Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Dise... by Kang Tang, Chunmei Zhang, Yusi Zhang, Yun Zhang, Ran Zhuang, Boquan Jin, Ying Ma

“…Haemorrhagic fever with renal syndrome (HFRS) is characterised by an uncontrolled immune response that causes vascular leakage. Adiponectin (APN) is an adipocytokine involved in prorevascularisation and immunomodulation. …”
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Helminth Parasites and the Modulation of Joint Inflammation by Chelsea E. Matisz, Jason J. McDougall, Keith A. Sharkey, Derek M. McKay

“…Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. …”
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Potentiating intratumoral therapy with immune checkpoint inhibitors: shifting the paradigm of multimodality therapeutics by B.E. Nelson, A. Naing, S. Fu, R.A. Sheth, R. Murthy, S. Piha-Paul

“…Overall, combining ITs with ICIs offers a rational strategy to potentiate antitumor immune response and overcome resistance. Further research is needed to optimize the combination strategies, identify biomarkers of response, and establish the safety and efficacy of these novel therapeutic approaches.…”
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Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients by Figen Deveci, H. Handan Akbulut, Ilhami Celik, M. Hamdi Muz, Fulya İlhan

“…These cells could play important roles in the immune response to M tuberculosis infection.…”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…Since detrimental immune response is crucially responsible for the development and aggravation of DED, therapeutic agents which modulate phenotype and function of eye-infiltrated inflammatory immune cells could be used for the treatment of severe DED. …”
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Deciphering CSU pathogenesis: Network toxicologyand molecular dynamics of DOTP exposure by Fang Cao, Cui Guo, Jing Guo

“…GO and KEGG analyses were utilized to explore target functions, particularly in inflammation and immune response pathways. AutoDock was employed for molecular docking to predict DOTP's binding to core targets, followed by molecular dynamics simulations with Gromacs to observe detailed interactions and conformational changes in the target proteins. …”
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Immunotherapy of osteosarcoma based on immune microenvironment modulation by Heping Lian, Heping Lian, Jiakui Zhang, Shuna Hou, Shuang Ma, Jiachen Yu, Wei Zhao, Duoyi Zhao, Zhiyu Zhang

“…The immunosuppressive microenvironment in osteosarcoma is the main reason for the ineffectiveness of immunotherapy, in which the low immune response rate of immune effector cells and the high activation of immunosuppressive cells contribute to this outcome. …”
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Bioinformatics Analysis of miRNAs Targeting TRAF5 in DLBCL Involving in NF-κB Signaling Pathway and Affecting the Apoptosis and Signal Transduction by Chunyao Li, Lanshan Huang, Yongqin Wen, Muhua Yi, Min Gao

“…DEGs were significantly concentrated in the NF-κB signaling pathway and cytokine-cytokine receptor interaction, and involved in the process of immune response and protein binding. MiR-15a-5p, miR-147a, miR-192-5p, miR-197-3p, miR-532-5p, and miR-650 were revealed to be targeting TRAF5 and participating in NF-κB signaling pathway and might impact the apoptosis and signal transduction of DLBCL. …”
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Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge by Wenyi Gu, Wenyi Gu, Jiajing Zhao, Yu Xu, Yu Xu, Yu Xu

“…As HUA is a metabolic syndrome, the immune response is likely to play an active role throughout the whole process. …”
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The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model by Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Joanna Rossowska, Agnieszka Szczygieł, Natalia Anger-Góra, Bożena Szermer-Olearnik, Magdalena Geneja, Elżbieta Pajtasz-Piasecka

“…Application of the developed DC-based vaccines may exert a favorable impact on stimulation of an antitumor immune response, especially if these DC vaccines are administered repeatedly.…”
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A unique case report on campylobacter rectus infection leading to acute motor axonal neuropathy in a pediatric patient by Uchechukwu Ibewuike, MBBS, John Kim, MD, Swati Mody, MBBS, Gregory Obala, MD, Ebere Ibezim, MBBS

“…Acute motor axonal neuropathy (AMAN), a subtype of Guillain-Barré Syndrome, arises from an atypical immune response, frequently initiated by infections caused by Campylobacter jejuni, although other infectious agents have also been identified. …”
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Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells by Fangming Xiu, Mile Stanojcic, Li Diao, Marc G. Jeschke

“…Along with others, we hypothesize that reduction in morbidity and mortality observed in patients receiving insulin treatment is partially due to its effect on the attenuation of the immune response. However, there still remains substantial controversy regarding moderate versus intensive insulin treatment. …”
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Immunological Impacts of Diabetes on the Susceptibility of Mycobacterium tuberculosis by Birhanu Ayelign, Markos Negash, Meaza Genetu, Tadelo Wondmagegn, Tewodros Shibabaw

“…In addition, impaired immune response and killing of intracellular bacteria potentially increase bacterial load, chronic inflammation, and central necrosis that facilitate bacterial dissemination and miliary tuberculosis. …”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…Target genes were detected by double-luciferase and pull down assays. qRT-PCR and Western blot were performed to analyze the expression of several important proteins involved in the immune response pathway, including coronin-1, interleukins (IL-10), forkhead transcription factor 1 (FOXO1), nucleotide-binding oligomerization domain protein (NOD) 1, NOD2, and receptor-interacting protein (RIP) 2. …”
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Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy by Kai-Uwe Jarr, Manfred Nelles, Hugo A. Katus, Emmanuel Chorianopoulos

“…Further research will be necessary to elucidate the exact role of sTWEAK as a potential modulator of immune response in the setting of dilated cardiomyopathy.…”
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Scrub typhus association with autoimmune biomarkers and clinical implications. by Hwanseung You, Jeongeun Song, Seonglyeong Kim, Sang-Min Oh, Joo-Hee Hwang, Jeong-Hwan Hwang, Wan-Hee Yoo, Yunjung Choi, Chang-Seop Lee

“…The distribution of ANA titers revealed a progressive increase in mean ANA and double-stranded deoxyribonucleic acid Immunoglobulin M (anti-dsDNA IgM) titers as the duration after symptom onset increased, indicating an augmented immune response over time. This trend was observed along with a systematic elevation in median anti-dsDNA IgM titers, highlighting the dynamic nature of immune responses in scrub typhus infection.…”
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Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…Encouraging SBRT-PATHY-clinical outcomes, along with immunohistochemical and gene-expression analyses of surgically removed abscopal-tumor sites, suggested that delivery of the high-dose radiation to the partial tumor volume, with optimal timing based on the homeostatic fluctuation of the immune response and sparing the peritumoral immune-environment, would significantly enhance the immune-mediated anti-tumor effects.…”
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In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation by Matthew J. Hardwick, Ming-Kai Chen, Kwamena Baidoo, Martin G. Pomper, Tomás R. Guilarte

“…The ability to visualize the immune response with radioligands targeted to immune cells will enhance our understanding of cellular responses in inflammatory diseases. …”
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Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats by Seungae Park, Na-Young Park, Giuseppe Valacchi, Yunsook Lim

“…Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a high fat diet induced obesity (HF group). …”
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HIFU-CCL19/21 Axis Enhances Dendritic Cell Vaccine Efficacy in the Tumor Microenvironment by Bum-Seo Baek, Hyunmi Park, Ji-Woong Choi, Eun-Young Lee, Seung-Yong Seong

“…This study examines the potential of combining mechanical high-intensity focused ultrasound (M-HIFU) with dendritic cell (DC) vaccines to enhance immune responses against OLFM4-expressing tumors, a CSC marker linked to immune evasion and tumor growth. …”
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