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961
The Application of Single-Cell RNA Sequencing in Vaccinology
Published 2020-01-01“…Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. …”
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962
Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis
Published 2018-01-01“…These differentially expressed genes (DEGs) are involved in apoptosis, stress and stimulus response, placental and embryonic development, immune response, and cell adhesion. Therefore, these results provide information on the molecular mechanisms that E. faecalis invasion can trigger to cause adverse pregnancy outcomes.…”
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963
CD47/SIRPα axis: bridging innate and adaptive immunity
Published 2022-07-01“…Myeloid immune cells are frequently present in the tumor environment, and although they can positively contribute to tumor control they often negatively impact anticancer immune responses. One way of inhibiting the positive contributions of myeloid cells is by signaling through the cluster of differentiation 47 (CD47)/signal regulatory protein alpha (SIRPα) axis. …”
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964
Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes
Published 2018-01-01“…It was predicted that IL-6, JUN, and TP53, along with transcription factors SRC, TNF, and MAPK14, could regulate the immune response, with their function being extracellular region activity and protein binding during infection with M. tuberculosis.…”
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965
Structure simulation-based comparison of active site variations in fungal ornithine decarboxylases
Published 2025-12-01“…Polyamines play crucial roles in various biological processes, including cell proliferation and differentiation, immune response modulation, and signal transduction. Ornithine decarboxylase (ODC) initiates polyamine biosynthesis by catalyzing the conversion of ornithine to putrescine in a pyridoxal phosphate (PLP)-dependent manner. …”
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966
3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists
Published 2023-01-01“…These data suggest that compound 6 induces an innate immune response by agonizing TLR7 activity in THP1 human monocytic cells. …”
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967
Inborn errors of immunity (primary immunodeficiencies)
Published 2025-01-01“…The treatment of IEIs is complex and generally requires both supportive and definitive strategies, including but not limited to, immunoglobulin replacement therapy, antibiotic prophylaxis, immune response modifiers, and hematopoietic stem cell transplantation. …”
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968
Microbiome interplays in the gut-liver axis: implications for liver cancer pathogenesis and therapeutic insights
Published 2025-01-01“…In this review, we present the concept of Gut-Liver Axis and its function in the mutual influence between gut microbiota and PLC from several aspects in which we will focus on the structure of gut barrier and the functional influences the gut microbiota have on the immune response and metabolic changes on human liver. …”
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969
PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors
Published 2011-01-01“…The phosphatidylinositol 3-kinase (PI3K) pathway regulates multiple cellular processes which underlie immune responses against pathogens or malignant cells. …”
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970
Pro-angiogenic effects of Guo Min decoction in a zebrafish model
Published 2025-01-01“…Although GMD treatment was reported to treat allergy-associated symptoms by regulating the immune response, the rationale between GMD treatment and angiogenesis has not been reported yet. …”
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971
Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult
Published 2011-01-01“…This case of fatal ANE in an adult is consistent with the hypothesis generated from pediatric cases that the host immune response, and not direct viral invasion of the CNS, is responsible for pathogenesis of ANE.…”
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972
Exploring the link between gut health, diet, and food allergy
Published 2024-09-01“…Changes in the gut microbiota, whether due to dietary habits, fiber consumption, the hygiene hypothesis, proton pump inhibitors, non-steroidal anti-inflammatory drugs, antibiotic use, supplementation and other factors, can potentially influence the immune response leading to the development and severity of food allergy. …”
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973
Hubungan Nilai Laju Endap Darah (LED) dengan Kadar C-Reactive Protein (C-RP) pada Pasien Positif Covid-19
Published 2022-01-01“…SARS-CoV-2 infection is a systemic infection that significantly affects hematopoiesis and the patient's immune response. Drastic increase in the production of proinflammatory cytokines like interleukin-6 (IL-6) play a role in mechanism of lymphopenia in COVID-19. …”
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974
Mannose-binding lectin gene sequence data in Kelantan population
Published 2024-04-01“…Abstract The human mannose-binding lectin (MBL) gene encodes a polymorphic protein that plays a crucial role in the innate immune response. Human MBL deficiency is associated with immunodeficiencies, and its variants have been linked to autoimmune and infectious diseases. …”
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975
The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
Published 2012-01-01“…One of the main features of the immune response to M. Tuberculosis is the formation of an organized structure called granuloma. …”
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976
Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy
Published 2010-01-01“…They play a vital role in the initiation of immune response by presenting antigens to T cells and followed by induction of T-cell response. …”
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977
Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training
Published 2023-12-01“…Conclusion: In response to noise stress, previous exercise, especially HIIT, increased stress while did not increase inflammatory and innate immune response.…”
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978
Hepatitis E rORF2p Stimulated and Unstimulated Peripheral Expression Profiling in Patients with Self-Limiting Hepatitis E Infection
Published 2014-01-01“…The observed upregulations of inhibitory, integrin, activatory, and Treg-associated cytokine genes on the PBMCs of acute HEV patients complemented by their frequency data suggest them as the major players in the fine-tuning of immune response in self-limiting hepatitis E infection.…”
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979
Dysregulation of NK and CD8+T Cells by the Microbiota Promotes the Progression of Lung Cancer
Published 2022-01-01“…Alterations in the amount and dominant species of the microbiota can reshape the immune response of the body and lead to a variety of lung diseases, including cancer. …”
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980
Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology?
Published 2012-01-01“…In addition, astrocytes, oligodendrocytes, endothelial cells, and, to a lesser extent, neurons are implicated in the immune response in the central nervous system. By modulating synaptogenesis, microglia are most specifically involved in restoring neuronal connectivity following injury. …”
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