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2061
Psychiatric presentation in Rasmussen’s encephalitis
Published 2024-12-01“…Psychiatric manifestations in RE are often attributed to seizure activity and immune responses. RE presents a complex clinical picture with both neurological and psychiatric manifestations. …”
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2062
Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier
Published 2025-02-01“…The interaction between cancer-associated fibroblasts (CAFs) and TME influences immune responses, including resistance to immunotherapy. …”
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2063
Skin Immune Landscape: Inside and Outside the Organism
Published 2017-01-01“…This review aims at providing basic background information on the cutaneous immune system from major cellular and molecular players and the impact of its microbiota on the well-coordinated immune responses in host defense.…”
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2064
The effects of the ketone body ?-hydroxybutyrate on the neuronal transcriptome
Published 2025-02-01“…Our results suggest that under normal conditions, BHBs primary actions include modulation of cellular neuronal immune responses. …”
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2065
Pain Neuroscience Education for Acute Pain
Published 2024-06-01“…However, modern pain science has illuminated the complexity of the human pain experience, incorporating psychosocial elements, nervous system sensitization, immune responses, and structural changes in the brain as factors. …”
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2066
The Role of Intracellular Organisms in the Pathogenesis of Inflammatory Arthritis
Published 2014-01-01“…Interest has, therefore, turned to host-pathogen interactions and whether aberrant immune responses to these could explain the development of arthritis. …”
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2067
Cross-Talk between Apolipoprotein E and Cytokines
Published 2011-01-01“…Moreover, apoE modulates inflammatory and immune responses in an isoform-dependent manner. Correspondingly, inflammatory cytokines can either upregulate or downregulate the production of apoE in various tissue types. …”
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2068
Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics
Published 2024-11-01“…Abstract Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated immune responses. However, within the tumor environment, excessive ICP activation weakens antitumor immunity. …”
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2069
ULACNet-301, OPTIMO protocol: optimizing HPV vaccination regimen for cancer prevention in children and adolescents living with HIV
Published 2025-01-01“…Prior studies among individuals without HIV suggest that a single HPV vaccine dose induces humoral immune responses that, while lower than those induced by two or three doses, still confer protection against HPV infection. …”
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2070
De novo design of protein minibinder agonists of TLR3
Published 2025-01-01“…Abstract Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). …”
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2071
Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment
Published 2014-01-01“…These features endow chemokines with crucial roles in immune responses. Furthermore, increasing evidence points to the vital effects of several chemokines on the proliferative and invasive properties of cancer cells. …”
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2072
Effect of dietary Cucurbita pepo extract on performance, hemato-immunological parameters, immune-related gene expression and bacterial resistance in rainbow trout, Oncorhynchus myk...
Published 2025-06-01“…The aim of this research was to investigate the effects of Cucurbita pepo extract (CPE) on performance, blood parameters, immune responses, expression of immunity-related gene, and disease resistance in rainbow trout. …”
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2073
Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species
Published 2025-01-01“…More importantly, ZnPP@FQOS is verified to enable the stimulation of enhanced immune responses and systemic immunity. This strategy remarkably potentiates the efficacy of photodynamic-immunotherapy, thus providing a promising enlightenment for tumor therapy.…”
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2074
Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models
Published 2015-01-01“…Virus infections represent complex biological systems governed by multiple-level regulatory processes of virus replication and host immune responses. Understanding of the infection means an ability to predict the systems behaviour under various conditions. …”
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2075
CD109, a master regulator of inflammatory responses
Published 2025-02-01“…CD109 modulates TGF-β and NF-κB pathways, to influence immune responses and inflammation. CD109’s multifaceted role in inflammation spans various tissue types, including the skin, lung, bone and bone-related tissues, and various types of cancers. …”
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2076
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Published 2025-01-01“…Abstract Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls. …”
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2077
A pair of promising immune checkpoints PSGL-1 and VISTA from immunotolerance to immunotherapy
Published 2024-12-01“…Abstract Immune checkpoints are crucial for regulating immune responses and maintaining self-tolerance, as they play a pivotal role in preventing autoimmunity and facilitating tumor immune evasion. …”
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2078
Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies
Published 2025-01-01“…<b>Results</b>: Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. <b>Conclusions</b>: Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention.…”
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2079
Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis
Published 2024-12-01“…For the unique PCV15 serotypes, 22F and 33F, immune responses were higher in infants and adults vaccinated with PCV15 compared to those receiving PCV13. …”
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2080
NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness
Published 2018-01-01“…Injection of either AQP4 peptide or NMO-Ig to EAMG or to naive mice caused increased fatigability and aggravation of EAMG symptoms as expressed by augmented muscle weakness (but not paralysis), decremental response to repetitive nerve stimulation, increased neuromuscular jitter, and aberration of immune responses. Thus, our study shows increased disease severity in EAMG mice following immunization with the NMO autoantigen AQP4 or by NMO-Ig, mediated by augmented inflammatory response. …”
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