Case Report: The importance of genetic counseling for families with hyperinsulinism by Victoria R. Sanders, Victoria R. Sanders, Katherine Lord, Katherine Lord, Katherine Lord, Winnie M. Sigal, Winnie M. Sigal, Winnie M. Sigal, Heather McKnight, Heather McKnight, N. Scott Adzick, N. Scott Adzick, Lisa J. States, Lisa J. States, Tricia Bhatti, Tricia Bhatti, Diva D. De Leon, Diva D. De Leon, Diva D. De Leon

“…Understanding the genetic etiology also allows accurate genetic counseling to be provided, illustrated by two families following a diagnosis of HI. …”
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The Influence of the Motor Traction Vibration on Fatigue Life of the Bogie Frame of the Metro Vehicle by Qiushi Wang, Jinsong Zhou, Dao Gong, Tengfei Wang, Jiangxue Chen, Taiwen You, Zhanfei Zhang

“…Some individual loads, such as motor vibration, have been ignored or wrongly understood, which leads to the occurrence of local insufficient fatigue life of the frame. To illustrate the influence of the motor vibration on the fatigue life of the bogie frame, a metro vehicle was taken as an example: first, the precise finite element model of the frame was established, and its correctness was verified; then, the vibration characteristics of the frame were analyzed by sweep frequency calculation; and finally, considering the vibration acceleration signal of the motor measured on a metro line as the excitation, the influence of the random vibration on the fatigue life of the frame under traction and idle running conditions was compared and analyzed by solving the power spectral density of the dynamic stress response at the weak fatigue nodes of the structure. …”
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Creating visualizations using generative AI to guide decision-making in street designs: A viewpoint by Gabriel Valença, Carlos Azevedo, Filipe Moura, Ana Morais de Sá

“…Architecture software tools are usually used to illustrate new street design layouts (e.g., Computer-Aided Design). …”
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The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure by Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Jianping Zhu, Xun Wang

“…In most treatments, the results showed that both behavior strength and AChE activity stayed in the same field within a correlation circle. These results illustrated that the environmental stress caused by both DM and MT could inhibit AChE activity and subsequently induce a stepwise behavior response, though both pesticides affect it as direct and indirect inhibitors, respectively.…”
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Implications of entropy generation in bioconvective flow on Maxwell nanofluid past a Riga plate with Cattaneo--Christov model by K. Loganathan, Prasun Choudhary, S. Eswaramoorthi, K. Senthilvadivu, N. Thamaraikannan, Reema Jain

“…The derived system of ordinary differential equations is resolved utilizing convergent series solution via an analytical method known as the homotopy analysis method (HAM). The graphs illustrate the impact of several physical parameters on flow profiles, emphasizing their unique properties. …”
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Fast dynamical simulation combining harmonic-modal hybrid formulations with space separated representations by Claudia Germoso, Sebastian Rodriguez, Angelo Pasquale, Francisco Chinesta

“…The primary contribution of this work lies in coupling harmonic-modal analysis with space-separated representations, combining the strengths of these methods.The performance and versatility of the proposed approach are demonstrated through the resolution of three illustrative problems: a 3D thermal analysis of a thin plate, a laminated plate, and a 3D elastodynamic analysis of a plate. …”
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Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment by Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

“…Compared to untreated SMSC-EXOs, Sr-pretreated SMSC-derived exosomes (Sr-SMSC-EXOs) demonstrated superior therapeutic efficacy by mitigating chondrocyte ferroptosis and reducing osteoclast-mediated joint pain in TMJOA. Our results illustrate Alix’s crucial role in Sr-triggered miRNA loading, identifying miR-143-3p as a key anti-TMJOA exosomal component. …”
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Variability in storm season intensity modulates ocean acidification conditions in the northern Strait of Georgia by Wiley Evans, Katie Campbell, Carrie Weekes, Justin Del Bel Belluz, Jessy Barrette, Drew Jordison, Chris Mackenzie, Jonathan Bergshoeff, Carolyn Prentice, Rosie Savage, Isabelle Desmarais, Bryn Fedje, Emma Myers, Kimberly Bedard, Alex Hare, Ian J. W. Giesbrecht, Colleen T. E. Kellogg, Zoe Sandwith, Jennifer M. Jackson

“…This sensitivity to the storm season intensity highlights how vulnerable the northern Strait of Georgia is to subtle changes in environmental forcing and provides some predictive capacity for OA conditions over the coming year. These results illustrate that OA is not a “slow burn” process within weakly-buffered settings, but rather invokes periods of intensification with poorly understood biological implications.…”
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Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells by Chaoqun Huang, Wei Liu, Xiaochuan Zhao, Libin Zhao, Fuxiang Wang

“…In summary, our data illustrate that inhibition of HBx effectively suppressed proliferation and metastasis and induced apoptosis of liver cancer cells, which might be partially reversed by XB130. …”
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Microscopic stress-constrained two-scale topology optimisation for additive manufacturing by Xiaopeng Zhang, Zheng Ni, Akihiro Takezawa, Yaguang Wang, Zhan Kang

“…Numerical examples illustrate the effect of the stress constraints by comparing the optimisation results with and without microscopic stress constraints. …”
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Cuckoo Search with Lévy Flights for Weighted Bayesian Energy Functional Optimization in Global-Support Curve Data Fitting by Akemi Gálvez, Andrés Iglesias, Luis Cabellos

“…To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. …”
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Strengthened 32‐bit AES implementation: Architectural error correction configuration with a new voting scheme by Saeideh Sheikhpur, Mahdi Taheri, Mohammad Saeed Ansari, Ali Mahani

“…In this paper, a reliable and secure 32‐bit data‐path AES implementation based on our robust fault resilient approach is developed. We illustrate that the proposed architecture can tolerate up to triple‐bit (byte) simultaneous faults at each pipeline stage’s logic and verify our claim through extensive error simulations. …”
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Polarization Scattering Regions: A Useful Tool for Polarization Characteristic Description by Jiankai Huang, Jiapeng Yin, Zhiming Xu, Yongzhen Li

“…The research leverages Cameron decomposition to reveal the distinctive scattering behaviors within each region, illustrating that at higher-frequency bands, scattering approximates spherical symmetry, with minimal impact from the target shape. …”
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Sinus Venosus Atrial Septal Defect Complicated by Eisenmenger Syndrome and the Role of Vasodilator Therapy by Amornpol Anuwatworn, Maheedhar Gedela, Edgard Bendaly, Julia A. Prescott-Focht, Jimmy Yee, Richard Clark, Orvar Jonsson

“…We also observed progressive reversal of the right-to-left shunt. This case illustrates the potential benefit of vasodilator therapy in reversing Eisenmenger physiology, which may lead to surgical repair of the atrial septal defect as the primary treatment.…”
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Targeting MAO-B with Small-Molecule Inhibitors: A Decade of Advances in Anticancer Research (2012–2024) by Iyman Alsaad, Diana M. A. Abdel Rahman, Ola Al-Tamimi, Shayma’a A. Alhaj, Dima A. Sabbah, Rima Hajjo, Sanaa K. Bardaweel

“…Further molecular modeling analysis illustrated the basis of MAO-B ligand binding, revealing a hydrophobic binding pocket, with key residues such as Tyr398 and Tyr435 playing crucial roles in substrate oxidation. …”
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Optimization of dark chocolate formulation with roasted coriander cake as cocoa substitute by Javad Cheragheshahi, Ali Mohamadi Sani, Elham Mahdian, Sharareh Mohseni, Zahra Nazari

“…According to the results, the fitted models illustrated a desirable coefficient of determination (≥90 %).The optimization of the variables indicated that using RCC 6.08 g, Sugar 14.68 g, and Cocoa 12.23 g produced the optimized RCC chocolate with the highest desirability while maintaining the quality characteristics without undesirable changes. …”
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Research prospects for kidney xenotransplantation: a bibliometric analysis by Shujun Yang, Mingtao Zhang, Hao Wei, Bin Zhang, Jiang Peng, Panfeng Shang, Shengkun Sun

“…High-frequency keywords illustrated the current state of development and future trends in xenotransplantation. …”
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Long read Nanopore sequencing identifies precise breakpoints of a de novo paracentric inversion that disrupt the MEIS2 gene in a Chinese girl with syndromic developmental delay by Jianxin Tan, Mingtao Huang, Xiuqing Ji, An Liu, Fengchang Qiao, Cuiping Zhang, Lulu Meng, Yan Wang, Zhengfeng Xu, Ping Hu

“…Our data not only expand the clinical spectrum of MEIS2-caused syndromic developmental delay, but also illustrate the value of long-read sequencing in elucidating the precise genetic etiology of patients with relatively nonspecific clinical findings and chromosomal inversion that are beyond the resolution of conventional approaches.…”
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IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

“…Overall, the evolving drug repurposing landscape illustrates a significant shift in the rationale for schizophrenia drug development, highlighting the potential of in silico strategies, biomarker-based patient stratification, and personalized treatments that align with underlying pathophysiological processes.…”
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Snoezelen or Controlled Multisensory Stimulation. Treatment Aspects from Israel by Joav Merrick, Carmit Cahana, Meir Lotan, Isack Kandel, Eli Carmeli

“…This paper presents the concept illustrated with two case stories.…”
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