Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era? by Prasan Deep Rath, Swetal Pandey, Rahul Bisaralli

“…Another mechanism is the neural inflammatory reflex that regulates innate and adaptive immune responses and also inhibits the production of a vital inflammatory therapeutic target molecule, known as tumor necrosis factor, for RA. …”
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Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,... by Malabi M Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar

“…Previously, mucosal immune responses were measured by assaying IgA- and IgG-ASC in peripheral blood mononuclear cells (PBMCs). …”
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Effects of Escherichia coli Nissle 1917 on immunity, blood constituents, antioxidant capacity, egg quality and performance in laying Japanese quail by Asghar Sedaghat, Mohammad Amir Karimi Torshizi, Mohammad Reza Soleimani

“…This study was conducted to evaluate the effects of E.coli Nissle 1917 (EcN) on immune responses, blood parameters, oxidative stress, egg quality, and performance of laying Japanese quail. …”
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Cytokine Immunopathogenesis of Enterovirus 71 Brain Stem Encephalitis by Shih-Min Wang, Huan-Yao Lei, Ching-Chuan Liu

“…EV71 replicates in leukocytes, endothelial cells, and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. …”
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Vaccine adjuvants for immunotherapy: type, mechanisms and clinical applications by Nimeet Desai, Sherrin Gotru, Sagar Salave, Lalitkumar K. Vora

“…These emerging agents hold promise for enhancing immune responses while tailoring therapies to specific disease contexts, from cancer to infectious diseases. …”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Hypofractionation or other modifications of standard fractionation may improve radiation’s ability to promote immune responses to tumors. Other novel delivery options may also affect immune responses, including T-cell activation and tumor-antigen presentation changes. …”
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cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

“…The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. …”
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T Helper 17 Cells in Autoimmune Liver Diseases by Masanori Abe, Yoichi Hiasa, Morikazu Onji

“…In contrast, another distinct subset of T cells, regulatory T cells (Treg), downregulate immune responses and play an important role in maintaining self-tolerance. …”
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NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance by Shaoyan Shi, Xuehai Ou, Chao Liu, Rui Li, Qianjin Zheng, Leiming Hu

“…Osteosarcoma, a highly aggressive malignancy with a generally poor prognosis, is characterized by tumor cells’ ability to evade immune responses and resist treatment. The nuclear transcription factor NF-κB signaling pathway is crucial in regulating inflammatory and immune reactions. …”
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery by Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton

“…These birds produce robust immune responses, consisting of antigen-specific antibodies targeting diverse epitopes with a range of affinities. …”
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A subunit vaccine Ag85A-LpqH focusing on humoral immunity provides substantial protection against tuberculosis in mice by Lingyuan Zeng, You Zuo, Minghui Tang, Chengrui Lei, Huoming Li, Xiuling Ma, Jiahong Ji, Hao Li

“…This vaccine can induce robust antibody responses, as well as T cell immune responses especially strong CD8+ T cell responses. …”
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The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review by Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G

“…It explores the mechanisms by which TCM augments immune responses, particularly focusing on how these formulations influence both innate and adaptive immunity. …”
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Effect of gut microbiota changes on cytokines IL-10 and IL-17 levels in liver transplantation patients by Mohamed Abdel-Raoof Fouda, Mohamed Abdel-Wahhab, Ahmed Esmail Abdelkader, Mohsen El-Sayd Ibrahim, Taher Abozeid Elsheikh, Hisham Mohammad Aldeweik, Nora Elfeky

“…Cytokines, small signaling molecules, significantly influence immune responses during and post-liver transplantation. …”
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Vibrio Dynamics and Health Status of Pacific White Shrimp Fed with Cinnamaldehyde-Containing Feed by Dian Eka Ramadhani, Andri Hendriana, Dinamella Wahjuningrum, Muhammad Arif Mulya

“…The decrease of green Vibrio bacteria and increased colonization of yellow Vibrio bacteria were correlated with immune responses. The best treatment in this study is treatment C.…”
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Characterization of <i>Streptococcus pyogenes</i> Strains from Tonsillopharyngitis and Scarlet Fever Resurgence, 2023—FIRST Detection of M1_UK in Bulgaria by Emma Keuleyan, Theodor Todorov, Deyan Donchev, Ani Kevorkyan, Radoslava Vazharova, Alexander Kukov, Georgi Todorov, Boriana Georgieva, Iskra Altankova, Yordanka Uzunova

“…A mixed pattern of pro- and anti-inflammatory immune responses in patients was observed.…”
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Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma by Yuchen Zhang, Junnian Zheng, Li Sun, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Renjin Chen, Dafei Chai, Jiawei Wang, Zichun Zhang, Xiaohui Xie

“…Immunization with Ad-Siglec-E/CAIX promoted the induction and maturation of CD11c+ dendritic cells and their subsets, which in turn enhanced tumor-specific CD8+ T cell immune responses, as evidenced by increased CD8+ T cell proliferation and CTL activity. …”
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SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases by Minoru Fujimoto, Tetsuji Naka

“…Toll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are involved in the regulation of TLR-mediated immune responses. …”
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Influence of Epinastine Hydrochloride, an H1-Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo by Ken-Zaburo Oshima, Kazuhito Asano, Ken-Ichi Kanai, Miyuki Suzuki, Harumi Suzaki

“…There is established concept that dendritic cells (DCs) play essential roles in the development of allergic immune responses. However, the influence of H1 receptor antagonists on DC functions is not well defined. …”
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From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis by Sara Ahmadi Badi, Samira Tarashi, Abolfazl Fateh, Pejman Rohani, Andrea Masotti, Seyed Davar Siadat

“…It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” …”
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Beyond Needles: Immunomodulatory Hydrogel-Guided Vaccine Delivery Systems by Md Mohosin Rana, Cigdem Demirkaya, Hector De la Hoz Siegler

“…Additionally, this review addresses critical challenges, including safety, scalability, and regulatory considerations, offering insights into hydrogel-guided strategies for eliciting targeted immune responses and advancing global immunization efforts.…”
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