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741
Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases
Published 2025-06-01“…Autoimmune rheumatic diseases (ARDs) are a heterogeneous group of conditions characterized by excessive and misdirected immune responses against the body's own musculoskeletal tissues. …”
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742
NK-DC Crosstalk in Immunity to Microbial Infection
Published 2016-01-01“…We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.…”
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743
Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application
Published 2010-01-01“…Toll-like receptors (TLRs) are known to be expressed by innate immune response cells and to play a critical role in their activation against foreign pathogens. …”
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744
Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection
Published 2025-01-01“…The resultant reprogramming can lead to activation of oncogenes, silencing of tumor suppressor genes, and evasion of the immune response, which ultimately contributes to the oncogenic potential of these viruses. …”
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745
The role of TNF-α inhibitor in glioma virotherapy: A mathematical model
Published 2016-12-01“…Virotherapy, using herpes simplex virus, represents a promising therapy of glioma. But the innate immune response, which includes TNF-α produced by macrophages, reduces the effectiveness of the treatment. …”
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746
Toll-Like Receptor 4 Activation in Cancer Progression and Therapy
Published 2011-01-01“…Cancer immunotherapy has been the focus of intense research since the late 19th century when Coley observed that bacterial components can contribute to cancer regression by eliciting an antitumor immune response. Successful activation and maturation of tumor-specific immune cells is now known to be mediated by bacterial endotoxin, which activates Toll-like receptor 4 (TLR4). …”
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747
COMPARISON OF REACTOGENICITY AND IMMUNOGENICITY OF LIVE VACCINES AGAINST INFECTIOUS LARYNGOTRACHEITIS
Published 2018-05-01“…Humoral immune response and ciliary activity of tracheal mucosa of poultry, vaccinated against infectious laryngotracheitis using ciliostatic test, was studied. …”
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748
Treatment options of human demodicosis
Published 2024-12-01“…Cutaneous and ocular demodicosis most often occurs in a situation of impaired immune response, where the attacked organism is weakened, has reduced immunity or metabolic disorders. …”
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749
Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease
Published 2015-01-01“…Studies have reported that these exogenous and endogenous components may perturb the balance of innate immune response by activating the NLRP3 inflammasome. …”
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750
Statistical identification of cell type-specific spatially variable genes in spatial transcriptomics
Published 2025-01-01“…Applied to five real datasets, Celina uncovers ct-SVGs associated with tumor progression and patient survival in lung cancer, identifies metagenes with unique spatial patterns linked to cell proliferation and immune response in kidney cancer, and detects genes preferentially expressed near amyloid-β plaques in an Alzheimer’s model.…”
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751
Serum levels of TNF-α, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease
Published 2002-01-01“…Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-α, interleukin-1beta (IL-1β), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. …”
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752
Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms
Published 2025-01-01“…Abstract Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. …”
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753
The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent
Published 2018-01-01“…Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease. …”
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754
Relapse of Visceral Leishmaniasis in an HIV-Infected Patient Successfully Treated with a Combination of Miltefosine and Amphotericin B
Published 2015-01-01“…The present report documents a 49-year-old HIV-infected man receiving antiretroviral therapy with a suboptimal immune response and a CD4 count of 95 cells/mm3, despite virological suppression. …”
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755
The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases
Published 2020-01-01“…TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. …”
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756
Rhinovirus-Induced Exacerbations of Asthma and COPD
Published 2013-01-01“…While the innate immune response likely plays a role in rhinovirus-induced exacerbations, its precise role, either adaptive or maladaptive, is debated. …”
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757
Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury
Published 2012-01-01“…Evidence from preclinical models cites mechanisms of organ crosstalk during ischemic AKI including the expression of cellular adhesion molecules, lymphocyte trafficking, release of proinflammatory cytokines and chemokines, and modification of the host innate and adaptive immune response systems. In this paper, the influence of kidney IRI on systemic inflammation and distant organ injury will be examined. …”
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758
Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions
Published 2017-01-01“…Pathogens have evolved unique mechanisms to breach the cell surface barrier and manipulate the host immune response to establish a productive infection. Proteins exposed to the extracellular environment, both cell surface-expressed receptors and secreted proteins, are essential targets for initial invasion and play key roles in pathogen recognition and subsequent immunoregulatory processes. …”
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759
Mechanisms behind Functional Avidity Maturation in T Cells
Published 2012-01-01“…During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. …”
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760
Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target
Published 2017-01-01“…It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. …”
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