Global Stability of HIV-1 Infection Model with Two Time Delays by Hui Miao, Xamxinur Abdurahman, Ahmadjan Muhammadhaji

“…The effect of time delay on stability of the equilibria of the CTL immune response model has been studied.…”
Get full text

Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis by Jason Kerkvliet, Ramakrishna Edukulla, Moses Rodriguez

“…Here, we discuss the structure and function of 3Dpol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3Dpol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3Dpol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3Dpol is causing this antiviral effect in mice.…”
Get full text

Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease by Francisca Cornejo, Rommy von Bernhardi

“…Here, we review the participation of the immune response mediated by glial cells in Alzheimer’s disease and the role played by scavenger receptors in the development of this pathology, focusing on the relevance of class A scavenger receptor (SR-A) for Aβ clearance and inflammatory activation of glial cell, and as a potential target for Alzheimer’s disease therapy.…”
Get full text

Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies by Emma Camacho, Gustavo A. Niño-Vega

“…In this review focusing on the pathogen perspective, we will discuss some of the microbial attributes and molecular mechanisms that enable Paracoccidioides spp. to tolerate, adapt, and ultimately avoid the host immune response, establishing infection.…”
Get full text

Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract by E. F. Barinov, O. N. Sulayeva

“…Intestinal myofibroblasts are pacemakers for smooth myocytes of GIT, they modulate neurotransmission, participate in modulation of immune response, playing a critical role in reparation of erosions and ulcers of GIT.…”
Get full text

Clinical Perspectives - Biologics in IBD: What's All the Fuss? by Hillary Steinhart

“…With greater understanding of the specific pathways of the gut mucosal immune response, it is hoped that newer biologic response modifiers will provide better efficacy, with an improved adverse event profile compared with older existing therapies. …”
Get full text

Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity by Sandra Winning, Joachim Fandrey

“…Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. …”
Get full text

Oncolytic Immunotherapy: Where Are We Clinically? by Akseli Hemminki

“…Thus, the relative contribution of “pure” oncolysis, the immune response resulting from oncolysis, and the added benefit of adding a transgene remain poorly understood. …”
Get full text

Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions by Rodrigo Bibiloni, Eduardo J. Schiffrin

“…In addition global alterations of the microbiota that can play a role in the initiation of an exaggerated inflammatory response through an abnormal signaling of the innate and adaptive immune response are briefly described.…”
Get full text

Should Genetics Be Blamed for High Incidence of Uterine Disease in Dairy Cows? by Klibs N. Galvão, Christopher M. Seabury, Pablo Pinedo

“…This 3-page fact sheet presents the results of a recent paper that examined how alterations on the TLR genes, which control innate immune response, affect the susceptibility to uterine diseases. …”
Get full text

Diet as therapeutic intervention in Crohn’s disease by Martyna Więcek, Paulina Panufnik, Karolina Pomorska, Konrad Lewandowski, Grażyna Rydzewska

“…It has an impact on microbiome, host barrier, and immune response. Clinical studies indicate that various dietary interventions such as exclusive enteral nutrition and exclusion diets might be useful for induction of remission in mild to moderate Crohn’s disease, but also for patients failing biological therapy. …”
Get full text

Cytokine gene regulation by PGE2, LTB4 and PAF by M. Rola-Pleszczynski, J. Stankova

“…The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. …”
Get full text

Spread of odontogenic infection in puerperium: A case report and review of literature by Mujtaba Bala, Mohammad Abubakar Kaura, Anas Bawa Tsafe, Olufemi Ibrahim Adigun, Laraba Lawan Ahmadu

“…Although puerperium is associated with many physiological changes, including the risk of infection and reduced immune response, the spread of odontogenic infection is rare. …”
Get full text

Modelling and analysis of a delayed viral infection model with follicular dendritic cell by Yan Geng, Jinhu Xu

“…In this paper, we propose a new viral infection model by incorporating a new compartment for follicular dendritic cell (FDC), nonlinear incidence, CTL immune response, and two intracellular delays. The main purpose of the paper is to make an improvement and supplement to the global dynamics of the model proposed by Callaway and Perelson (2002), in which global stability has not been studied. …”
Get full text

Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells by Julio Aliberti

“…Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted proinflammatory immune responses to innocuous antigens or commensals. On the other hand, these cells must discriminate between commensal flora and invading pathogens and mount powerful immune response against pathogens. …”
Get full text

Role of Complement in Multiorgan Failure by Daniel Rittirsch, Heinz Redl, Markus Huber-Lang

“…Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. …”
Get full text

Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma by Wanda Stankiewicz, Marek P. Dabrowski, Andrzej Chcialowski, Tadeusz Plusa

“…In addition to diverse effector mechanisms, the cellular and humoral elements participating in the development of immune response may appear to be different in COPD and bronchial asthma (BA) patients.…”
Get full text

Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80+ liver-associated macrophages by Chitsuda Pongma, Pornlapat Keawvilai, Atsadang Boonmee, Benjawan Wongprom, Thitiporn Pattarakankul, Chutamath Sittplangkoon, Mohamad-Gabriel Alameh, Patipark Kueanjinda, James Heyes, Kieu Lam, Benjawan Saechue, Kiat Ruxrungtham, Tanapat Palaga

“…Abstract Delivery of an mRNA formulated with lipid nanoparticles (LNPs) induces robust humoral and cell-mediated branches of the immune response. Depending on the LNP formula, mRNA encoding proteins can be detected in the liver upon intramuscular administration of mRNA/LNP in mice. …”
Get full text

Age influences the circulating immune profile in pediatric sepsis by Grace Fisler, Grace Fisler, Grace Fisler, Mariana R. Brewer, Mariana R. Brewer, Mariana R. Brewer, Omar Yaipen, Clifford S. Deutschman, Clifford S. Deutschman, Clifford S. Deutschman, Matthew D. Taylor, Matthew D. Taylor, Matthew D. Taylor

“…BackgroundThe immune response changes as patients age, yet studies on the immune dysregulation of sepsis often do not consider age as a key variable.ObjectiveWe hypothesized that age would influence the immune response in septic children and that there would be a distinct variation in the immune profile in healthy children and children with either sepsis, uncomplicated infection, or acute organ dysfunction without infection. …”
Get full text

Demineralized Freeze-Dried Bovine Cortical Bone: Its Potential for Guided Bone Regeneration Membrane by David B. Kamadjaja, Achmad Harijadi, Pratiwi Soesilawati, Eny Wahyuni, Nurul Maulidah, Akhsanal Fauzi, Fika Rah Ayu, Roberto Simanjuntak, R. Soesanto, Djodi Asmara, Andra Rizqiawan, Peter Agus, Coen Pramono

“…In vivo study exhibited increased immune response to DFDBCBM in early healing phase; however, normal tissue response and degradation rate were observed up to 4 weeks after DFDBCBM implantation. …”
Get full text