The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course by Jessica Mwinyi, Christa Grete-Wenger, Jyrki J. Eloranta, Gerd A. Kullak-Ublick

“…PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. …”
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Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis by Daciana C. Dumut, Daciana C. Dumut, Marian Hajduch, Marian Hajduch, Amanda M. Zacharias, Qingling Duan, Qingling Duan, Ivo Frydrych, Zuzana Rozankova, Zuzana Rozankova, Miroslav Popper, Miroslav Popper, Dusan Garic, Radu Alexandru Paun, Radu Alexandru Paun, Amanda Centorame, Amanda Centorame, Juhi Shah, Martin Mistrik, Martin Mistrik, Petr Dzubak, Petr Dzubak, Juan B. De Sanctis, Juan B. De Sanctis, Danuta Radzioch, Danuta Radzioch, Danuta Radzioch, Danuta Radzioch

“…CuET is shown to convert immunologically inactive tumors into hotbeds of antitumor immune responses, marked by increased lymphocyte infiltration, heightened cytotoxicity of natural killer (NK) and T cells, and enhanced non-self recognition by lymphocytes. …”
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Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor by Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

“…This suggests that adaptive immune responses to spermatogenic cells are not a cause of defective spermatogenesis in Cldn11-deficient mice. …”
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Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma by Hua Ruheng, Yu Pengfei, Zheng Wanting, Wu Nuwa, Yu Wangjianfei, Kong Qingyu, He Jun, Qin Lei

“…It plays a role in modulating inflammatory and immune responses. In this study, we find that Tim-1 is overexpressed in hepatocellular carcinoma (HCC) samples and that its expression is significantly correlated with postoperative survival. …”
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Aptamers: A Feasible Technology in Cancer Immunotherapy by M. M. Soldevilla, H. Villanueva, F. Pastor

“…A variety of aptamers described to date have been shown to be reliable in modulating immune responses against cancer by either blocking or activating immune receptors. …”
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Identification and Characterization of the <i>LecRLKs</i> Gene Family in Maize, and Its Role Under Biotic and Abiotic Stress by Xiangbo Yang, Ziqi Chen, Jianyu Lu, Xuancheng Wei, Yanying Yao, Wendi Lv, Jiarui Han, Jianbo Fei

“…It can rapidly respond to both biotic and abiotic stresses while mediating mechanisms of plant immune responses. This study represents the first identification of the LecRLK family genes in maize. …”
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Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor by Nikolaos Vrachnis, Fotodotis M. Malamas, Stavros Sifakis, Panayiotis Tsikouras, Zoe Iliodromiti

“…The mechanisms related to their effect differ between humans and other species, thus, despite extensive research, many questions remain to be answered regarding their mediation in human labor. Immune responses to progesterone and CRH are important for labor. …”
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GmWRKY33a is a hub gene responsive to brassinosteroid signaling that suppresses nodulation in soybean (Glycine max) by Mingliang Yang, Mingliang Yang, Chengjun Lei, Chengjun Lei, Chao Ma, Chao Ma, Xiuming Hou, Xiuming Hou, Mingming Yao, Mingming Yao, Liang Mi, Liang Mi, Enliang Liu, Linli Xu, Shukun Wang, Shukun Wang, Chunyan Liu, Chunyan Liu, Qingshan Chen, Qingshan Chen, Dawei Xin, Dawei Xin, Chang Xu, Chang Xu, Jinhui Wang, Jinhui Wang

“…The qRT-PCR analysis confirmed that BR signaling upregulates GmWRKY33a, leading to nodulation suppression and activation of soybean immune responses. In summary, our research revealed that BR suppresses root nodule formation by modulating the immune signaling pathway in soybean roots. …”
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Transcriptomics-based investigation of resistance differences to swine fever between large white pigs and min pigs by Jia Li, Deming Ren, Xiangxu Meng, Yiyun He, Lixian Wang, Xihui Sheng, Ligang Wang

“…This heightened immune responsiveness could contribute to the observed differences in disease resistance between Min pigs and Large White pigs.…”
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Probiotics in the Modern World by Y. P. Uspenskiy, Y. A. Fominykh, K. N. Nadzhafova, S. V. Polyushkin

“…Alike normal microflora, probiotic strains incorporate into general metabolism by mediating a spectrum of functions, e.g. maintaining colonisation resistance, nutrient metabolism, supplying the host with vital metabolites, regulation of local and adaptive immune responses, enhancing the intestinal barrier. Probiotics are applied in various diseases associated with general imbalances of the organism. …”
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Secretory Products of Trichinella spiralis Muscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies by Ljiljana Sofronic-Milosavljevic, Natasa Ilic, Elena Pinelli, Alisa Gruden-Movsesijan

“…Those products can successfully modulate parasite-specific immune responses as well as responses to unrelated antigens (either self or nonself in origin), providing an anti-inflammatory milieu and maintaining homeostasis. …”
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Immunogenicity of Pfizer mRNA COVID-19 Vaccination Followed by J&J Adenovirus COVID-19 Vaccination in Two Patients with Chronic Lymphocytic Leukemia by Zoe L. Lyski, Myung Sun Kim, David Xthona Lee, David Sampson, Hans-Peter Raué, Vikram Raghunathan, Debbie Ryan, Amanda E. Brunton, Mark K. Slifka, William B. Messer, Stephen E. Spurgeon

“…SARS-CoV-2 specific immune responses, including antibodies and memory B-cells, CD4 and CD8 T-cells were assessed prior to vaccination, as well as postinitial vaccination series and post-third dose in two subjects. …”
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Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics by Chang Yi Shi, Chen Huan Yu, Wen Ying Yu, Hua Zhong Ying

“…The imbalance of microbiota is usually linked to the aberrant immune responses and inflammation, which eventually promotes the occurrence and development of respiratory diseases. …”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Our study thus highlights the potential application of catalytic nanoparticles as a promising alternative to conventional infection treatment to effectively modulate the innate immune responses and to engineer macrophages for immunotherapy purposes.…”
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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis by Ruyi Zhang, Ruyi Zhang, Ning Ding, Xicui Feng, Wenli Liao

“…Research indicates that gut bacteria produce metabolites, including short-chain fatty acids (SCFAs), which affect mucosal immunity, antigen presentation, and immune responses, thereby influencing cognitive functions. …”
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Sterile osteomyelitis: a cardinal sign of autoinflammation by Tiago Borges, João Santos, Sérgio Silva

“…Autoinflammatory bone disorders (ABDs) are characterized by sterile bone inflammation stemming from dysregulated innate immune responses. This review focuses on the occurrence of sterile osteo­myelitis in ABDs and related diseases, notably chronic nonbacterial osteomyelitis (CNO) and its sporadic and monogenic forms, such as deficiency of the interleukin-1 (IL-1) receptor antagonist, Majeed syndrome, CNO related to FBLIM1 mutation, and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome). …”
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Baseline gene expression in BALB/c and C57BL/6 peritoneal macrophages influences but does not dictate their functional phenotypes by Carlos M. Restrepo, Carlos M. Restrepo, Alejandro Llanes, Alejandro Llanes, Lizzi Herrera, Esteban Ellis, Esteban Ellis, Esteban Ellis, Iliana Quintero, Patricia L. Fernández, Patricia L. Fernández

“…Macrophages are effector cells of the immune system and essential modulators of immune responses. Different functional phenotypes of macrophages with specific roles in the response to stimuli have been described. …”
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Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARα by Bianca Knoch, Matthew P. G. Barnett, Janine Cooney, Warren C. McNabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul MacLean, Scott O. Knowles, Nicole C. Roy

“…Innate and adaptive immune responses showed differences in gene expression relating to colitis severity. …”
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Unraveling the Molecular Mechanisms of Mosquito Salivary Proteins: New Frontiers in Disease Transmission and Control by Jiayin Guo, Xiaoe He, Jianli Tao, Hui Sun, Jing Yang

“…Specific mosquito salivary proteins (MSPs) can promote pathogen transmission through mechanisms that either regulate hosts’ anti-infective immune responses or directly enhance pathogens’ activity. …”
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Commensal bacteria education history calibrates the naivety and activation threshold of adaptive antiviral immune system by Baohua Li, Zhou Sha, Li Mou, Feng Zhang, Lifeng Jia, Yan Zhu, Yan Guo, Guohong Deng, Haibo Wu, Hong Wei, Yuzhang Wu, Lilin Ye, Changjiang Liu, Jian Li, Yanyan Zhang, Yanyan Zhang, Yanyan Zhang

“…Here, by employing the naive immune system of germ-free (GF) mice without a history of microbial exposure, we compared their adaptive immune responses with those of the conventional (Conv) mice upon new viral infection. …”
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