Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. by Kevin N Couper, Tom Barnes, Julius C R Hafalla, Valery Combes, Bernhard Ryffel, Thomas Secher, Georges E Grau, Eleanor M Riley, J Brian de Souza

“…This study therefore establishes parasitized red blood cell-derived MPs as a major inducer of systemic inflammation during malaria infection, raising important questions about their role in severe disease and in the generation of adaptive immune responses.…”
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The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review by Punitha Letchumanan, Kumitaa Theva Das

“…Sex-specific factors were also shown to play an important role with females, showing stronger early immune responses and higher representation among elite controllers. …”
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Antigen-Induced Immunomodulation in the Pathogenesis of Atherosclerosis by Natalia Milioti, Alexandra Bermudez-Fajardo, Manuel L. Penichet, Ernesto Oviedo-Orta

“…The present review summarises the most important scientific findings published within the last two decades on the importance of antigens, antigen stimulation, and adaptive immune responses in the development of atherosclerotic plaques.…”
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Increased thyroxine levels of patients with allergic rhinitis by Violeta Lokaj-Berisha, Besa Gacaferri Lumezi

“…The study highlights the complex interplay between metabolic, endocrine, and immune responses in respiratory allergies. Elevated serum IgE levels and alterations in thyroid function, particularly among males, suggest potential pathways for targeted therapeutic interventions. …”
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Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment by Katherine M. Ranard, Bruce Appel

“…Low DHA status is linked to altered immune responses, white matter defects, impaired vision, and an increased risk of psychiatric disorders during development. …”
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Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. by Xiaoyuan Lin, Beibei Fu, Yan Xiong, Na Xing, Weiwei Xue, Dong Guo, Mohamed Zaky, Krishna Pavani, Dusan Kunec, Jakob Trimpert, Haibo Wu

“…In addition to structural proteins such as Spike and Envelope, the functional roles of non-structural and accessory proteins in regulating viral life cycle and host immune responses remain to be understood. Here, we show that open reading frame 8 (ORF8) acts as messenger for inter-cellular communication between alveolar epithelial cells and macrophages during SARS-CoV-2 infection. …”
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Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages. by Elaine Carvalho de Oliveira, Rafael Tibúrcio, Gabriela Duarte, Amanda Lago, Léon de Melo, Sara Nunes, Gustavo Gastão Davanzo, Ana Júlia Martins, Bruno Vinagre Ribeiro, Deborah Mothé, Juliana B P Menezes, Patrícia Veras, Natalia Tavares, Pedro M Moraes-Vieira, Cláudia Ida Brodskyn

“…Here, we demonstrate that despite differences in their mechanisms for evading host immune responses, L. amazonensis and L. braziliensis induce comparable disruptions in key metabolic pathways. …”
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Therapeutic Approaches in COVID-19 Patients: The Role of the Renin-Angiotensin System by Farzaneh Ketabchi, Sina Jamzad

“…However, the administration of COX inhibitors can reduce innate immune responses and have the opposite effect. A few studies suggest benefits of low-dose radiation therapy (LDR) in treating acute respiratory distress syndrome in COVID-19 patients. …”
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TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells by Wenyi Gu, Jiezhong Chen, Lei Yang, Kong-Nan Zhao

“…Tumour necrosis factor-α, interferon-γ and interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours. In this study, we investigated the effects of three cytokines on CD40 expression in Myb-transformed hematological cells and their regulatory roles in promoting these cells into dendritic cells. …”
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Transcytosis of T4 Bacteriophage Through Intestinal Cells Enhances Its Immune Activation by Amanda Carroll-Portillo, October Barnes, Cristina N. Coffman, Cody A. Braun, Sudha B. Singh, Henry C. Lin

“…Given that phages reside in the same body niches as bacteria, they share the propensity to stimulate or quench immune responses depending on the nature of their interactions with host immune cells. …”
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The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights by Zhuo Huang, Zhuo Huang, Qinyan Yao, Qinyan Yao, Shuang Ma, Shuang Ma, Jinjie Zhou, Jinjie Zhou, Xiaoxuan Wang, Xiaoxuan Wang, Qingguo Meng, Qingguo Meng, Yaxin Liu, Yaxin Liu, Zihan Yu, Zihan Yu, Xin Chen, Xin Chen

“…The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. …”
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Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients by Othman Abdul-Malak, Yoram Vodovotz, Akram Zaaqoq, Jesse Guardado, Khalid Almahmoud, Jinling Yin, Brian Zuckerbraun, Andrew B. Peitzman, Jason Sperry, Timothy R. Billiar, Rami A. Namas

“…Multiple mediators of the innate and lymphoid immune responses in the BD ≥ 4 group were elevated differentially upon admission and up to 16 h after injury. …”
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Recent advances in nutritional metabolism studies on SARS-CoV-2 infection by Yufen Jiang, Linle Xu, Xuexing Zheng, Hongbo Shi

“…By monitoring metabolic changes, infection severity can be predicted early, and modulating these metabolic pathways may help reduce inflammatory responses, improve immune responses, and reduce the risk of thrombosis. Research on the relationship between metabolism and SARS-CoV-2 infection provides an important scientific basis for addressing the global challenge posed by COVID-19, however, further studies are needed to validate these findings and provide more effective strategies for disease control.…”
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Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease by Joseph M. Gaballa, Caley Valdez, Douglas G. Mack, Faiz Minhajuddin, Masoom Raza, Tabrez A. Mohammad, Allison K. Martin, Andrew Getahun, Charles A. Dinarello, Andrew P. Fontenot, Shaikh M. Atif

“…Overall, our study shows that B cell recruitment and aggregate formation during CBD depend on sequential activation of innate and adaptive immune responses.…”
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Nanomaterials–plants–microbes interaction: plant growth promotion and stress mitigation by Gurleen Kaur Sodhi, Tharuka Wijesekara, Kailash Chand Kumawat, Priyanka Adhikari, Kuldeep Joshi, Smriti Singh, Beatrice Farda, Rihab Djebaili, Enrico Sabbi, Fares Ramila, Fares Ramila, Fares Ramila, Devendra Sillu, Gustavo Santoyo, Sergio de los Santos-Villalobos, Ajay Kumar, Marika Pellegrini, Debasis Mitra

“…Concurrently, their antimicrobial and protective properties provide resilience against biotic stressors, including pathogens and pests, by promoting plant immune responses and optimizing microbial-plant symbiosis. …”
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Polarization of ILC2s in Peripheral Blood Might Contribute to Immunosuppressive Microenvironment in Patients with Gastric Cancer by Qingli Bie, Pan Zhang, Zhaoliang Su, Dong Zheng, Xinyu Ying, Yumin Wu, Huijian Yang, Deyu Chen, Shengjun Wang, Huaxi Xu

“…Newly identified nuocytes or group 2 innate lymphoid cells (ILC2s) play an important role in Th2 cell mediated immunity such as protective immune responses to helminth parasites, allergic asthma, and chronic rhinosinusitis. …”
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

“…Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses. Using the fluid percussion injury (FPI) mouse model, we investigated the therapeutic efficacy of Rovelizumab, an agent that blocks ITGB2. …”
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Galectin 9 rescues the inducibility of IL-10 expression in regulatory B cells of patients with food allergy by Huang Huang, Minyao Li, Shuo Song, Shiyu Feng, Xiaoyang Feng, Yu Liu, Pingchang Yang, Pengyuan Zheng

“…Abstract The deregulation of immune responses is what causes food allergy (FA) to occur. …”
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Tumor microbiome: roles in tumor initiation, progression, and therapy by Shengxin Zhang, Jing Huang, Zedong Jiang, Huan Tong, Xuelei Ma, Yang Liu

“…Additionally, tumor microbiome is closely associated with drug resistance and influences therapeutic efficacy by modulating immune responses, drug metabolism, and apoptotic pathways. …”
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Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort by Boniphace Sylvester, Dinah B. Gasarasi, Said Aboud, Donath Tarimo, Siriel Masawe, Rose Mpembeni, Göte Swedberg

“…However, the effect of that exposure to subsequent immune responses has not been fully elucidated. This study aimed at determining the effect of prenatal exposure to P. falciparum on Interleukin-10 and Interferon-γ responses during clinical malaria episodes in the first 24 months of life. …”
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