Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer by Junko Tsuchida, Masayuki Nagahashi, Kazuaki Takabe, Toshifumi Wakai

“…Sphingosine-1-phosphate (S1P) is a pleiotropic, bioactive lipid mediator that regulates many cellular functions, including proliferation, migration, survival, angiogenesis/lymphangiogenesis, and immune responses. S1P is formed in cells by sphingosine kinases and released from them, which acts in an autocrine, paracrine, and/or endocrine manner. …”
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Monoamine neurotransmitters in breast cancer: Progression, immunomodulation, and therapeutic strategies by Saeed Mahdianipur, Mahafarin Maralani, Homa Davoodi

“…In the tumor microenvironment, serotonin and norepinephrine generally exhibit pro-tumorigenic effects, while dopamine has shown promising anti-tumor activity by enhancing immune responses. Histamine also shows potential in anti-tumor immunity, although its effects on breast cancer progression remain inconclusive. …”
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Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets by Giovanna Morello, Antonio Gianmaria Spampinato, Sebastiano Cavallaro

“…Among these, inflammatory/immune responses have recently gained particular interest, although there are conflicting reports on the role of these processes in ALS pathogenesis and treatment. …”
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Inflammation, immunity, and vaccines by R. Gong, M. Gerhard

“…Innate and adaptive immune responses are induced after H. pylori infection. …”
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Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy by Shuyan He, Lu Zheng, Chunjian Qi

“…Consequently, MDSCs in the TME are key regulators of cancer immune responses and potential therapeutic targets in cancer treatment. …”
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The Interplay Between Viral Infection and Cell Death: A Ping-Pong Effect by Alireza Nourazarian, Hadi Yousefi, Cigir Biray Avci, Behrouz Shademan, Emad Behboudi

“…Programmed cell death (PCD) is a well-studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. …”
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Immune Dysfunction in Tourette Syndrome by Ishraga Elamin, Mark J. Edwards, Davide Martino

“…Genes related to both cell- and antibody-mediated immune responses may be over-expressed at specific ages in youngsters with TS. …”
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Mechanisms of allorecognition and xenorecognition in transplantation by Il Hee Yun, Jaeseok Yang

“…Foreign antigen recognition is the ability of immune cells to distinguish self from nonself, which is crucial for immune responses in both invertebrates and vertebrates. …”
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Exploring the Potential of Postbiotics for Food Safety and Human Health Improvement by Folayemi Janet Isaac-Bamgboye, Chiamaka Linda Mgbechidinma, Helen Onyeaka, Ireoluwa Toluwalase Isaac-Bamgboye, Deborah C. Chukwugozie

“…Findings suggest that postbiotics hold promise for improving health and preservation by inhibiting pathogenic bacteria growth and modulating immune responses.…”
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Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity by Sara Benedé, Leticia Pérez-Rodríguez, David Menchén-Martínez, Elena Molina, Rosina López-Fandiño

“…BackgroundIt is well-documented that house dust mite (HDM) exposure can cause tissue damage and activate innate immune responses. However, its role in promoting gastrointestinal sensitization and allergenicity to food proteins has been relatively unexplored.MethodsThis study investigates the immunostimulatory effects of HDM in a murine model of oral sensitization to egg white (EW) in the absence of exogenous adjuvants. …”
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Modelling Peroxisomal Disorders in Zebrafish by Chenxing S. Jiang, Michael Schrader

“…They have been linked to healthy ageing, neurodegeneration, cancer, the combat of pathogens and viruses, and infection and immune responses. Their biogenesis relies on several peroxins (encoded by <i>PEX</i> genes), which mediate matrix protein import, membrane assembly, and peroxisome multiplication. …”
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Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells by Hiroshi Tanaka, Tadaatsu Imaizumi

“…The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and noninfectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. …”
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Fine-tuning SLE treatment: the potential of selective TYK2 inhibition by Yoshiya Tanaka, Shingo Nakayamada, Yurie Satoh-Kanda

“…Therefore, the modulation of the JAK-STAT pathway has the potential to control immune responses in SLE. Although several JAK/TYK2 inhibitors are currently undergoing clinical trials, more selective drugs that can target cytokine signals according to the specific pathology of the disease are required. …”
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Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine by Devang M. Patel, Jainy Shah, Anand S. Srivastava

“…Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feasible without a substantial risk of immune rejection. …”
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Implication of Fructans in Health: Immunomodulatory and Antioxidant Mechanisms by Elena Franco-Robles, Mercedes G. López

“…However, a more direct mechanism for fructan activity has recently been suggested; fructans may interact with immune cells in the intestinal lumen to modulate immune responses in the body. Fructans are currently being studied for their potential as “ROS scavengers” that benefit intestinal epithelial cells by improving their redox environment. …”
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Regulated microbe vaccines: from concept to (pre-clinical) reduction to practice by Richard Voellmy, David C Bloom, Nuria Vilaboa

“…The RCCVs were found to induce potent anti-herpetic immune responses in mice. Vaccination with RCCVs expressing an influenza virus hemagglutinin broadly protected animals against lethal influenza virus challenges. …”
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Chain Gangs: New Aspects of Hyaluronan Metabolism by Michael Erickson, Robert Stern

“…., the ability to modulate immune responses through effects on T regulatory cells and, in its fragmented forms, by being able to engage several toll-like receptors. …”
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Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients by Y. Kenan Coban, Murat Aral

“…IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. …”
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A Case of Leukocytoclastic Vasculitis and Associated Conjunctivitis Following MMR Vaccine Administration by Hana I. Nazir, Aubrey A. Hess, Abha Soni, Kathryn A. Potter

“…With the COVID-19 pandemic, more adults are receiving the MMR vaccine, as it may enhance innate immune responses against COVID-19 infection. Here, we report a case of LCV and associated conjunctivitis arising in a patient secondary to immunization with the MMR vaccine. …”
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A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice. by Elisa Rossetti, Marija Vujadinovic, Ella van Huizen, Jeroen Tolboom, Hanneke Schuitemaker, Feng Yao, Roland Zahn, Eirikur Saeland

“…Replication-incompetent adenoviral vectors are potent inducers of humoral and cellular immune responses in humans. We have designed an adenoviral vector type 35 (Ad35)-based vaccine encoding the HSV-2 major surface antigen gD2 (Ad35.HSV.gD2). …”
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