Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy by Changyong Guo, Fei Gao, Guoyuan Wu, Jinqiu Li, Chunquan Sheng, Shipeng He, Honggang Hu

“…The Pha‐PLG molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, and activating CD8+ T cells, thus promoting a robust anti‐tumor immune response. In vivo, studies confirm superior biosafety, tumor targeting, and HER2 degradation, with increased cytotoxic T cell activity and improved antitumor immunity. …”
Get full text

Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…It allows for the differentiation between asymptomatic and symptomatic individuals and sheds light on the immune response mechanisms that contribute to disease progression. …”
Get full text

Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice by Shijia Le, Fengyiyang Xu, Zhi Luo, Weihao Shi, Shuangshuang Lu, Zengyu Zhang, Zimin Guo, Wenshi Xu, Mingqi Yang, Tianyi Li, Xu Li, Kun Liang, Lei Zhu

“…Additionally, PU.1 plays a critical role in mediating immune responses, offering a potential target for therapeutic intervention.…”
Get full text

Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest by Anton Amann, Bernhard Widner, Josef Rieder, Herwig Antretter, Georg Hoffmann, Viktoria Mayr, Hans-Ulrich Strohmenger, Dietmar Fuchs

“…Therefore, monitoring of neopterin concentrations and of tryptophan degradation can serve to detect the extent of T helper cell 1-type immune activation during cellular immune response in humans. In a porcine model of cardiac arrest, we examined the potential use of neopterin measurements and determination of the tryptophan degradation rate as a means of estimating the extent of immune activation. …”
Get full text

ZEB1 as a marker of metastasis in thyroid carcinomas: review of literature and own data by P.P. Zinych, V.M. Pushkarev, N.I. Levchuk, M. Tronko

“…ZEB1 is at the forefront of transcription factors involved in the EMT control and promotes tumor cell migration and diffusion, cell stemness, resistance to treatment, metastasizing and evasion of the immune response. Since ZEB1 is a key regulator of EMT, metastasizing is associated with cancer stem cell formation and resistance to therapy in many cancers, including papillary thyroid carcinoma. …”
Get full text

Effect of Fusion to the LTB Carrier Protein on Coronavirus Spike Protein Vaccine Candidates Produced in Maize by Erin Egelkrout, Magdalena Maj, Rodrigo Manjarin, Gina Fake, Muneaki Watanabe, Jenna Williams, Nate Blanchard, John Walker, Celine Hayden, John Howard

“…In this study, we (1) test orally delivered PEDV vaccine candidates in pigs to optimize the mucosal immune response; (2) generate the SARS-CoV-2 S1 protein in maize; and (3) perform structural characterization of the S1 protein for PEDV and SARS-CoV-2. …”
Get full text

Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…Pestiviruses generally counteract the cellular innate immune response by degradation of interferon regulatory factor 3 (IRF3) mediated by the viral N-terminal protease (N^pro). …”
Get full text

Studying the Humoral Response against SARS-CoV-2 in Cuban COVID-19 Recovered Patients by Ivette Orosa Vázquez, Marianniz Díaz, Yaima Zúñiga Rosales, Klayris Amada, Janoi Chang, Ernesto Relova Hernández, Yaima Tundidor, Hilda Roblejo Balbuena, Giselle Monzón, Bárbara Torres Rives, Enrique Noa Romero, Danay Carrillo Valdés, Irinia Valdivia Álvarez, Aurora Delahanty Fernández, Claudia Díaz, Joaquín Solozabal, Mileidys Gil, Belinda Sánchez, Gertrudis Rojas, Beatriz Marcheco, Tania Carmenate

“…Understanding the immune response generated by SARS-CoV-2 is critical for assessing efficient therapeutic protocols and gaining insights into the durability of protective immunity. …”
Get full text

The Underlying Molecular Basis and Mechanisms of Venous Thrombosis in Patients with Osteomyelitis: A Data-Driven Analysis by Peisheng Chen, Yinhuan Liu, Xiaofeng Lin, Bin Yu, Bin Chen, Fengfei Lin

“…GO-BP terms of OMGs1 and shared DGEs1 were mainly enriched in the neutrophil-related immune response process, and the shared GO-BP terms of OMGs1 and VTEGs1 seemed to be focused on cell activation, immune, defense, and inflammatory response to stress or biotic stimulus. 230 VTEGs2, 333 OMGs2, and 13 shared DEGs2 were detected. 3 TF-target gene pairs (SP1-LSP1, SPI1-FCGR1A, and STAT1-FCGR1A) were identified. …”
Get full text

The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression by Yayun Zheng, Xue Ma, Dongmei Su, Yue Zhang, Lin Yu, Fangfei Jiang, Xue Zhou, Ying Feng, Fang Ma

“…Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands. …”
Get full text

Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from Mycobacterium bovis BCG by Hui Wang, Xiaotian Li, Shuxian Wang, Ren Fang, Jiayin Xing, Ruiying Wu, Chunhui Zhang, Zhaoli Li, Ningning Song

“…Besides, this protein either promoted recalcitrance to the host immune response and induced pathological injury and inflammation. …”
Get full text

Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease by Haniye Ghasiyari, Mohammad Rostami-Nejad, Davar Amani, Kamran Rostami, Mohamad Amin Pourhoseingholi, Hamid Asadzadeh-Aghdaei, Mohammad Reza Zali

“…Upregulation of TLR4 and TLR9 suggests the contribution of gut microbiota or dysregulation of the immune response to commensal flora in small bowel mucosa in celiac patients.…”
Get full text

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring by Federico Sizzano, Sebastiano Collino, Ornella Cominetti, Daniela Monti, Paolo Garagnani, Rita Ostan, Chiara Pirazzini, Maria Giulia Bacalini, Daniela Mari, Giuseppe Passarino, Claudio Franceschi, Alessio Palini

“…This process could lead to an impairment of the immune response. However, little is known about the capability of the immune cells of elderly individuals to dynamically counteract the oxidative stress. …”
Get full text

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise by Madison R. Barshick, Kristine M. Ely, Keely C. Mogge, Lara M. Chance, Sally E. Johnson

“…A comparison of the exercise by diet contrasts revealed that horses supplemented with MSM contained a greater number of exercise-responsive genes (630; logFC > 0.2; q < 0.05) by comparison to the CON (237), with many of these mapping to the immune response (71) and cytokine signal transduction (60) pathways. …”
Get full text

pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…Considering the presence of an immune response directed to heat shock proteins (hsps) in autoimmune diseases and the immunoregulatory potential of these molecules, we evaluated the effect of a previous immunization with a genetic vaccine containing the mycobacterial hsp65 gene on EAE development. …”
Get full text

Immunomodulatory effects of mononuclear 5,6-epoxy-5,6-dihydro-1,10-phenanthroline platinum(II) complex by Stanisavljević Isidora, Živković Marija, Rajković Snežana, Obradović Milica, Jurišević Milena, Pavlović Slađana, Simović-Marković Bojana, Gajović Nevena, Ćorović Irfan, Jocić Miodrag, Kostić Andrija, Jovanović Ivan

“…In this study, the effects of this platinum(II) complex on the immune response were assessed. Peritoneal macrophages and splenocytes obtained from mice were treated with lipopolysaccharide (LPS)/Concanavalin A (ConA) along with platinum(II) complex and measurement of cytokine concentrations and immunophenotyping was performed. …”
Get full text

Helicobacter pylori luxS mutants cause hyperinflammatory responses during chronic infection by Christina Yang, Alessandra Rodriguez y Baena, Bryce A. Manso, Shuai Hu, Raymondo Lopez-Magaña, Mané Ohanyan, Karen M. Ottemann

“…These results suggest that H. pylori LuxS may play more of a role in modulating the immune response versus colonization.…”
Get full text

Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis by Anqi Wang, Sitong Yan, Weijia Jiang, Xiang Chen, Yuhan Huang, Xiangyu Zu, Xiao Du, Lulu Fan, Jiatao Liu, Guoping Sun

“…Enrichment analysis revealed that CLIP4 is involved in the immune response, cell adhesion, and EMT. There was a positive correlation between CLIP4 expression and the infiltration of the majority of immune cells, immunomodulators, and chemokines. …”
Get full text

Serum-Free Culture System for Spontaneous Human Mesenchymal Stem Cell Spheroid Formation by Guoyi Dong, Shengpeng Wang, Yuping Ge, Qiuting Deng, Qi Cao, Quanlei Wang, Zhouchun Shang, Wenjie OuYang, Jing Li, Chao Liu, Jie Tang, Weihua Zhao, Ying Gu

“…Interestingly, genes related to inflammatory response, immune response, and angiogenesis were upregulated in spheroids at day 6 and qPCR results further validated the increased expression level of related genes, including STC1, CCL7, HGF, IL24, and TGFB3. …”
Get full text

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development by Zhenxing Cheng, Simon T. Abrams, James Austin, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng Hock Toh, Guozheng Wang

“…The major outcome is to activate host immune response by inducing cytokine production. In this review, we focus on the roles and potential mechanisms of DNA sensors and downstream pathways in sepsis. …”
Get full text