Borrelia burgdorferi Tolerance-Associated Changes in Gene Expression of Murine Macrophages by Sophia Chen, Ricki Deng, Anis Hadi, Sara Nandwana, William Ryan, John B. Presloid, R. Mark Wooten

“…Macrophages, key cellular players in the innate immune response, exhibit diminished functionality over time during Bb infection, potentially leading to chronic infection. …”
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The Possible Correlation between the Patient's Immune Tolerance Level During Cesaerean Section and the Incidence of Subsequent Emergency Peripartum Hysterectomy by Lukasz Wicherek, Krystna Galazka

“…Conclusion. Abnormal immune response during labor may increase the risk for peripartum hysterectomy.…”
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Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers by I. V. Lyadova, A. V. Panteleev

“…CD4+ T cells play critical role during Mtb infection by mediating protection, contributing to inflammation, and regulating immune response. Th1 and Th17 cells are the main effector CD4+ T cells during TB. …”
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Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier by Shanshan Chen, Ruonan He, Beihui He, Li Xu, Shuo Zhang

“…Exosomal lncRNAs are involved in immune cell differentiation and the modulation of the immune response. This review briefly introduces the potential role of exosomal lncRNAs in the intestinal mucosal immune barrier and discusses their relevance to intestinal illnesses.…”
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Inherited glycosylphosphatidylinositol deficiency disorders: a new group of inherited metabolic disorders by Michał Patalan, Alicja Leśniak, Justyna Paprocka, Agnieszka Zubkiewicz-Kucharska, Kaja Giżewska-Kacprzak, Marta Glińska, Lidia Babiak-Choroszczak, Maria Giżewska, Robert Śmigiel

“…These glycosylphosphatidylinositol-anchored proteins are an important part of receptors, function as hydrolytic enzymes, and play a crucial role in molecules adhesion, immune response, embryogenesis and neurogenesis. Patients present a variety of symptoms including developmental delay with intellectual disability, abnormalities of the central nervous, skeletal, circulatory, gastrointestinal, and urinary systems, facial dysmorphia as well as hearing and visual impairment. …”
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Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications by Monde Ntwasa, Akira Goto, Shoichiro Kurata

“…Initial research reports, however, indicate that coleopterans possess unique immune response mechanisms, and studies of these novel mechanisms may help to further elucidate innate immunity. …”
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Posttranslational Modifications and the Immunogenicity of Biotherapeutics by Roy Jefferis

“…The individual is naturally tolerant to molecular forms of self-molecules but nonself variants can provoke an immune response with the generation of anti-drug antibodies (ADA); aggregated forms can exhibit enhanced immunogenicity and QC procedures are developed to avoid or remove them. …”
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Macrophage Migration Inhibitory Factor in Protozoan Infections by Marcelo T. Bozza, Yuri C. Martins, Letícia A. M. Carneiro, Claudia N. Paiva

“…In the present paper, we discussed the participation of MIF in the immune response to protozoan parasite infections. As a general trend, MIF participates in the control of parasite burden at the expense of promoting tissue damage due to increased inflammation.…”
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Extreme Rhabdomyolysis, Acute Renal Failure, and Protracted Ileus in a Case of Legionella Pneumonia by C. Laivier, M.-O. Bleuze, P. Hantson, J. Devos

“…This case illustrates the apparent discrepancy between the pulmonary symptoms and the extrapulmonary manifestations that could be seen as a consequence of an exaggerated immune response.…”
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Seronegative autoimmune hepatitis by A. O. Buyeverov

“…Absence of elevated serum γ-globulins, immunoglobulin G and autoantibodies is most commonly seen in acute onset of the disease that is probably caused by delay of humoral immune response of the disease. According to available information one can postulate following: 1) clinical vigilance for SAH, especially at liver diseases with high biochemical activity; 2) performing liver biopsies in all cases of unclear diagnosis; 3) application of standard scoring diagnostic system at autoimmune hepatitis; 4) prescription of immunosuppressive therapy at justified suspicion for SAH (at ruling out of the other causes for liver disease). …”
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Chondrosternal Arthritis in Infant: An Unusual Entity by Athina Nikolarakou, Dana Dumitriu, Pierre-Louis Docquier

“…It is a self-limiting affection due to the adequate immune response of the patient. Evolution is generally good without antibiotherapy with a progressive spontaneous healing. …”
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Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease by Sheetal Verma, Tamisha Vaughan, Kevin D. Bunting

“…In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation. …”
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Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment by Yifu Shu, Jing Li

“…Immune infiltration was assessed via ssGSEA, while transwell assays and immunofluorescence examined the effects of disulfidptosis-Tex genes on glioma cell behavior and immune response.ResultsEleven disulfidptosis-Tex genes were found critical for glioblastoma survival outcomes. …”
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Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab by Oscar Otero-Marquez, Mona Fayad, Alexander Pinhas, Toco Y. P. Chui, Richard B. Rosen, Harsha S. Reddy

“…Retinal surface macrophages play key roles in the regulation of immune response, maintenance of vitreous clarity, and tissue repair. …”
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Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis by Jiang Chen, Guo Xiao-Zhong, Xing-Shun Qi

“…The effects of specific immunotherapy were compared with those of nonspecific immunotherapy and the meta-analysis was executed with results regarding the overall survival (OS), immune responses data, and serum cancer markers data. The pooled analysis was performed by using the random-effects model. …”
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Engineering CRISPR for emerging therapeutic applications by Xiaoqi Sun, Zhuang Liu

“…Clustered regularly interspaced short palindromic repeats (CRISPRs) were originally identified in bacterial and archaeal genomes as an adaptive immune response against invading viruses and phages. The discovery of the ability of CRISPR–Cas9 to cut targeted DNA sequences at predetermined sites has introduced a new era of precision and flexibility in genome editing. …”
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Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK by Patrick M. Stuart, Tammie L. Keadle

“…Chief among these differences is the fact that recurrent HSK takes place in the context of an animal that has a preexisting anti-HSV immune response, while primary HSK occurs in an animal that is developing such a response. …”
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Alcoholism and Inflammatory Response: Implications for Liver and Cardiovascular Disease by Christian Gabriel Acosta Ricachi, Sheila Ivette Quinapanta Serrano, Álvaro Paúl Moina Veloz

“…Among the main mechanisms that cause these injuries are: alterations in the immune response, increased oxidative stress and methylation alterations. …”
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Assessment of the Combined Effects of Heavy Metal Cobalt and Sublethal Radiation on the Immune System by Gulzhan Ilderbayeva, Aigul Utegenova, Oralbek Ilderbayev, Zhibek Sembaeva, Gulsum Askarova

“…Methods: The main immunosuppressive manifestation of the toxic dose of cobalt on the humoral component of the immune response is noted. Results: There is a decrease in the concentration of immunoglobulins (Igs) of the main classes in blood serum by 17%–30% (P < 0.05). …”
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Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity by Lucille Rankin, Gabrielle T. Belz

“…While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered opening exciting new directions for investigation. …”
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