Alloreactive-free CAR-VST therapy: a step forward in long-term tumor control in viral context by Valentine Wang, Barbara Savoldo, José-Arthur Guimaraes, Gianpietro Dotti, Loïc Reppel, Loïc Reppel, Danièle Bensoussan, Danièle Bensoussan

“…This review provides a comprehensive overview of CAR-VST development, emphasizing strategies to mitigate immunogenicity, such as using a specialized TCR, and approaches to improve therapeutic persistence against host immune responses. In this review, we discuss the production methods of CAR-VSTs and explore optimization strategies to enhance their functionality, activation profiles, memory persistence, and exhaustion resistance. …”
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Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccina... by Caroline Kuhn, Holm Zerbe, Hans-Joachim Schuberth, Anke Römer, Debby Kraatz-van Egmond, Claudia Wesenauer, Martina Resch, Alexander Stoll, Yury Zablotski

“…Potential non-specific effects of the vaccine on maternal innate immune responses and disease susceptibility during the sensitive transition period have not been addressed so far. …”
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Insights from in vivo preclinical cancer studies with histotripsy by Tejaswi Worlikar, Timothy Hall, Man Zhang, Mishal Mendiratta-Lala, Michael Green, Clifford S. Cho, Zhen Xu

“…Promising preclinical results including local tumor suppression, improved survival outcomes, local and systemic anti-tumor immune responses, and histotripsy-induced abscopal effects have been reported in various animal tumor models. …”
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It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma by Christin Knickmeier, Gaetan Aime Noubissi Nzeteu, Bernhard F. Gibbs, Frederik J. H. Hoogwater, Maarten W. Nijkamp, Maximilian Bockhorn, N. Helge Meyer

“…The therapeutic potential of targeting Gal-9, either alone or in combination with other immune checkpoint inhibitors such as anti-PD-L1, is also discussed, highlighting preclinical findings that suggest promising avenues for enhancing anti-tumor immune responses. By elucidating the complex biological activities of Gal-9 and its interactions within the TIME, this review underscores the importance of innovative therapeutic strategies aimed at mitigating the immunosuppressive effects of Gal-9 in PDAC.…”
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Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides by Bing Wei, Ran Zhang, Jingbo Zhai, Junfeng Zhu, Fangli Yang, Dan Yue, Xiaoyi Liu, Changlong Lu, Xun Sun

“…Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. Dysregulated immune responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis. …”
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Virally-initiated pain states: phenotypes, mechanisms, and future directions by Sara A. Dochnal, Steven P. Cohen, Mark R. Hutchinson, Mark R. Hutchinson, Mark R. Hutchinson, Yury I. Miller, Tony L. Yaksh

“…These virally induced pain states can arise through direct viral replication within neurons, or indirectly, via immune responses to infection in both the contexts of afferent signaling in the dorsal root ganglion (DRG) or subsequent higher order integration in intracranial systems. …”
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Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis by Jun-Qi Yang, Yonghua Zhou, Ram Raj Singh

“…Invariant natural killer T (iNKT) cells are unique subset of innate-like T cells recognizing glycolipids. iNKT cells can rapidly produce copious amounts of cytokines upon antigen stimulation and exert potent immunomodulatory activities for a wide variety of immune responses and diseases. We have revealed the regulatory effect of iNKT cells on autoimmunity with a serial of publications. …”
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Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer by Dorota Diakowska, Krzysztof Grabowski, Mirosław Nienartowicz, Paweł Zarębski, Kamila Fudalej, Krystyna Markocka-Mączka

“…Although significant relation between o-LAB level and CRC is observed, it may be rather the result of individual differences in the host immune responses against cancer.…”
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Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma by Fei Peng, Fang Zhu, Baodi Cao, Liang Peng

“…Biological enrichment analysis revealed CASP8’s association with critical cellular activities and immune responses. In the tumor microenvironment, CASP8 showed correlations with various immune cell types. …”
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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells by Bum-Ho Bin, Juyeon Seo, Sung Tae Kim

“…Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses. Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells. …”
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Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment by Lu Y, Li Z, Zhu X, Zeng Q, Liu S, Guan W

“…Immunotherapy has attracted much attention because of its ability to activate tumor-specific immune responses for tumor killing. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is an innate immune pathway that activates antitumor immunity by producing type I interferons. …”
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Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies by Hana Yeh, Matthew A. De Cruz, Yang You, Seiko Ikezu, Tsuneya Ikezu

“…Upon withdrawal of doxycycline, this monoclonal microglial cell line differentiates, resembling in vivo microglial physiology as demonstrated by the expression of microglial genes, innate immune responses, chemotaxis, and phagocytic abilities. …”
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Advances in Illuminating Prostate Cancer with Emerging Phototherapies by Ali Usman

“…PDT employs photosensitizers to produce reactive oxygen species, thereby stimulating anti-tumor immune responses, disrupting the tumor microvasculature and/or inducing aopotitic or necrotic cell death. …”
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Uncovering NK cell sabotage in gut diseases via single cell transcriptomics. by Hansong Lee, Dai Sik Ko, Hye Jin Heo, Seung Eun Baek, Eun Kyoung Kim, Eun Jung Kwon, Junho Kang, Yeuni Yu, Ninib Baryawno, Kihun Kim, Dongjun Lee, Yun Hak Kim

“…Overall, we elucidated the comprehensive UC and CRC immune microenvironments and NK cell-mediated immune responses. Our findings can aid in selecting therapeutic targets that increase the efficacy of immunotherapy.…”
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Immunotherapeutic Potential of Lactobacillus Species as Immune Checkpoint Inhibitors in Cancer Immunotherapy by Renukadevi J, Sam Helinto J, Prena D

“…These probiotics influence immune responses through interactions with immune cells such as dendritic cells, macrophages, and T cells. …”
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A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes by Chang Gong, Jennifer J. Linderman, Denise Kirschner

“…The model also predicts a dual role for granuloma development in LNs during Mtb infection: in early phases of infection granulomas suppress infection by providing additional antigens to the site of immune priming; however, this induces a more rapid reactivation at later stages by disrupting immune responses. We identify mechanisms that strongly correlate with better host-level outcomes, including elimination of uncontained lung granulomas by inducing low levels of lung tissue damage and inhibition of bacteria dissemination within the lung.…”
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Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer by Said SS, Ibrahim WN

“…Emerging evidence suggests that the gut microbiota plays a pivotal role in modulating immune responses at the tumor site and may even influence treatment outcomes in cancer patients receiving ICIs. …”
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Platelet microparticles level in juvenile idiopathic arthritis: A pediatric population-based cross-sectional study in a tertiary care center by Naresh Kumar, K Anu Punnen, Sukesh Chandran Nair, Visalakshi Jayaseelan, T Sathish Kumar

“…Background: Platelet-derived microparticles (PMPs) are small vesicles that are released from the plasma membrane upon platelet activation, which are then involved in haemostasis, vascular health, and have recently been shown to be intimately involved in immune responses. Aims and Objectives: We aimed to evaluate the level of plasma Platelet-derived micro particles in children with JIA and to assess the relationship between PMP levels and disease activity in JIA. …”
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Effect of amniotic fluid on hair follicle growth by Gamze Tumentemur, Elif Ganime Aygun, Bulut Yurtsever, Didem Cakirsoy, Ercument Ovali

“…Both irradiated (FAFI) and non-irradiated (FAF) hAF were assessed for their efficacy and safety in promoting hair growth and modulating immune responses in a rat model of hair loss. The study examined HF regeneration, transition to the anagen phase, and macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype.Results: Both FAF and FAFI treatments significantly increased HF density, with FAFI exhibiting enhanced effects. …”
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Centrality of Hygienic Honey Bee Workers in Colony Social Networks by Adrian Perez, Brian R. Johnson

“…This work highlights the importance of considering the benefits of remaining socially integrated in important information networks and the temporal limitations for how quickly organized immune responses can occur in response to potential infections.…”
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