that are non-replicating and carry bioactive molecules that modulate immune responses, promote tissue repair, can facilitate drug delivery and, therefore, hold great therapeutic promise. …”
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Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection by Louise E. Pilsbury, Rachel L. Allen, Martin Vordermeier

“…Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression and function. …”
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Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity by Amanda H. Lee, Daphne Michelle Rodriguez Jimenez, Marlies Meisel

“…This review delves into the role of L. reuteri in modulating immune responses, with a focus on its impact on systemic diseases.…”
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Current understanding of immune-like responses in worms by Abdul Qadeer, Guofeng Cheng

“…Investigating the immune responses in invertebrates is essential, as they may contribute to unique mechanisms for biological diversity. …”
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Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

“…This review highlights noninvasive biomarkers that predict, diagnose, and assess transplant prognosis by reflecting graft injury, inflammation, and immune responses. For example, donor-derived cell-free DNA (dd-cfDNA) is highly sensitive in detecting early graft injury, whereas gene expression profiling effectively excludes moderate-to-severe acute rejection (AR). …”
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin... by Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani

“…From the transcriptome analysis in PBMCs, this multivariate model was significantly correlated with the gene signatures related to immune responses, such as CD8 T-cell activation/proliferation and proinflammatory immune responses, and 12 amino acid-related genes were differentially expressed between the high-risk and low-risk groups.Conclusions The multivariate model with PFAAs and metabolites in plasma might be useful for stratifying patients who will benefit from PD-1 inhibitors.…”
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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a... by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

“…Summary: Background: mRNA-based cancer vaccines show promise in triggering antitumour immune responses. To combine them with existing immunotherapies, the intratumoral immune microenvironment needs to be deeply characterised. …”
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Evaluation of the Expression of Infection-Related Long Noncoding RNAs among COVID-19 Patients: A Case-Control Study by Zahra Firoozi, Elham Mohammadisoleimani, Farzaneh Bagheri, Atefeh Taheri, Babak Pezeshki, Mohammad Mehdi Naghizadeh, Abdolreza Daraei, Jalal Karimi, Yousef Gholampour, Yaser Mansoori, Zahra Montaseri

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a worldwide pandemic, activates signaling cascades and leads to innate immune responses and secretion of multiple chemokines and cytokines. …”
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An update on the ocular manifestations of dengue by Christina Wang, Arturo Castillo, Federico Cortes-Bejarano, Eduardo Lopez, Eduardo Cunha de Souza, Lihteh Wu

“…The precise pathophysiologic mechanisms involved in dengue infection involve a complex interplay between host immune responses, virus, and host genes. There is no specific treatment for ocular dengue. …”
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