Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development by Micaella Kantor, Anarella Abrantes, Andrea Estevez, Alan Schiller, Jose Torrent, Jose Gascon, Robert Hernandez, Christopher Ochner

“…As more is learned about its pathogenesis and the host’s immune response, the potential for developing a vaccine holds promise. …”
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T Cell Costimulatory Molecules in Anti-Viral Immunity: Potential Role in Immunotherapeutic Vaccines by Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen

“…By providing antigens and costimulatory molecules together, investigators may be able to increase and broaden the immune response, resulting in better immunological control or even elimination of the infection. …”
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Asthma in Children and Adults: A Shared Biological and Molecular Basis by Paolo M Renzi

“…A comparison of the reported clinical presentation, physiological changes, histology and cellular biology of asthma in different age groups is presented with special emphasis on the abnormal immune response, cellular activation and lymphokine production. …”
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Analysis of a cancer dormancy model and control of immuno-therapy by Ben Sheller, Domenico D'Alessandro

“…We identify an equilibrium point corresponding to a survivable amount of cancer cells which are exactly balanced by the immune response. This situation corresponds to cancer dormancy. …”
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In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases by Neeladri Chowdhury, Atsushi Asakura

“…Moreover, patient-derived cells can be used for experimental transplantation into nonhuman animal embryos via in utero injection as the immune response is absent at such early stages of development. …”
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Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model by Alissa N. Threatt, Jade White, Jade White, Nathan Klepper, Nathan Klepper, Zachary Brier, Zachary Brier, Logan S. Dean, Logan S. Dean, Ash Ibarra, Macallister Harris, Kaylee Jones, Maëlis J. L. Wahl, Melea Barahona, Melea Barahona, Emmanuel O. Oyewole, Morgan Pauly, Julie A. Moreno, Julie A. Moreno, Tara M. Nordgren

“…We observed a significant pulmonary and neurological immune response to DE characterized by the development of inducible bronchus associated lymphoid tissue in the lung and gliosis in the frontal areas of the brain. …”
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Revealing the role of natural killer cells in ankylosing spondylitis: identifying diagnostic biomarkers and therapeutic targets by Yuling Chen, Yan Li, Yuan Xu, Qing Lv, Yuanchun Ye, Jieruo Gu

“…IL2RB, CD247, PLEKHF1, EOMES, S1PR5, FGFBP2 from the MElightyellow module were identified as key genes involved in NK cell-mediated immune response and served as potential diagnostic biomarkers for AS, with moderate to high diagnostic values based on AUC values. …”
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Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets by Yijiang Bei, Linqiang He, Jin Jing, Xiaoming Chen, Fan Yuan, Gaohua Yao, XueYan Ding, Lei Wang, Fan Zhou

“…DEGs associated with nutrient metabolism and immune responses provide insights for optimizing protein levels in aquaculture feed formulations. …”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…These insights underscore TUBA1B’s multifaceted role in cancer progression and immune response.Conclusion: This study highlights TUBA1B’s potential as a human oncogene with substantial roles in tumorigenesis and immune regulation. …”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…In conclusion, our study unveils a distinct phenotype in aged microglia characterized by compromised immune responsiveness. Through the integration of in vitro cultured BV-2 microglia with primary microglia datasets, we identify critical molecular determinants of microglial cellular aging confirmed in human-aged brain tissue. …”
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A SH3b domain-containing peptidoglycan recognition protein from Magallana gigas with broad recognition spectrum by Yinan Li, Hongbo Lu, Chuanyan Yang, Zhuyun Liu, Weilin Wang, Chang Liu, Lingling Wang

“…Peptidoglycan recognition protein (PGRP) is a kind of conserved pattern recognition receptors (PRRs) and plays important roles in innate immune response in both invertebrates and vertebrates. …”
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Application of synbiotic with different probiotic doses to prevent vibriosis in humpback grouper by Dwi Agung Saputra, , Sukenda, , Widanarni

“…After a feeding trial period, there were observation of the bacterial counts in the fish intestine, the fish growth performance and immune response. Then all the grouper were challenged by Vibrio alginolyticus, except K (-). …”
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The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…The greatest number of functional differences was observed between relatives and controls (69 pathways), from which 15% of the pathways belonged to “immune response-related” processes. In the T1D versus controls comparison, more pathways (24%) were classified as “immune response-related.” …”
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Inhibition of Vibrio parahaemolyticus infection in whiteleg shrimp reared in a biofloc system with different volumes by Surandha Bako, Widanarni Widanarni, Julie Ekasari, Munti Yuhana

“…Furthermore, the biofloc treatment with a volume of 15 mL/L demonstrated the best results compared to other treatments in decreasing PVC and V. parahaemolyticus population as evidenced by the immune response, survival rate, and growth performance of whiteleg shrimp.   …”
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Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…HIV-1 control efforts with reliance on immunotherapy remain at a conceptual stage due to the complexity of a set of processes that regulate the dynamics of infection and immune response. For this reason, it is extremely important to use methods of mathematical modeling of HIV-1 infection dynamics for theoretical analysis of possibilities of reducing the viral load by affecting the immune system without the usage of antiviral therapy. …”
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Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients by Lucile Dumolard, Marie-Noelle Hilleret, Marie-Noelle Hilleret, Charlotte Costentin, Charlotte Costentin, Marion Mercey-Ressejac, Marion Mercey-Ressejac, Nathalie Sturm, Nathalie Sturm, Theophile Gerster, Thomas Decaens, Thomas Decaens, Evelyne Jouvin-Marche, Patrice N. Marche, Zuzana Macek Jilkova, Zuzana Macek Jilkova

“…BackgroundPatients with chronic hepatitis B virus (HBV) infection are characterized by impaired immune response that fails to eliminate HBV. Immune checkpoint molecules (ICMs) control the amplitude of the activation and function of immune cells, which makes them the key regulators of immune response.MethodsWe performed a multiparametric flow cytometry analysis of ICMs and determined their expression on intrahepatic lymphocyte subsets in untreated and treated patients with HBV in comparison with non-pathological liver tissue.ResultsThe liver of untreated HBV patients exhibited a high accumulation of PD-1+CD8+ T cells, while the frequencies of 4-1BB+ T cells, 4-1BB+ natural killer (NK) cells, and TIM-3+CD8+ T cells were the highest in the chronic hepatitis phase. …”
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Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination by Katja Uršič Valentinuzzi, Katja Uršič Valentinuzzi, Urška Kamenšek, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Chloe Heranney, Tilen Komel, Tilen Komel, Simon Buček, Simon Buček, Maja Čemažar, Maja Čemažar, Gregor Serša, Gregor Serša

“…Variances in the antitumor (immune) response were also detected based on the chemotherapeutic drug used in ECT. …”
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Immunoprotective effect of chitosan nanoparticles with different particle sizes against H9N2 avian influenza infection by Shangen Xu, Zhi Zhao, Chenxi Sun, Yile Ji, Qingshuang Luan, Qihong Zhang, Zheng Jin, Kai Zhao

“…Subsequent in vivo immunogenicity screening revealed that H9N2 with the 272.5 ± 7.0 nm NHC NPs vaccine group induced higher levels of neutralizing antibodies in the early stage of the immune response, while the 343.2 ± 8.0 nm NHC NPs vaccine group induced higher levels of neutralizing antibodies in the late stages of the immune response. …”
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Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection by Mark R. Schleiss

“…A better understanding of immune responses that prevent and/or predispose to infection will help in the development of novel vaccine strategies.…”
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The Immunomodulatory Potential of Wharton’s Jelly Mesenchymal Stem/Stromal Cells by Fernanda Vieira Paladino, Juliana de Moraes Rodrigues, Aline da Silva, Anna Carla Goldberg

“…This text highlights information on how WJ-MSC affect immune responses in comparison with other sources of MSC.…”
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