Two Unrelated Iranian Patients with Adenosine Deaminase 2 Deficiency: A Case Report and Review of Treatment by Parvaneh Karimzade, Aziz Eghbali, Mohammad Keramatipour, Reza Shiari, Zahra Golchehre, Mahdieh Taghizadeh, Mazdak Fallahi, Shahrzad Fallah, Nasrin Khakbazan Fard, Narges Eslami, Narges Bazgir, Mahnaz Jamee, Zahra Chavoshzadeh

“…Case Presentation. In this case report, we present the clinical and immunological findings of two unrelated patients with DADA2. …”
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CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…Background Despite significant progress in the development of T cell-engaging therapies for various B-cell malignancies, a high medical need remains for the refractory disease setting, often characterized by suboptimal target levels.Methods To address this issue, we have developed a 65-kDa multispecific antibody construct, CLN-978, with affinities tuned to optimize the killing of low-CD19 expressing tumor cells. …”
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Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age by Rumi Katashima, Mari Matsumoto, Yuka Watanabe, Maki Moritani, Ichiro Yokota

“…We also detected a whole exon deletion in the HNF1β gene and an exon 5–6 aberration in the GCK gene, each in one proband (4.4%). …”
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Deciphering the dose-dependent effects of thymoquinone on cellular proliferation and transcriptomic changes in A172 glioblastoma cells. by Rachana Pandey, Purushothaman Natarajan, Umesh K Reddy, Wei Du, Cristian Sirbu, Moussa Sissoko, Gerald R Hankins

“…We confirmed their expression levels through quantitative RT-PCR and performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for these DEGs. …”
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Rapid Hip Osteoarthritis Development in a Patient with Anterior Acetabular Cyst with Sagittal Alignment Change by Yasuhiro Homma, Tomonori Baba, Nobuhiko Sumiyoshi, Hironori Ochi, Hideo Kobayashi, Mikio Matsumoto, Takahito Yuasa, Kazuo Kaneko

“…We thought that the increased posterior tilt of the pelvis after THA reinforced the stress concentration at pre-existed anterior acetabular cyst, thereby the destruction of the cyst was occurred. …”
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Fetuin-B and oxidative stress disrupt placental trophoblasts during maternal undernourishment by Mia Camilliere, Marella R. Verde, Michael S. Wolin, May M. Rabadi, Brian B. Ratliff

“…We examined the MUN placentas and the downstream effects of fetuin-B and oxidative stress at the whole organ and trophoblast levels. …”
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PURE: a Prompt-based framework with dynamic Update mechanism for educational Relation Extraction by Xiaohui Cui, Yu Yang, Dongmei Li, Jinman Cui, Xiaolong Qu, Chao Song, Haoran Liu, Siyuan Ke

“…To address these issues, we propose a Prompt-based framework with dynamic Update mechanism for educational Relation Extraction (PURE). …”
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Identification of TTLL8, POTEE, and PKMYT1 as immunogenic cancer-associated antigens and potential immunotherapy targets in ovarian cancer by Esen Yonca Bassoy, Remya Raja, Thomas E. Rubino, Fabian Coscia, Krista Goergen, Paul Magtibay, Kristina Butler, Alessandra Schmitt, Ann L. Oberg, Marion Curtis

“…From this dataset, we identified TTLL8, POTEE, and PKMYT1 peptides as candidate tumor antigens with low expression in normal tissues and upregulated expression in OC. …”
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Classification of schizophrenia, bipolar disorder and major depressive disorder with comorbid traits and deep learning algorithms by Xiangning Chen, Yimei Lu, Joan Manuel Cue, Mira V. Han, Vishwajit L. Nimgaonkar, Daniel R. Weinberger, Shizhong Han, Zhongming Zhao, Jingchun Chen

“…We found that combining target specific PRS with PRSs of comorbid traits can improve the classification of the target disorders. …”
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Impact of stain variation and color normalization for prognostic predictions in pathology by Siyu Lin, Haowen Zhou, Mark Watson, Ramaswamy Govindan, Richard J. Cote, Changhuei Yang

“…We found that the DNN trained on either batch of slides/images was unable to generalize and failed to predict progression in the other batch of slides/images (AUCcross-batch = 0.52 - 0.53 compared to AUCsame-batch = 0.74 - 0.81). …”
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The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism by Simo Liu, Yaxin An, Bin Cao, Rongxin Sun, Jing Ke, Dong Zhao

“…Methods. We performed a cross-sectional study, including 45 HT patients with euthyroidism, 18 HT patients with hypothyroidism, and 34 healthy controls. …”
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E-Cigarette Quality Control: Impurity and Nicotine Level Analysis in Electronic Cigarette Refill Liquids by Ismail Bennani, Madiha Alami Chentoufi, Miloud El Karbane, Amine Cheikh, Mustapha Bouatia

“…Finally, we used linear regression test to determine the relationship between the nicotine level accuracy on the packaging and the level of toxic impurities in the products. …”
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Analysis of a novel method for finding solutions of interval game problems via fuzzy approaches by Monika Bisht, Shivam Rawat, Junaid Ahmed

“…Therefore, in the present study, we propose a novel method to find solutions to game problems with interval payoffs, utilizing the fuzzy concept. …”
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Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain by Xiaojie Yue, Lei Zhu, Zhigang Zhang

“…Notably, we highlight the <i>App</i> gene, where Lacidofil^® precisely regulated the splicing of two exons causally involved in amyloid β protein-based neurodegenerative diseases. …”
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Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population by Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, K C Vasanthakumar, Kiran Haridas, Vitthal Khode, Anil Bargale

“…There are no reports of HLA B genotype association to South Indian AS patients. In the current study, we have analyzed the HLA-B genotype association with 105 AS patients and 100 respective controls, we have also verified whether any specific clinical manifestation of AS has any pattern of HLA-B subtype association. …”
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A hybrid setup for rodent hyperpolarized metabolic imaging using a clinical magnetic resonance scanner by Ditte Bentsen Christensen, Ingeborg Sæten Skre, Jan Henrik Ardenkjær-Larsen, Mor Mishkovsky, Mathilde H Lerche

“…The system enables 13C dynamic imaging, which we illustrate with detection of hyperpolarized [1–13C]pyruvate and its metabolites in the mouse brain. …”
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Plantar sensation associates with gait instability in older adults by Jason R. Franz, Andrew D. Shelton, Kota Z. Takahashi, Jessica L. Allen

“…Conclusions We conclude that there is an association between worse plantar sensation and gait instability, both during habitual unperturbed walking and in response to some perturbation contexts. …”
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Splenic Artery Pseudoaneurysm Presenting as Massive Hematemesis: A Diagnostic Dilemma by Peeyush Varshney, Bhupen Songra, Shivank Mathur, Sudarshan Gothwal, Puneet Malik, Mahnedra Rathi, Rajveer Arya

“…We performed splenectomy with repair of the defect in the stomach wall and necrosectomy. …”
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Savoirs médicinaux interspécifiques et interactions entre cornacs et éléphants dans le district de Thongmyxay au Laos by Jean-Marc Dubost, Eric Deharo, Sysay Palamy, Chithdavone Her, Chiobouaphong Haekovilay, Lamxay Vichith, Sébastien Duffilot, Sabrina Krief

“…The mahouts and the elephants of Thongmyxay district in Laos form an original hybrid community composed of humans and an animal species represented by both wild and domestic animals (elephants). We investigated in particular the interactions between mahouts' observation of elephants and their own medicinal practices (human and ethnoveterinary), which have been the subject of two previous publications. …”
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A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes. by Marcus K Taylor, Lisa M Hernández, Richard C Allsopp, John J Fraser

“…We also explored whether rs737865 modulated the influence of trauma exposure. …”
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