A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…Furthermore, both in anti-PD-1-responsive and -resistant tumor models, the Pep-TACs exert significant anti-tumor immune response. It is noteworthy that Pep-TACs can cross the BBB and prolong the survival of mice with in situ brain tumor. …”
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SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer by Qingyu Huang, Wenhui Yang, Fuhao Wang, Rui Huang, Qian Wang, Xiaohui Li, Tianyu Lei, Shengqin Yue, Wenxue Zou, Qi An, Jinbo Yue, Qinyong Hu, Chao Liu

“…However, our prior study identified SELP expression in a specific subpopulation of endothelial cells within cervical cancer (CC) and potentially linked to anti-cancer immune response. The precise mechanisms by which SELP influences anti-cancer immunity and its involvement in radiotherapy response in CC, however, remain elusive. …”
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Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis by Charlene Hawkins, Guzel Shaginurova, D. Auriel Shelton, Jose D. Herazo-Maya, Kyra A. Oswald-Richter, Joseph E. Rotsinger, Anjuli Young, Lindsay J. Celada, Naftali Kaminski, Carla Sevin, Wonder P. Drake

“…Investigation of the Th1 immune response in sarcoidosis CD4+ T cells has revealed reduced proliferative capacity and cytokine expression upon TCR stimulation. …”
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Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45 by Michael Pritsch, Najib Ben-Khaled, Michael Chaloupka, Sebastian Kobold, Nicole Berens-Riha, Annabell Peter, Gabriele Liegl, Sören Schubert, Michael Hoelscher, Thomas Löscher, Andreas Wieser

“…Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. …”
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Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works by Wangcai Ren, Jialing Wen, Gang Guo, Gang Guo, Wenchao Gu, Shenke Zhang, Shenke Zhang, Chang Liu, Chang Liu, Kensuke Osada, Takashi Shimokawa, Qiaojuan Wang, Qiaojuan Wang, Yue Wang, Yue Wang, Xuanzhang Tu, Chen Li, Li Sui, Liqiu Ma, Liqiu Ma, Liqiu Ma

“…Differences between patients with respect to physical factors and intrinsic biological factors that activate the immune response (acquired factors) may affect the induction of the abscopal effect.…”
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Inflammatory Monocyte Subsets Correlation with Iron Levels in Low Vitamin D Pediatric Transfusion-Dependent Thalassemia by Ghozali M, Matahari M, Cahyadi AI, Agustini SD, Ghrahani R, Reniarti L, Setiabudiawan B, Panigoro R

“…Mohammad Ghozali,1 Matahari Matahari,2 Adi Imam Cahyadi,1 Sri Devi Agustini,2 Reni Ghrahani,3 Lelani Reniarti,3 Budi Setiabudiawan,3 Ramdan Panigoro1 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 45363, Indonesia; 2Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 45363, Indonesia; 3Department of Pediatrics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 40161, IndonesiaCorrespondence: Mohammad Ghozali, Email moh.ghozali@unpad.ac.idBackground: Patients with transfusion-dependent thalassemia experience iron dysregulation, which affects the immune response. Surface proteins such as FcγRIII (CD16), lipopolysaccharide receptor (CD14), and human leukocyte antigen (HLA-DR) on monocytes are crucial for innate and adaptive responses. …”
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Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection by Vicente P. Martins, Carina S. Pinheiro, Barbara C. P. Figueiredo, Natan R. G. Assis, Suellen B. Morais, Marcelo V. Caliari, Vasco Azevedo, William Castro-Borges, R. Alan Wilson, Sergio C. Oliveira

“…Immunization of mice with GPI-anchored proteins induced a mixed Th1/Th2 type of immune response with production of IFN-γ and TNF-α, and low levels of IL-5 into the supernatant of splenocyte cultures. …”
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response by Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

“…Abstract The zinc finger protein 32 (ZNF32) has been associated with high expression in various cancers, underscoring its significant function in both cancer biology and immune response. To further elucidate the biological role of ZNF32 and identify potential immunotherapy targets in cancer, we conducted an in-depth analysis of ZNF32. …”
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New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness by Giuseppe Spaziano, Donato Cappetta, Konrad Urbanek, Elena Piegari, Grazia Esposito, Maria Matteis, Manuela Sgambato, Gioia Tartaglione, Rosa Russo, Raffaele De Palma, Francesco Rossi, Antonella De Angelis, Bruno D’Agostino

“…These data, together with the increased apoptosis of inflammatory cells in vivo, indicate that c-kit+ cells downregulate immune response in asthma by influencing local environment, possibly by cell-to-cell contact combined to paracrine action. …”
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Lactoferrin Decreases the Intestinal Inflammation Triggered by a Soybean Meal-Based Diet in Zebrafish by Pilar E. Ulloa, Camila J. Solís, Javiera F. De la Paz, Trevor G. S. Alaurent, Mario Caruffo, Adrián J. Hernández, Patricio Dantagnan, Carmen G. Feijóo

“…To determine the influence of intestinal inflammation on the general immune response, larvae were challenged with Edwardsiella tarda. …”
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Oncolytic Viruses and Immunotherapy for the Treatment of Uveal Melanoma and Retinoblastoma: The Current Landscape and Novel Advances by Merve Kulbay, Nicolas Tuli, Massimo Mazza, Armaan Jaffer, Sarinee Juntipwong, Emily Marcotte, Stuti Misty Tanya, Anne Xuan-Lan Nguyen, Miguel N. Burnier, Hakan Demirci

“…These anti-cancer treatment options provide numerous advantages such as selective cancer cell death and the promotion of an anti-tumor immune response, and they prove useful in preventing vision impairment due to macular and/or optic disc involvement. …”
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Dietary supplementation with sodium humate improves egg quality and immune function of laying hens by A.R. Zhang, S.A. Pirzado, G.H. Liu, Z.M. Chen, W.H. Chang, H.Y. Cai, W.L. Bryden, A.J. Zheng

“…The aim of this study was to evaluate the influence of the dietary addition of sodium humate (HAS) on performance and immune response of laying hens during peak lay, over an eight-week period. …”
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First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies by Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag

“…Secondary objectives included determination of the pharmacokinetics, immunogenicity and clinical efficacy assessed with CT scans using immune Response Evaluation Criteria in Solid Tumors. Exploratory objectives included pharmacodynamic (PD) assessment of immune system biomarkers.Results Of the 27 patients screened, 25 received treatment with ATOR-1017. …”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…The combination therapy stimulated the immune response and altered the tumour microenvironment, warranting further exploration in the future.…”
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Multi-omics analysis reveals interactions between host and microbes in Bama miniature pigs during weaning by Wen Ma, Li Yin, Ying Hu, Xu Liu, Zhenghong Guo, Bingyang Zhong, Haofeng Qiu, Jing Li

“…The upregulated genes after weaning were enriched in immune response categories, whereas downregulated genes were enriched in protein degradation. …”
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Virus-inspired biogenic delivery system for advancing cancer therapy by Di Sun, Hao Liang, Qianwen Mu, Chengchao Chu, Gang Liu, Chao Liu

“…In vaccine research, Virus-mimic nanovesicles have been effectively verified against cancer via the immunogenicity and the pharmacological effect of drug molecules delivered to mediate an immune response in the body. This review summarizes the research status of virus-inspired drug delivery platforms for cancer therapy utilization.…”
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Acceptance commitment therapy (ACT) for psychological distress associated with inflammatory bowel disease (IBD): protocol for a feasibility trial of the ACTforIBD programme by Richard Gearry, Matthew Fuller-Tyszkiewicz, Andrew McCombie, Peter Gibson, Simon Knowles, Lisa Olive, Antonina Mikocka-Walus, Subhadra Evans, Leanne Raven, Daniel Romano, Eric O, Madeleine Dober, Leesa van Niekerk, Susan Chesterman

“…Introduction Inflammatory bowel disease (IBD) involves an abnormal immune response to healthy gut bacteria. When a person develops IBD, their susceptibility to anxiety and/or depression increases. …”
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Designing a broad-spectrum multi-epitope subunit vaccine against leptospirosis using immunoinformatics and structural approaches by Guneswar Sethi, Guneswar Sethi, Young Kyu Kim, Su-Cheol Han, Jeong Ho Hwang, Jeong Ho Hwang

“…Immune simulations and in silico cloning were also conducted to evaluate the vaccine’s immune response and expression potential.ResultsThe MESV demonstrated high antigenicity, immunogenicity, non-allergenicity, and conservation across different Leptospira strains. …”
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Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis by Lei Wan, Jian Liu, Chuanbing Huang, Ziheng Zhu, Kun Wang, Guanghan Sun, Lei Zhu, Zhongxiang Hu

“…Differentially expressed m6A genes were correlated with macrophage activation involved in immune response, vascular endothelium, MAPK signaling pathway, PI3K − Akt signaling pathway, and other inflammatory processes. …”
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Prevalidation of an ELISA for Detection of a New Clinical Entity: Leishmania donovani-Induced Cutaneous Leishmaniasis by Bhagya Deepachandi, Sudath Weerasinghe, Himali Gunathilake, Thisira P. Andrahennadi, Mahendra N. Wickramanayake, Shantha Siri, Vishvanath Chandrasekharan, Preethi Soysa, Yamuna Siriwardana

“…Although CL is generally not considered to evoke a humoral immune response except for a nonrobust and a variable response in minority of cases, VL is associated with a clear strong humoral response. …”
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