Timely short-term specialised palliative home care for older people with frailty and their family: a mixed-methods pilot randomised controlled trial and process evaluation by Lieve Van den Block, Kim de Nooijer, Lara Pivodic, Peter Pype, Nele Van Den Noortgate, Rose Miranda, Kim Eecloo, Stefanie De Buyser, Aurelie Joos, Katlijn Van Mulders

“…The baseline mean score on the five palliative care symptoms was 6.0 and 5.6 in intervention and control group, respectively; and 4.5 and 4.1 at 8 weeks (adjusted ratio 1.0, ie, no effects on symptoms).Conclusions While Frailty+ was generally welcomed by older people with frailty, families and palliative care nurses, our process evaluation uncovered multiple barriers, mostly rooted in the current organisation of specialised palliative care that is tailored to advanced stages of illness. Ensuring timely access requires efforts beyond timely referral alone, and implies profound organisational and cultural change.Trial registration number ISRCTN39282347.…”
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Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management by Bhargav Shreevatsa, Bhargav Shreevatsa, Abhigna Nagaraj, Chandan Dharmashekar, Anisha Jain, Bhavana Harendra, Siddesh V. Siddalingegowda, Haneen A. Al-Mazroua, Sheikh F. Ahmad, Shashanka K. Prasad, Chandrashekar Srinivasa, Chandan Shivamallu, Shiva Prasad Kollur

“…Multiple sclerosis (MS) is a chronic autoimmune illness characterized by demyelination, neurodegeneration, and inflammation in the central nervous system. …”
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Guillain-Barré syndrome following falciparum malaria infection: a case report by Molla Asnake Kebede, Alemayehu Beharu Tekle, Misikir Alemu Eshetu, Erkyehun Pawlos Shash, Melaku Tsediew Berhanu, Elias Tabiet Ahmed, Hashime Meketa Negatie

“…Discussion Guillain-Barré Syndrome (GBS) is an acute paralytic illness often triggered by infections, particularly viral ones. …”
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Histological staining of tick bite skin biopsies for spirochetes and Powassan virus RNA by Jihane Oufattole, Anne Piantadosi, Sam R. Telford, Alvaro C. Laga, Isaac H. Solomon

“…Examination of skin biopsies using similar tools may prove valuable in studying the pathogenesis of diseases, such as southern tick-associated rash illness, for which a causative pathogen has not yet been identified.…”
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Prevalence of gastrointestinal symptoms after recovery from COVID-19: A questionnaire-based study in the Aseer region by Mohammed Attieh Alzahrani, Khalid Siraj Altalhiyyah, Mohammed Mousa Albariqi, Meshal Ali Alkhayri, Saad Ali Alshahrani, Sultan Saad Alnasser, Nawaf Mohammed Alshehri, Saad Haif Alqahtani, Saud Haif Alqahtani

“…Background: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide, and although it is primarily a respiratory illness, gastrointestinal symptoms have been reported in a significant proportion of patients. …”
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A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India by Sayani Bose, Feradica D Laloo, Partha Pratim Maity, Anirban Bhaduri

“…Background: Dengue virus (DENV) which is endemic in many tropical and subtropical areas around the world has four serotypes (DENV1, DENV2, DENV3and DENV4), this viral infection can either cause mild febrile illness Dengue fever or severe, such as Dengue hemorrhagic fever or Dengue Shock Syndrome. …”
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Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1 by Daiana Alvarez-Olmedo, Claire Kamaliddin, Theodore B. Verhey, May Ho, Rebekah De Vinney, George Chaconas

“…It is the most common tick-transmitted illness in the Northern Hemisphere. The ability of this pathogen to spread to a wide variety of locations results in a diverse set of clinical manifestations, yet little is known regarding vascular escape of the spirochete, an important pathway for dissemination. …”
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Ethnic inequalities in mental and physical multimorbidity in women of reproductive age: a data linkage cohort study by Amelia Jewell, Matthew Broadbent, Stephani Hatch, Mark Ashworth, Megan Pritchard, Sarah Dorrington, Louise Howard, Raquel Catalao

“…Objectives Explore inequalities in risk factors, mental and physical health morbidity in non-pregnant women of reproductive age in contact with mental health services and how these vary per ethnicity.Design Retrospective cohort study.Setting Data from Lambeth DataNet, anonymised primary care records of this ethnically diverse London borough, linked to anonymised electronic mental health records (‘CRIS secondary care database’).Participants Women aged 15–40 years with an episode of secondary mental health care between January 2008 and December 2018 and no antenatal or postnatal Read codes (n=3817) and a 4:1 age-matched comparison cohort (n=14 532).Main outcome measures Preconception risk factors including low/high body mass index, smoking, alcohol, substance misuse, micronutrient deficiencies and physical diagnoses.Results Women in contact with mental health services (whether with or without severe mental illness (SMI)) had a higher prevalence of all risk factors and physical health diagnoses studied. …”
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Diagnosis of lung cancer using salivary miRNAs expression and clinical characteristics by Negar Alizadeh, Hoda Zahedi, Maryam Koopaie, Mahnaz Fatahzadeh, Reza Mousavi, Sajad Kolahdooz

“…Abstract Objective Lung cancer (LC), the primary cause for cancer-related death globally is a diverse illness with various characteristics. Saliva is a readily available biofluid and a rich source of miRNA. …”
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A persona-based exploration of rabies post-exposure prophylaxis seeking behavior and its implication for communication strategic planning: Evidence from Thailand by Jitjayang Yamabhai, Patoo Cusripituck, Teerawan Mingbualuang, Nareerat Sangkachai, Wimwiga Sakchainanon, Chanatda Tungwongjulaniam, Onphirul Yurachai, Ratana Theerawat, Anuwat Wiratsudakul

“…Rabies is a lethal zoonotic illness that claims over 59,000 lives annually. However, this fatality can be avoided by postexposure prophylaxis (PEP). …”
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Factors Leading to Malnutrition in Children Under Five Years in Nyamwamba Division, Kasese Municipality, Kasese District. by Kabugho, Mary Consolata

“…Malnutrition is regarded as the most important risk factor for illness and death globally and it is associated with 52.5% 0f all deaths in young children (Lisanu Mazengia & Andargie Biks, 2018). …”
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Factors Associated with Stunting in Children Under Five Years of Age: A Case of Buhara Sub County, Kabale District. by Namanya, Oliver

“…The study made the following findings in line with the objectives: low household income, child illness in the last few weeks incomplete child vaccination (p- Value = 0.005 < 0.05 and p- value = 0.001 < 0.05), the child’s guardian ethnicity with (p- value = 0.013 < 0.05 and 0.000), open defecation, indiscriminate waste disposal, 18(4.7%) 95 CI= 028311725 - .073831273) and use of unprotected water sources, were the major factors associated with stunting. …”
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Refractory myasthenia gravis treated with autologous hematopoietic stem cell transplantation by Benjamin Beland, Jan Storek, Liam Quartermain, Christopher Hahn, C. Elizabeth Pringle, Pierre R. Bourque, Michael Kennah, Natasha Kekre, Christopher Bredeson, David Allan, Kareem Jamani, Christopher White, Harold Atkins

“…Three patients were not evaluable for the primary outcome: one due to confounding illness and two died within 12 months of transplant. …”
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Poor sleep quality and associated factors among HIV-positive and negative postpartum women in Addis Ababa, Ethiopia: a comparative cross-sectional study by Milen Mihertabe, Alehegn Bishaw Geremew, Alehegn Bishaw Geremew, Elsa Awoke Fentie, Gidey Rtbey

“…Being HIV-positive [AOR = 2.38, 95% CI (1.31, 4.32)], being divorced [AOR = 4.5, 95% CI (1.55, 13)], and having a family history of mental illness [AOR = 1.89, 95% CI (1.16, 3.1)], depression [AOR = 1.93 (1.11, 3.3)], and anxiety [AOR = 2.76, 95% CI (1.8, 4.2)] among postpartum women and poor social support [AOR = 6, 95% CI (1.63, 22.4)] among HIV-positive women were significantly associated with poor sleep quality.Conclusion and recommendationThis study revealed that the prevalence of poor sleep quality was higher among HIV-positive postpartum women compared to HIV-negative women. …”
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Sistem Pendeteksi Central Sleep Apnea Menggunakan Metode Neural Network dengan Fitur RR Interval dan Durasi QRS by Dittha Ratanasari, Edita Rosana Widasari, Rizal Maulana

“…The goal of this study was to create a portable device for detecting CSA illness. It has been evaluated to help in the diagnosing process and uses cardiac ECG data since the heart rhythms alter during periods of abrupt stoppage during sleep. …”
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Beliefs in Good and Bad Days among the Tatars in Dobrudja and Among the Polish-Lithuanian Tatars (Preliminary Remarks) by Veneta Yankova

“…An attempt was made to systematize the permitted and unacceptable activities on certain days related to agriculture, family, wedding, childbirth, travel, illness, dreams, etc. By means of their comparative analysis, the manifestations of the so-called folk (popular) Islam, the connection with the common Turkic and all-Islamic heritage are revealed, the role of the contexts of the Balkan and Baltic cultures is outlined. …”
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Anxiety disorders and the gut microbiota: a bibliometric and visual analysis by Linli Guo, Linli Guo, Qin Ding, Qin Ding, Qing Li, Danping Zheng, Danping Zheng, Linglin Guo, Linglin Guo, Xiaotao Cao, Xiaotao Cao, Qianqian Mou, Qianqian Mou

“…IntroductionAnxiety disorder is a common mental illness, yet its specific mechanisms remain unclear. …”
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Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support by Tae Higuchi, Tomomi Ide, Takeo Fujino, Takeshi Tohyama, Yuta Nagatomi, Tomoyuki Nezu, Masataka Ikeda, Toru Hashimoto, Shouji Matsushima, Keisuke Shinohara, Masaaki Nishihara, Takeshi Iyonaga, Tomohiko Akahoshi, Tomoki Ushijima, Akira Shiose, Shintaro Kinugawa, Hiroyuki Tsutsui, Kohtaro Abe

“…Abstract Intensive care unit-acquired weakness (ICU-AW) is recognized as newly-acquired bilateral muscle weakness, which is a complication of critical illness in the ICU; however, there are no reports on the pathogenesis and early predictors of ICU-AW specifically associated with cardiogenic shock (CS). …”
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Treatment Options for Psychotic Depression in Adolescents: A Comprehensive Review by Perez-Rodriguez V, Aymerich C, Catalan A, Jauhar S, Salazar de Pablo G

“…Centro de Investigación En Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barakaldo, Bizkaia, Spain; 4Centre for Affective Disorders, Psychological Medicine, Ioppn, King’s College, London, UK; 5Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust, London, UK; 6Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, Iisgm, CIBERSAM, Madrid, SpainCorrespondence: Dr Gonzalo Salazar de Pablo, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience (IoPPN) King’s College London, Room D1.14, Child Psychiatry Building 16 De Crespigny Park, London, SE5 8AB, United Kingdom, Tel +44 0207 848 0002, Email gonzalo.salazar_de_pablo@kcl.ac.ukAbstract: Despite being associated with increased illness severity and suicidality compared to non-psychotic depression, psychotic depression remains under-researched, particularly in adolescents. …”
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ViT-Based Face Diagnosis Images Analysis for Schizophrenia Detection by Huilin Liu, Runmin Cao, Songze Li, Yifan Wang, Xiaohan Zhang, Hua Xu, Xirong Sun, Lijuan Wang, Peng Qian, Zhumei Sun, Kai Gao, Fufeng Li

“…It not only opens a new path for SZ detection but also brings new tools and concepts to the research and application in the field of mental illness.…”
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