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841
Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens
Published 2024-04-01“…In the case of vaccines, they allow for modulation and increase of the immune response. Lipopeptides are molecules of choice because of their ability to activate specific cell surface receptors, penetrate the outer membrane of GNB, safety and ease of synthesis. …”
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842
Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview
Published 2012-01-01“…SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. …”
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843
Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity.
Published 2024-12-01“…Transcriptomic analysis of colonic spheroids uncovered no evidence of dimer-dependent target gene miss-regulation, confirmed impaired stem cell maintenance in-vitro, and discovered an elevated signature of epithelial innate immune response to symbionts, a likely underlying cause for heightened sensitivity in NDD mice. …”
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844
Actinomycotic osteonecrosis of the maxilla as a post-covid sequelae: A case report
Published 2024-03-01“…The dysregulated immune response from COVID-19 infection predisposes patients to opportunistic infections. …”
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845
Viruses Seen by Our Cells: The Role of Viral RNA Sensors
Published 2018-01-01“…The role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. …”
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846
Imaging of CD47 Expression in Xenograft and Allograft Tumor Models
Published 2013-11-01“…CD47 has been shown to be overexpressed by various tumor types as a means of escaping the antitumor immune response. The goal of this research was to investigate the utility of CD47 imaging using positron emission tomography (PET) in both human xenograft and murine allograft tumor models. …”
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847
Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma
Published 2025-01-01“…However, the heterogeneity of tumor immune response causes more than half of patients to not benefit from clinical immunotherapy and targeted therapy, which delays the patient’s condition and causes them to suffer adverse immune events’ side effects. …”
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848
Hemizygous Moesin (MSN) Gene Deletion in an Adult With Chronic Neutropenia
Published 2024-01-01“…It is characterized by cytopenias, hypogammaglobulinemia, poor immune response to vaccine antigens, and increased susceptibility to early-life infections. …”
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849
A mathematical model for within-host Toxoplasma gondii invasion dynamics
Published 2012-06-01“…The model considers theinvasion process, egress kinetics, interconversion between fast-replicatingtachyzoite stage and slowly replicating bradyzoite stage, as well as thehost's immune response. Analytical and numerical studies of the model can helpto understand the influences of various parameters to the transient andsteady-state dynamics of the disease infection.…”
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850
Comparison of Effects of Smoking and Smokeless Tobacco “Maras Powder” Use on Humoral Immune System Parameters
Published 2006-01-01“…Effects of Maras powder on humoral immune response were found to be similar to that of smoking.…”
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851
Exosome-Derived microRNA: Potential Target for Diagnosis and Treatment of Sepsis
Published 2024-01-01“…This review comprehensively explores the biology of exosome-derived miRNAs, which originate from both immune cells (such as macrophages and dendritic cells) and nonimmune cells (such as endothelial and epithelial cells) and play a dynamic role in modulating pathways that affect the course of sepsis, including those related to inflammation, immune response, cell survival, and apoptosis. Taking into account these dynamic changes, we further discuss the potential of exosome-derived miRNAs as biomarkers for the early detection and prognosis of sepsis and advantages over traditional biomarkers due to their stability and specificity. …”
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852
Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses
Published 2012-01-01“…By better defining the role of genetic variability in influenza infection and identifying key polymorphisms that impair the host immune response or correlate with protection, we will be able to better identify at-risk populations and new targets for therapeutic interventions and vaccines. …”
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853
A mathematical model for M-phase specific chemotherapy including the $G_0$-phase and immunoresponse
Published 2007-01-01“…In this paper we use a mathematical model to study the effect ofan $M$-phase specific drug on the development of cancer, includingthe resting phase $G_0$ and the immune response. The cell cycle ofcancer cells is split into the mitotic phase (M-phase), thequiescent phase ($G_0$-phase) and the interphase ($G_1,\ S,\G_2$ phases). …”
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854
BK Polyomavirus and acute kidney injury in transplant recipients: signaling pathways and molecular mechanisms
Published 2025-01-01“…Although reactivation is often asymptomatic, it can present as AKI, which is a risk factor for early loss of the transplanted organ. The immune response to BKPyV is crucial in controlling the virus and safeguarding organs from damage during infection. …”
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855
The dynamics of CD4+ T cell proliferation and regulation
Published 2025-12-01“…We use mathematical modeling to study the proliferation dynamics of CD4+ T cells within an immune response. This proliferation is driven by the autocrine reaction of helper T cells and interleukin-2 (IL-2), and regulated by natural regulatory T cells (nTregs). …”
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856
Bacteriophages: Uncharacterized and Dynamic Regulators of the Immune System
Published 2019-01-01“…Here, we aim to fill this gap by providing an overview of bacteriophage communities in the gut during human development, detailing recent findings for their bacterial-mediated effects on the immune response and summarizing the latest evidence for direct interactions between them and the immune system. …”
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857
Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases
Published 2021-01-01“…We, therefore, summarized the mechanisms underlying the MSC immune response, especially the interaction between MSCs and the liver microenvironment, discussing how to achieve better therapeutic effects.…”
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858
AhR governs lipid metabolism: the role of gut microbiota
Published 2025-01-01“…Under physiological conditions, AhR mainly participates in regulating the body’s immune response, cell proliferation, and apoptosis among a series of processes. …”
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859
Stability Analysis and Clinic Phenomenon Simulation of a Fractional-Order HBV Infection Model
Published 2020-01-01“…The basic reproductive number R0 and the cytotoxic T lymphocytes’ immune-response reproductive number R1 were derived. There were three equilibrium points of the model, and stable analysis of each equilibrium point was given with corresponding hypothesis about R0 or R1. …”
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860
Glioblastoma Multiforme Stem Cells
Published 2011-01-01“…The endogenous immune regulation is likely to limit or abrogate the efficacy of the host's immune response, as well as the developed immunotherapeutic strategies at present. …”
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