Transcriptional Profiling of Testis Development in Pre-Sexually-Mature Hezuo Pig by Zunqiang Yan, Qiaoli Yang, Pengfei Wang, Shuangbao Gun

“…Additionally, chemokine, B cell receptor, activation of immune response, and enzyme binding were enriched in macrophages. …”
Get full text

CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells by Lin Xu, Chunhong Wang, Zhenke Wen, Ya Zhou, Zhongmin Liu, Yongjie Liang, Zengguang Xu, Tao Ren

“…Here we firstly reported that CpG-ODNs could significantly enhance the antitumor efficacy of adoptively transferred TILs in vivo accompanied by enhanced activity capacity and proliferation of CD8+ T cells and CD8+ T cells, as well as a Th1 polarization immune response. Most importantly, we found that CpG-ODNs could significantly elevate the infiltration of Th17 cells in tumor mass, which contributed to anti-tumor efficacy of TILs in vivo. …”
Get full text

The role of natural products targeting macrophage polarization in sepsis-induced lung injury by Yake Li, Sinan Ai, Yuan Li, Wangyu Ye, Rui Li, Xiaolong Xu, Qingquan Liu

“…Abstract Sepsis-induced acute lung injury (SALI) is characterized by a dysregulated inflammatory and immune response. As a key component of the innate immune system, macrophages play a vital role in SALI, in which a macrophage phenotype imbalance caused by an increase in M1 macrophages or a decrease in M2 macrophages is common. …”
Get full text

T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease by Uroosa Ibrahim, Gwenalyn Garcia, Amina Saqib, Shafinaz Hussein, Qun Dai

“…The pathophysiology is thought to involve cytokine-mediated evasion of T cell immune response by malignant B cells. It usually presents at an advanced stage with extranodal involvement. …”
Get full text

Detection and Role of Some Interleukins and Tumor Necrotic Factor Alpha among Patients with Tuberculosis by Wael Rasheed Obaead Alfatlawi, Marwa Kadhim Khudhair, Jwan Ahmed Ali

“…Conclusions: IL-2, IL-10, and IL-17 were significant components of the immune response to TB; their distinct profiles, obtained from easily accessible kits, might be used to diagnose TB cases. …”
Get full text

Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

“…Cathelicidins are a group of cationic, amphipathic peptides that play a vital role in the innate immune response of many vertebrates, including humans. …”
Get full text

Role of High-Density Lipoprotein Cholesterol (HDL-C) as a Clinical Predictor of Decompensation in Patients with Chronic Liver Disease (CLD) by Harshavardhan Rao B, Priya Nair, Anoop K. Koshy, S. Krishnapriya, C. R. Greeshma, Rama P. Venu

“…High-density lipoprotein cholesterol (HDL-C) has a significant role in innate immune response to LPS in the circulation and could therefore increase the risk for decompensation in patients with CLD. …”
Get full text

Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation by Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Pao-Yuan Lin, Fu-Chan Wei, Chao-Long Chen

“…The mechanisms by which MSCs modulate the immune response are still under thorough investigation, but these most likely involve expression of local factors influencing T-cell regulation, modulation of cytokine expression (e.g., IL-10, TGF-β, TNF-, INF-γ, etc.), and interactions with dendritic or antigen presenting cells. …”
Get full text

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer by Qin Fang, Shuru Chen, Xiaoyue Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu

“…BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly understood. …”
Get full text

Heme alters biofilm formation in Mycobacterium abscessus by Hadia Aftab, Jessica Samudio, Grace Wang, Lily Le, Rajesh K. Soni, Rebecca K. Donegan

“…During infection, Mabs can form biofilms in the lung which reduce both the ability of the immune response to clear infection and the effectiveness of antibiotic therapy. …”
Get full text

Health Status of Spiny Lobster Panulirus homarus with Sub-Mersible Net Cage System in the Different Depths at Kepulauan Seribu, DKI Jakarta by Dinamella Wahjuningrum, Irzal Effendi, Yani Hadiroseyani, Tatag Budiardi, Iis Diatin, Mia Setiawati, Yuni Puji Hastuti, Agus Oman Sudrajat, Yonvitner, Sri Nuryati, Putri Utami

“…Based on the above observations, the depth does not affect the immune response, there is no visible damage to the cells and tissues of the lobster hepatopancreas. …”
Get full text

Screening key genes for intracranial aneurysm rupture using LASSO regression and the SVM-RFE algorithm by Qi Wu, Chunli Yang, Cuilan Huang, Zhiying Lin

“…Further functional analysis suggested that the DEGs were enriched in inflammation and immune response pathways. Fourteen hub genes were identified using the two algorithms. …”
Get full text

Chelate compounds and their use for correction of trace element deficiencies in livestock (review) by A. G. Koshchaev, N. E. Gorkovenko, A. V. Kosykh, D. V. Antipova

“…Due to the immunostimulatory activity resulting from increase in the content of sialic acids, properdin, ceruloplasmin, gamma globulin protein fraction, the metal chelates (copper, cobalt, iodine) can be used as immune response modulators. Iron chelate compounds are used for therapy and prevention of iron deficiency anemias not only in veterinary, but also in human medicine. …”
Get full text

Wogonin Attenuates Ovalbumin Antigen-Induced Neutrophilic Airway Inflammation by Inhibiting Th17 Differentiation by Rie Takagi, Masaaki Kawano, Kazuyuki Nakagome, Kumiko Hashimoto, Takehiro Higashi, Katsuya Ohbuchi, Atsushi Kaneko, Sho Matsushita

“…Allergic airway inflammation is generally considered to be a Th2-type immune response. Recent studies, however, have demonstrated that Th17-type immune responses also play important roles in this process, particularly in the pathogenesis of neutrophilic airway inflammation, a hallmark of severe asthma. …”
Get full text

Why Does Pnemococcus Kill? by Yves Bergeron, Michel G Bergeron

“…While many virulence factors have been associated with fatal pneumococcal pneumonia. there is growing evidence that some components of the immune response contribute significantly to the high mortality rate. …”
Get full text

Long-term sublingual bacterial immunotherapy prevents ear, nose and throat infections: A real-life study by Paula F Aarestrup, Matheus F Aarestrup, Beatriz JV Aarestrup, Edir P Cheloni, Fernando M Aarestrup

“…Recent findings suggest that immunity can be trained by inducing an immunological memory in both the innate and acquired immune response. This real-life observational study investigated the potential of sublingual bacterial immunotherapy in the prevention of ear, nose, and throat infections. …”
Get full text

Rational engineering of minimally immunogenic nucleases for gene therapy by Rumya Raghavan, Mirco J. Friedrich, Indigo King, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, Blake Lash, Michael Kilian, Michael Platten, Rhiannon K. Macrae, Yifan Song, Lucas Nivon, Feng Zhang

“…In vivo editing of PCSK9 with SaCas9.Redi.1 is comparable in efficiency to wild-type SaCas9, but significantly reduces undesired immune responses. This demonstrates the utility of this approach in engineering proteins to evade immune detection.…”
Get full text

Systemic immune-inflammation index and the short-term mortality of patients with sepsis: A meta-analysis by Lingbo Liang, Qiaoli Su

“… The systemic immune-inflammation index (SII) is a novel biomarker that reflects the balance between the host immune response and inflammation, two key pathophysiological processes involved in sepsis. …”
Get full text

Autoserum: An Optimal Supplement for Bone Marrow Mesenchymal Stem Cells of Liver-Injured Rats by Qinglin Zhang, Xun Sun, Jianxun Ding, Ping He, Yujia Liu, Hongjing Cheng, Changlin Zhou, Xiangwei Meng

“…Although the use of adult serum, platelet lysate, or cord blood serum solves some of the problems caused by fetal bovine serum (FBS), the allogeneic immune response, contamination, and donor-to-donor and donor-to-receptor differences still obstruct the application of MSCs. …”
Get full text

IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome by Shujuan Li, Ming Yu, Haifeng Li, Hongliang Zhang, Yanfang Jiang

“…Meanwhile, the elevated levels of these two cytokines in plasma suggest the activation of Th17 and Th22 cells in the systemic immune response of GBS. Our data provide preliminary evidence that GBS is associated with high levels of IL-17 and IL-22 in CSF and plasma. …”
Get full text