Effectiveness of educational interventions to promote safe handling of pesticides: protocol for a systematic review and meta-analysis by Anne Cockcroft, Neil Andersson, Sergio Paredes-Solís, José Legorreta-Soberanis, Belén Madeline Sánchez-Gervacio, Víctor Manuel Alvarado-Castro, Miguel Flores-Moreno, Claudia Erika Rios-Rivera, Janet Saldaña-Almazán

“…We will consider randomised and non-randomised controlled trials that evaluated the impact of educational interventions among farmers about the safe use of pesticides. …”
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A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential by M. P. Ponomarenko, I. V. Chadaeva, P. M. Ponomarenko, A. G. Bogomolov, D. Yu. Oshchepkov, E. B. Sharypova, V. V. Suslov, A. V. Osadchuk, L. V. Osadchuk, Yu. G. Matushkin

“…Here, we applied this model to 68 human genes whose changes in expression alter the reproductive health of women and men and to 3080 DEGs of domestic versus wild animals. …”
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Effects of oxidative weathering on Raman spectra of charcoal and bone chars: consequences in archaeology and paleothermometry by Deldicque, Damien, Rouzaud, Jean-Noël, Vandevelde, Ségolène, Medina-Alcaide, Maria Ángeles, Ferrier, Catherine, Perrenoud, Christian, Pozzi, Jean-Pierre, Cabanis, Manon

“…We successfully apply this new tool to charred hearth residues of the Bruniquel cave (France).…”
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Assessing the suitability of sites near Pine Island Glacier for subglacial bedrock drilling aimed at detecting Holocene retreat–readvance by J. S. Johnson, J. Woodward, I. Nesbitt, K. Winter, S. Campbell, K. A. Nichols, R. A. Venturelli, S. Braddock, B. M. Goehring, B. Hall, D. H. Rood, G. Balco, G. Balco

“…Based on our experiences during this study, we conclude with a series of recommendations for assessing site suitability for future bedrock drilling campaigns. …”
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Gene prediction of immune cells association between gut microbiota and colorectal cancer: a Mendelian randomization study by Yan Zhong, Guanglei Chen, Menglu Chen, Junsong Cui, Qianren Tan, Zhenghua Xiao

“…Additionally, we employed MR-Egger Intercept to mitigate the influence of horizontal pleiotropy. …”
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Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses by Bin Zhao, Dan Wang, Yanling Liu, Xiaohong Zhang, Zheng Wan, Jinling Wang, Ting Su, Linshan Duan, Yan Wang, Yuehua Zhang, Yilin Zhao

“…Results. We identified 17 module genes and 6 types of significantly changed immune cells. …”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…We explored the role of TYRO3 using mouse engrafting MC38 or 4T1 tumors. …”
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Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts by Sara Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone, M V Iorio

“…Moreover, we observed that this miRNA is also secreted by fibroblasts and in turn able to alter tumor cell behavior, by modulating its direct target E-cadherin, and NFs themselves. …”
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Ecological networks construction and optimization in the Longdong Loess Plateau: The advantages of self-organizing map and complex networks by Xueyu Huang, Lina Xiu, Zhixiang Lu, Jiahui Wang

“…Furthermore, we compared the ENs before and after optimization to identify the benefits of the SOM. …”
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…We found that with higher altitude, TBI-induced neurological deficits were more severe and the associated histopathological changes were more significant. …”
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The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis by Yi-Zuo Song, He-Yi You, Zhe-Hui Zhu, Zheng-De Wen, Hui-Ying Xu, Bi-Cheng Chen, Zong-Jing Chen, Qing-Ke Huang

“…Methods. We searched different databases including PubMed, EMBASE, CNKI, and the Ovid Library to gather eligible studies on GNB3 polymorphisms and FD. …”
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Development of Evidence-Based COVID-19 Management Guidelines for Local Context: The Methodological Challenges by Sarah Nadeem, Salima Saleem Aamdani, Bushra Ayub, Nashia Ali Rizvi, Fatima Safi Arslan, Russell Seth Martins, Maria Khan, Syed Faisal Mahmood

“…Methods. We conducted a systematic review synthesizing global research on treatment options for COVID-19 hospitalized patients, limiting it to pharmacological interventions for hospitalized COVID-19 patients included in Pakistan’s NCOC’s national guidelines v4 published on 11th December 2020. …”
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Physically based modelling of glacier evolution under climate change in the tropical Andes by J. D. Mackay, J. D. Mackay, N. E. Barrand, D. M. Hannah, E. Potter, E. Potter, N. Montoya, W. Buytaert

“…Only by forcing the model with observed net radiation variables were we able to capture observed surface albedo dynamics. …”
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Daily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients by Hidetaka Matsuda, Takuto Nosaka, Yu Akazawa, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto

“…Introduction. We retrospectively examined the relationship between daily proton pump inhibitor (PPI) use and severity of upper gastrointestinal bleeding (UGIB), mainly in the elderly. …”
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Fine-scale satellite-based monitoring of temperature and vegetation cover in microclimates, distribution ranges, and landscape connectivity for Neurergus kaiseri (Kaiser’s mountain... by Peyman Karami, Sajad Tavakoli, Mina Esmaeili

“…We calculated LST and NDVI trends with MK for sub-basins in suitable habitats, examining significant changes by land use/land cover (LULC). …”
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Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements by Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu

“…CDC37 binds to the kinase C-lobe, mimicking the N-lobe with its HxNI motif. We also describe structures of HSP90 dimers without RAF1 and CDC37, displaying only N-terminal and middle domains, which we term the semi-open state. …”
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Macroecological predictors to determine future refuges of Luciobarbus species in the Tigris–Euphrates basin: Rethinking conservation strategies and management by Hadi Khoshnamvand, Seyed Mohsen Mousavi, Asef Darvishi, Kourosh Ahmadi, Amir Naghibi, Karel Janko, Asghar Abdoli, Faraham Ahmadzadeh

“…Hence, by identifying the regions that will be most affected by climate change in the future, managers can implement more efficient and effective measures to protect them. In this study, we utilized six Luciobarbus species residing at the southernmost boundary of their global distribution as a representative species model. …”
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Which variables are associated with recruitment failure? A nationwide review on obstetrical and gynaecological multicentre RCTs (2003–2023) by Ben W Mol, Madelon van Wely, L Ramos, J J Duvekot, J B Derks, Fulco van der Veen, Ruben Duijnhoven, H J van Beekhuizen, M J E Mourits, J A M van der Post, E Pajkrt, M A Oudijk, H C J Scheepers, Mariette Goddijn, J Huirne, Marijke C van der Weide, A Kwee, C Willekes, M Y Bongers, Judith Rikken, Romee Casteleijn, S Middeldorp, I M Custers, M P Lambregtse – van den Berg, V Mijatovic, F J M Broekmans, A Hoek, J P de Bruin, M H Mochtar, S Mastenbroek, J P W R Roovers, F Mol, A Vollebregt, C H van der Vaart, K B Kluivers, M E Vierhout, R C Painter, P M A J Geomini

“…Objective We aim to assess which variables are associated with recruitment failure of obstetrical and gynaecological randomised controlled trials (RCTs), leading to an extension of the study period.Design Nationwide study.Setting A cohort of RCTs supported by the trial centre of the Dutch Consortium of Obstetrics and Gynaecology.Population We included 83 RCTs that recruited patients between 1 March 2003 and 1 December 2023.Main outcome measures Main outcome was recruitment target not achieved within 6 months after the preplanned recruitment period. …”
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Development of the therapeutic regimen based on the synergistic activity of cyclophosphamide and double-stranded DNA preparation which results in complete cure of mice engrafted wi... by E. A. Potter, E. V. Dolgova, A. S. Proskurina, Ya. R. Efremov, O. S. Taranov, V. P. Nikolin, N. A. Popova, T. D. Dubatolova, D. D. Petrova, E. I. Vereschagin, A. M. Minkevich, O. M. Andrushkevich, S. I. Baiborodin, V. A. Rogachev, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Following CP treatment and massive apoptosis of committed cancer cell subpopulation, we observed relative increase in TISC percentage, which is consistent with reduced susceptibility of TISCs to CP. …”
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Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis by Shixuan Liu, Ceryl Tan, Chloe Melo-Gavin, Miriam B Ginzberg, Ron Blutrich, Nish Patel, Michael Rape, Kevin G Mark, Ran Kafri

“…We found that protein synthesis rates scale proportionally with cell size across cell cycle stages and experimental conditions. …”
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