Modeling the endocrine control of vitellogenin production in female rainbow trout by Kaitlin Sundling, Gheorghe Craciun, Irvin Schultz, Sharon Hook, James Nagler, Tim Cavileer, Joseph Verducci, Yushi Liu, Jonghan Kim, William Hayton

“…This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fish species.We present a model of Vg production in female rainbowtrout which incorporates a biological pathway beginningwith sex steroid estradiol-17β levels in the plasma andconcluding with Vg secretion by the liver and sequestration in theoocytes. …”
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Integration of bulk and single-cell RNA-seq reveals prognostic gene signatures in patients with bladder cancer treated with immune checkpoint inhibitors by Mina Cho, Hyun Chang, Ju Han Kim

“…We used two independent datasets to validate the BC-GS. …”
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Exploring the protective role of caffeine against Taraxacum-Induced ribotoxic stress mediated through autophagy and mitochondrial depolarization by Chien-Jung Lin, Shu-Ting Liu, Zih-Syuan Wu, Shih-Ming Huang, Teng-Wei Chen

“…Taraxacum can induce apoptosis-associated ribosomal RNA (rRNA) cleavage, however, the exact working mechanism of Taraxacum-induced rRNA cleavage remains unclear. In this study, we used the RNA integrity (RIN) value and 28S/18S ratio to confirm the integrity of experiments. …”
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Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population by Zoi Zagoriti, Marianthi Georgitsi, Olga Giannakopoulou, Fotios Ntellos, Socrates J. Tzartos, George P. Patrinos, Konstantinos Poulas

“…We focused on three candidate genes which have been clearly associated with several autoimmune diseases, aiming to investigate their potential implication in MG pathogenesis. …”
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The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity by Zahava Vadasz, Regina Peri, Nasren Eiza, Gleb Slobodin, Alexandra Balbir-Gurman, Elias Toubi

“…Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. …”
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Characterizing the Crosstalk of NCAPG with Tumor Microenvironment and Tumor Stemness in Stomach Adenocarcinoma by Zheng Xiang, Genlan Cha, Yihao Wang, Jikai Gao, Jianguang Jia

“…However, its biological roles in tumorigenesis and metastasis remain unclear. Thus, we aimed to assess the prognostic utility of NCAPG in stomach adenocarcinoma (STAD) and its potential as a tumor biomarker. …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…Furthermore, we demonstrate that a similar masking strategy can be used to create a pro-drug form of the frequently used anti-CD3 antibody SP34. …”
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Integrated treatment of depression and moderate to severe alcohol use disorder in women shows promise in routine alcohol use disorder care – a pilot study by Anna Persson, Anna Persson, Daniel Wallhed Finn, Alice Broberg, Amanda Westerberg, Åsa Magnusson, Åsa Magnusson, Olof Molander

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Exploring the potential impact of the proposed UK TV and online food advertising regulations: a concept mapping study by Jean Adams, Martin White, Peter Scarborough, Richard Smith, Emma J Boyland, Hannah Forde

“…To guide the regulations’ implementation and evaluation, we aimed to develop a concept map to hypothesise their potential consequences for the commercial food system, health and society.Methods We used adapted group concept mapping in four virtual workshops with food marketing and regulation experts across academia, civil society, government organisations, and industry (n=14), supported by Miro software. …”
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Field apple scab susceptibility of a diverse Malus germplasm collection identifies potential sources of resistance for apple breeding by David Papp, Liqiang Gao, Ranjita Thapa, Dan Olmstead, Awais Khan

“…Results We found that ~ 37% of the wild Malus accessions and domesticated cultivars were resistant to apple scab in the field. …”
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Effects of age and diet on triglyceride metabolism in mice by Kathryn M. Spitler, Shwetha K. Shetty, Brandon S.J. Davies

“…We measured survival, body composition, plasma triglyceride levels, chylomicron clearance, and oral fat, glucose, and insulin tolerance. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…In this study, we identify the core genes promoting transcription and expression following T2943-mediated upregulation of H3K14ac, highlighting Grid1 (GluD1) as a central gene. …”
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Higher-dimensional Willmore energy as holographic entanglement entropy by Giorgos Anastasiou, Ignacio J. Araya, Pablo Bueno, Javier Moreno, Rodrigo Olea, Alejandro Vilar Lopez

“…Rather, F(A) can take arbitrarily positive and negative values as a function of A. Hence, we conclude that the round ball is not a global minimizer of F(A) for general five-dimensional CFTs.…”
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Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets by Xin Niu, Lei Zhang, Yuchen Wu, Zhi Zong, Bin Wang, Jisheng Liu, Long Zhang, Fangfang Zhou

“…Moreover, we reviewed the functions of condensates and therapeutic targets for diseases. …”
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An Intriguing Case of Multisystem Inflammatory Syndrome in an Adult Patient with Remote Infection with COVID-19 and Acute Chlamydia by Madhuri Chandnani, William A. Charini, Anil Jha, Chetan Dodhia, Eduardo Haddad

“…Conclusion. We present a case of an adult patient with acute Chlamydia trachomatis infection occurring in the wake of asymptomatic (or at least unrecognized) COVID-19 resulting in MIS-A. …”
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Chemical Chaperone of Endoplasmic Reticulum Stress Inhibits Epithelial-Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium via the c-Src Pathway by Heung-Man Lee, Ju-Hyung Kang, Jae-Min Shin, Seoung-Ae Lee, Il-Ho Park

“…EMT is considered as a therapeutic target for several persistent inflammatory airway diseases related to tissue remodeling. Herein, we investigated the role of endoplasmic reticulum (ER) stress and c-Src in TGF-β1-induced EMT. …”
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Electro-optic cavities for in-situ measurement of cavity fields by Michael S. Spencer, Joanna M. Urban, Maximilian Frenzel, Niclas S. Mueller, Olga Minakova, Martin Wolf, Alexander Paarmann, Sebastian F. Maehrlein

“…We thereby demonstrate quantitative retrieval of the cavity modes in amplitude and phase, over a broad THz frequency range. …”
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Persistent Polyclonal B Cell Lymphocytosis B Cells Can Be Activated through CD40-CD154 Interaction by Emmanuelle Dugas-Bourdages, Sonia Néron, Annie Roy, André Darveau, Robert Delage

“…We found that the proliferation of PPBL B cells was almost as important as that of B cells from normal controls, resulting in high immunoglobulin secretion with in vitro isotypic switching. …”
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Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro by Imran H. Chowdhury, Hema P. Narra, Abha Sahni, Kamil Khanipov, Casey L. C. Schroeder, Jignesh Patel, Yuriy Fofanov, Sanjeev K. Sahni

“…We have identified a total of 10,781 and 8310 lncRNA transcripts displaying either positive or negative regulation of expression, respectively, at 3 and 24 h posttreatment. …”
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Modeling BK Virus Infection in Renal Transplant Recipients by Nicholas Myers, Dana Droz, Bruce W. Rogers, Hien Tran, Kevin B. Flores, Cliburn Chan, Stuart J. Knechtle, Annette M. Jackson, Xunrong Luo, Eileen T. Chambers, Janice M. McCarthy

“…We calibrate our model using newly available patient data and a detailed sensitivity analysis. …”
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