Research progress of femoral head necrosis in HIV-infected patients by Youhan Yang, Futao Ke, Zhengqi Pan, Liaobin Chen

“…Potential contributing factors have been identified, including systemic immune response, inflammatory response, local microenvironmental changes in the femoral head, and the unique anatomical structure of the femoral head, among others. …”
Get full text

Multiple Sclerosis and Obesity: Possible Roles of Adipokines by José de Jesús Guerrero-García, Lucrecia Carrera-Quintanar, Rocío Ivette López-Roa, Ana Laura Márquez-Aguirre, Argelia Esperanza Rojas-Mayorquín, Daniel Ortuño-Sahagún

“…Second, we concentrate on the role of several adipokines that are able to participate in the mediation of the immune response in MS and on the possible cross talk between the latter. …”
Get full text

Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma by Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi

“…Furthermore, this vaccine displayed the capacity to modulate humoral and cellular immune responses. Overall, the results suggest therapeutic potential for the chimeric CD70-CPP-TNF vaccine against RCC. …”
Get full text

Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…Macrophages are key regulators of the innate immune response, as well as one of the first types of cells which respond to chemical stress, so the study of the action of TCDD on these cells is important. …”
Get full text

Characterization of HIV-1 Infection and Innate Sensing in Different Types of Primary Human Monocyte-Derived Macrophages by Elisabeth A. Diget, Kaja Zuwala, Randi K. Berg, Rune R. Laursen, Stine Søby, Lars Østergaard, Jesper Melchjorsen, Trine H. Mogensen

“…Paradoxically, the data show that the MDMs with the strongest innate immune response were also the most permissive for HIV-1 replication.…”
Get full text

Effect of opercular deformity on morphological and transcriptomic profiling of gills in golden pompano (Trachinotus ovatus) by Yuwei Wu, Qian Ma, Dihao Huang, Liuyong Wang, Qiling Zhou, Chunli Ran, Gang Chen

“…KEGG pathway enrichment analysis of the DEGs indicated notable enrichment in pathways related to immune response and inflammation, including Staphylococcus aureus infection, leukocyte transendothelial migration, tight junction, and cell adhesion molecules pathways. …”
Get full text

Serum Cytokine Profiles in Children with Crohn’s Disease by Ekaterina Vasilyeva, Sayar Abdulkhakov, Georgi Cherepnev, Ekaterina Martynova, Irina Mayanskaya, Alina Valeeva, Rustam Abdulkhakov, Dilyara Safina, Svetlana Khaiboullina, Albert Rizvanov

“…Immune mechanisms have been suggested to play an important role in CD pathogenesis, with cytokines governing the development of the immune response. Upregulation of inflammatory cytokines in serum of juvenile and adult CD patients has been documented; still little is known about age-dependent differences in serum cytokine profiles of CD patients. …”
Get full text

Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia by N. Yu. Chasovskikh, A. A. Bobrysheva, E. E. Chizhik

“…Such alterations could potentially lead to a change in the immune response. The data obtained contribute theoretically to the development of ideas about the molecular mechanisms through which hereditary factors in schizophrenia influence the interactions of proteins of the IL-1 family, which play an important role in the processes of the immune system.…”
Get full text

Advances in Microengineered Platforms for Skin Research by Sireesh Kumar Teertam, Vijayasaradhi Setaluri, Jose M. Ayuso

“…Researchers have used microfluidic platforms for a variety of applications in skin research, including epidermal–dermal cellular crosstalk, cell migration, mechanobiology, microbiome–immune response interactions, vascular biology, and wound healing. …”
Get full text

Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections by Joanna R. Wares, Joseph J. Crivelli, Chae-Ok Yun, Il-Kyu Choi, Jana L. Gevertz, Peter S. Kim

“…., allows the infection to initially thrive before the immune response is enhanced. Taken together, our work shows how the ordering, temporal spacing, and dosage of OV and DC can be chosen to maximize efficacy and to potentially eliminate tumors altogether.…”
Get full text

Identified VCAM1 as prognostic gene in gastric cancer by co-expression network analysis by Wenjuan Li, Hong Gao, Jianjun Liu

“…The prominent genes in the green module showed enrichment in processes such as signal transduction, immune response, and the positive regulation of GTPase activity. …”
Get full text

Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

“…The immune response following trauma represents a major driving force of organ dysfunction and poor outcome. …”
Get full text

Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights by Geqiang Wang, Yongji Li, Jiaxing Liu, Qian Zhang, Weixin Cai, Xiaodong Li

“…Notably, Cluster 2 was characterized by the upregulation of pathways pertinent to immune response and inflammation. Our research suggests that the CCT2, HSPA6, DNAJB14, and DNAJC5 exhibit potential as effective blood-based diagnostic biomarkers for AS. …”
Get full text

Clinical efficacy studies of the vaccine against feline panleukopenia, calicivirus infection and viral rhinotracheitis Carnifel PCH in kittens by T. S. Galkina, A. A. Komarova, A. M. Kiselev

“…Vaccines protect animals from diseases by inducing antibody production and cellular immune response. Primary and booster vaccinations are performed in accordance with the recommendations for the use of vaccines prescribed by the manufactures depending on the minimum duration of immunity. …”
Get full text

Infection Dynamics of Severe Acute Respiratory Syndrome Coronavirus-2 Wild-type and Delta Variant of Concern in a Pediatric Cohort in Southern India by Asha Jyothi Penugonda, Deepayan Biswas, Murugan Thimiri Palani, Sangeetha Priya, Rajesh Kumar Subaschandrabose, Koshy Alan Valiaveetil, Belavendra Antonisamy, Rajeev Zachariah Kompithra, Leni Grace Mathew, Mahesh Moorthy

“…Background: Dynamics, severity, and immune response of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection vary between children and adults. …”
Get full text

Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection by Jesús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Carlos A. Barrera-Ochoa, Janette Furuzawa-Carballeda

“…IL-10 is a regulatory cytokine that plays a central role in limiting host immune response to pathogen. Increased IL-10 levels were reported in H. pylori–infected gastric mucosa. …”
Get full text

Risk factors for re-hospitalization within 90 days of discharge for severe influenza in children by Shuo Yang, Sukun Lu, Can Qi, Yinghui Guo, Le Wang

“…Conclusions Our findings suggest that, to reduce the potential readmission of children with severe influenza, a sustained focus on the risk factors including rhinosinusitis and over-activated host immune response during the index hospitalization is needed.…”
Get full text

Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma by Pengxiang Gao, Qiuping Liu, Ziye Luo, Wenjun Pu, Wenjun Pu

“…The downregulated genes were linked to immune response and fatty acid metabolism. Metabolomic analysis showed major changes in lipid and choline metabolism. …”
Get full text

Unique or not unique? Comparative genetic analysis of bacterial O-antigens from the Oxalobacteraceae family by S. D. Afonnikova, A. S. Komissarov, P. D. Kuchur

“…Depending on the characteristics of its components, the bacteria can avoid the host’s immune response or establish a mutualistic relationship with it. …”
Get full text

The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

“…Inflammasomes, the multiprotein complexes that launch the innate immune response, emerge as important mediators in the pathogenesis of HCC. …”
Get full text