The Effects of Nigella Sativa (Black Seed) in Rhinosinusitis Subjects: A Systematic Review by Muhamad Najmi Muhamad Najemudin, Nurul Asyiqin Yusof

“… Introduction: Allergic rhinitis is a persistent inflammatory nasal condition triggered by an exaggerated immune response to allergens. Its primary complication is sinusitis which progresses to rhinosinusitis. …”
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Gene Expression Profiling in Dermatitis Herpetiformis Skin Lesions by M. Dolcino, E. Cozzani, S. Riva, A. Parodi, E. Tinazzi, C. Lunardi, A. Puccetti

“…Consistently with the autoimmune origin of DH, functional classification of the differentially expressed genes (DEGs) indicates a B- and T-cell immune response (LAG3, TRAF5, DPP4, and NT5E). In addition, gene modulation provides evidence for a local inflammatory response (IL8, PTGFR, FSTL1, IFI16, BDKRD2, and NAMPT) with concomitant leukocyte recruitment (CCL5, ENPP2), endothelial cell activation, and neutrophil extravasation (SELL, SELE). …”
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Cytokines and Metabolic Patterns in Pediatric Patients with Critical Illness by George Briassoulis, Shekhar Venkataraman, Ann Thompson

“…It is not known if cytokines, which are cell-derived mediators released during the host immune response to stress, affect metabolic response to stress during critical illness. …”
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Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity by Ali N. Kamali, Patricia Marín-García, Isabel G. Azcárate, Antonio Puyet, Amalia Diez, José M. Bautista

“…The presence of specific antibodies in vaccinated mice serum was studied by immunoblot analysis at different days after vaccination and showed an intensive immune response to a wide range of antigens with molecular weight ranging between 22 and 250 kDa. …”
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In Vivo Bioluminescence Visualization of Antitumor Effects by Human MUC1 Vaccination by Yong Hyun Jeon, Yun Choi, Hyun Joo Kim, Joo Hyun Kang, Chul Woo Kim, Jae Min Jeong, Dong Soo Lee, June-Key Chung

“…To determine the anti-hMUC1-associated immune response generated by pcDNA3.1 or pcDNA3-hMUC1, we determined the concentration of interferon-γ (IFN-γ) protein and CD8+IFN-γ cell numbers among lymphocytes from the draining lymph nodes of mice immunized with pcDNA3.1 or pcDNA3-hMUC1. …”
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Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy by Ahmet Yalcinkaya, Ahmet Yalcinkaya, Rumeysa Yalcinkaya, Fabian Sardh, Fabian Sardh, Nils Landegren, Nils Landegren

“…Biological sex is closely associated with the properties and extent of the immune response, with males and females showing different susceptibilities to diseases and variations in immunity. …”
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PPARγ and the Innate Immune System Mediate the Resolution of Inflammation by Amanda Croasdell, Parker F. Duffney, Nina Kim, Shannon H. Lacy, Patricia J. Sime, Richard P. Phipps

“…There are also roles for this receptor in the adaptive immune response, particularly regarding B cells. These effects contribute towards the attenuation of multiple disease states, including COPD, colitis, Alzheimer’s disease, and obesity in animal models. …”
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Structural characterization of two γδ TCR/CD3 complexes by Mohammed Hoque, John Benji Grigg, Trudy Ramlall, Jennifer Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome

“…Abstract The T-cell receptor (TCR)/CD3 complex plays an essential role in the immune response and is a key player in cancer immunotherapies. …”
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Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy by Wenhua Xu, Mingshan Ren, Swagata Ghosh, Kai Qian, Zhaofeng Luo, Aimei Zhang, Cuiping Zhang, Jiajun Cui

“…Myasthenia gravis (MG) is a CD4+ T cell-dependent autoimmune disease resulting from aberrant immune response mediated by circulating autoantibodies at the neuromuscular junction. …”
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A randomized, double‐blind, placebo‐controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease by Darren Bentley, Marie Mannino, Marianne Manchester, Priscila Camillo Teixeira, Bernhard Reis, Malcolm Boyce, Sandra Nagel

“…This randomized, double‐blind, placebo‐controlled, parallel‐group, single‐center study tested the effects of the cathepsin S inhibitor RO5459072 on the immune response to a 13‐day gluten challenge in 19 participants with celiac disease (ClinicalTrials.gov: NCT02679014). …”
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Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG) by Joan A. Chick, Nadege N. Abongdia, Robert A. Shey, Tobias O. Apinjoh

“…In-silico analysis revealed that the designed antigen, PfCTMAG (Plasmodium falciparum Circumsporozoite, Thrombospondin-related adhesion protein, Merozoite surface protein 2, Apical asparagine (Asn)-rich protein and Glutamate-Rich Protein), effectively bound to Toll-like receptor 4 (TLR-4) and triggered a strong immune response. In sero-reactivity studies, malaria-positives (cases) had higher anti-PfCTMAG IgG (p = 0.024) and IgM (p < 0.001) levels compared to malaria negatives (controls). …”
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Transcriptome-based insights into the calcium transport mechanism of chick chorioallantoic membrane by Qun Huang, Ran Yang, Qia Wang, Hui Teng, Hongbo Song, Fang Geng, Peng Luo

“…Functional enrichment analysis of DEGs showed that CAM DEGs were mainly involved in biological processes such as “ion transport regulation”, “immune response” and “cell cycle”. Time series analysis of the differential genes showed that the functional cells of CAM began to proliferate and differentiate at E9 and the calcium content of egg embryo increased significantly at E13. …”
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The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities by Zehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin

“…Traditionally, this state has been viewed as a tumor‐suppressing mechanism that prevents the proliferation of damaged cells while activating the immune response for their clearance. However, senescence is increasingly recognized as a contributing factor to tumor progression. …”
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Physiological and pathological roles of PGAM5: An update and future trend by Weibin He, Wenlong He, Zhongchan Sun, Pengcheng He

“…Additionally, we summarize some novel roles of PGAM5 in cellular senescence, lipid metabolism, and immune response modulation in recent studies. Finally, we discuss PGAM5’s contribution to the pathological state of cardiovascular, hepatic, neurological, and neoplastic diseases, offering potential perspectives for future research.…”
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Cloning and Characterization of Immunological Properties of Haemophilus influenzae Enolase by Yesenia Osorio-Aguilar, Maria Cristina Gonzalez-Vazquez, Patricia Lozano-Zarain, Ygnacio Martinez-Laguna, Alejandro Carabarin-Lima, Rosa del Carmen Rocha-Gracia

“…Both in silico and experimental results showed that recombinant enolase from H. influenzae is immunogenic that could induce a humoral immune response; this was observed mediating the generation of specific polyclonal antibodies anti-rNTHiENO that recognize typeable and nontypeable H. influenzae strains. …”
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Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice. by Avigail Ehrlich, Graziano Pelli, Bernard Foglia, Filippo Molica, Brenda R Kwak

“…Atherosclerosis is a progressive arterial disease arising from imbalanced lipid metabolism and a maladaptive immune response. The lymphatic system ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells to draining lymph nodes, thereby potentially affecting atherogenesis. …”
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Autoimmunity against cytokines: Double strike in autoimmune disease, a historical perspective by Iván Insignares, Luis E. Rodríguez, Óscar Correa-Jiménez, Alberto Alfaro-Murillo, Laura Rincón-Arenas, Andrés Sánchez, Marlon Múnera

“…This leads to an effector immune response against tissues expressing antigens, which are later recognized by the host immune system. …”
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Rotavirus VP6 Adjuvant Effect on Norovirus GII.4 Virus-Like Particle Uptake and Presentation by Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo by Kirsi Tamminen, Suvi Heinimäki, Timo Vesikari, Vesna Blazevic

“…The adjuvant effect of VP6 on GII.4 VLP presentation and NoV-specific immune response induction by BMDC in vivo was also studied. …”
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Peptide-Based Vaccinology: Experimental and Computational Approaches to Target Hypervariable Viruses through the Fine Characterization of Protective Epitopes Recognized by Monoclon... by Matteo Castelli, Francesca Cappelletti, Roberta Antonia Diotti, Giuseppe Sautto, Elena Criscuolo, Matteo Dal Peraro, Nicola Clementi

“…Defining immunogenic domains of viral proteins capable of eliciting a protective immune response is crucial in the development of novel epitope-based prophylactic strategies. …”
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Spontaneous Complete Regression of Colon Cancer Liver Metastases in a Lung Transplant Patient: A Case Report by Koen Zwart, Dieuwertje Ruigrok, Magda de Graaf-Bos, Roel Goldschmeding, Miriam Koopman, Guus M. Bol

“…Disinhibition and reset of the host immune response could have led to immune destruction of the liver metastases of this patient’s immunogenic dMMR colon carcinoma. …”
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