CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation by Jie Zhang, Jun Pei, Chengjun Yu, Jin Luo, Yifan Hong, Yi Hua, Guanghui Wei

“…Hub genes were searched in the HPA database to confirm their expression. Finally, we construct the interaction network of transcription factor (TF)-Hub genes and miRNA-Hub genes. …”
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Reflections by a member of the Editorial Board by Kevin T. Smith

“…We found that our combination of research experience both intensified and broadened our understanding and presentation of wood structure and function. …”
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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…We profiled 76 primary tumors, 27 adjacent histologically normal kidney samples, and 86 metastases, including 24 brain metastases.Results We observed lower immune checkpoint (TIM-3 and CTLA-4), cytolytic (GZMA and GZMB), and T cell activation (CD25) protein expression in metastases compared with primary tumors in two separate cohorts. …”
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Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress by David Goich, Amanda L. M. Bloom, Sean R. Duffy, Maritza N. Ventura, John C. Panepinto

“…Finally, we implicate this phenomenon in another Hog1-regulated process, morphogenesis, and recapitulate Hog1–Gcn2 crosstalk in the distantly related fungal pathogen, Candida albicans. …”
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Historical snow measurements in the central and southern Apennine Mountains: climatology, variability, and trend by V. Capozzi, F. Serrapica, A. Rocco, C. Annella, C. Annella, G. Budillon

“…Subsequently, focusing on the number of days with snowfall and snow cover duration on the ground, we have carried out a linear trend analysis, employing the Theil–Sen estimator and the Mann–Kendall test. …”
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Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status by S. Nooij, N. Plomp, I. M. J. G. Sanders, L. Schout, A. E. van der Meulen, E. M. Terveer, J. M. Norman, N. Karcher, M. F. Larralde, R. H. A. M. Vossen, S. L. Kloet, K. N. Faber, H. J. M. Harmsen, G. F. Zeller, E. J. Kuijper, W. K. Smits, Q. R. Ducarmon

“…By surveying 12,791 gut metagenomes, we recapitulated known associations with metabolic diseases and inflammatory bowel disease. …”
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Time-resolved Hubble Space Telescope UV Observations of an X-Ray Quasiperiodic Eruption Source by T. Wevers, M. Guolo, S. Lockwood, A. Mummery, D. R. Pasham, R. Arcodia

“…We detect a bright UV point source ( L _FUV ≈ few × 10 ^41 erg s ^−1 ) that does not show statistically significant variability between the X-ray eruption and quiescent phases. …”
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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…Moreover, we constructed a radiogenomic signature based on the ERS. …”
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Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study by Yoshihide Inayama, Ken Yamaguchi, Kayoko Mizuno, Sachiko Tanaka-Mizuno, Ayami Koike, Nozomi Higashiyama, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Junzo Hamanishi, Satomi Yoshida, Masaki Mandai, Koji Kawakami

“…We collected data between April 2014 and September 2021 and analyzed them. …”
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A Pilot Study of Exosome Proteomic Profiling Reveals Dysregulated Metabolic Pathways in Endometrial Cancer by Feras Kharrat, Valeria Capaci, Andrea Conti, Valentina Golino, Pietro Campiglia, Nour Balasan, Michelangelo Aloisio, Danilo Licastro, Lorenzo Monasta, Federica Caponneto, Antonio Paolo Beltrami, Federico Romano, Giovanni di Lorenzo, Giuseppe Ricci, Blendi Ura

“…Through this analysis, we identified 49 metabolic and catabolic pathways related to tumor growth. …”
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Establishing primary care physician commitment in Canadian long-term care homes: a protocol for a modified e-Delphi study by Andrew P Costa, Aaron Jones, Darly Dash, Paula Rochon, Patrick Quail, Rachel D Savage, Henry Yu-Hin Siu, Lisa M McCarthy, Nathan Stall, Dee Tripp, Maya Potter, Paul Katz, Samantha Peck

“…We will recruit pan-Canadian experts who demonstrate extensive knowledge and experience in medical care delivery and medical practice models in the Canadian LTC sector. …”
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Stochastic population models to identify optimal and cost‐effective harvest strategies for feral pig eradication by Peter W. Hamnett, Frédérik Saltré, Brad Page, Myall Tarran, Matt Korcz, Kate Fielder, Lindell Andrews, Corey J. A. Bradshaw

“…We built functional‐response models to calculate annual effort and cost for six cull scenarios across all harvest rates. …”
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Impaction bone grafting for acetabular bone defects replacement in revision hip arthroplasty: biomechanical aspects by Vadim N. Golnik, Natalia V. Fedorova, Alexey Y. Larichkin, Svetlana V. Boyko, Andrey A. Panchenko, Alexandr M. Kosinov, Vladimir A. Peleganchuk, Vitaliy V. Pavlov

“…Taking into account the presence of blood in the wound, we provided for a model with an aqueous solution of 45% glycerin. …”
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Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses by Giorgio Ivan Russo, Maria Giovanna Asmundo, Andrea Cocci, Ali Saber Abdelhameed, Annalisa Liprino, Filippo Giacone, Debora Lombardo, Antonino Guglielmino, Sandrine Chamayou

“…Conversely, in the population of patients with sperm abnormality, we found a significant trend increase from day 1 to day 7 of TSC (16.38 vs. 56.0; p<0.01), sperm concentration (million/ml) (8.0 vs. 18.0; p<0.01) and morphology (3.0 vs. 5.0; p<0.01). …”
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« Pas de retour à nos maisons sans satisfaction de nos revendications ». Le Hirak du Rif en actes face au Makhzen by Ahmed Chapi

“…To provide empirical evidence, we have selected several protest sequences that appeared to us as bifurcation moments. …”
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Synthesis of acrylonitrile functionalized hydroxymethylfurfural derivatives with Mg(OH)$_{{2}}$ under solvent-free conditions by Mancipe, Sonia, Coca, Valentina, Castillo, Juan-Carlos, Rojas, Hugo, Brijaldo, María Helena, Castañeda, Claudia, Martínez, José Jobanny, Romanelli, Gustavo Pablo

“…Specifically, we evaluated the Knoevenagel reaction between HMF and malononitrile as a test reaction under solvent-free conditions. …”
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Interstellar Pickup Ion Observations to 60 au by D. J. McComas, B. L. Shrestha, G. Livadiotis, J. R. Szalay, E. J. Zirnstein, H. A. Elliott, P. C. Brandt, A. R. Poppe, K. N. Singer, A. Stern, A. Verbiscer, the New Horizons Heliophysics Team

“…We find that the fraction of PUIs to all ions in the solar wind continues to grow, reaching ∼18% by 60 au and extrapolated to be ∼30% at 90 au. …”
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Evolution within a given virulence phenotype (pathotype) is driven by changes in aggressiveness: a case study of French wheat leaf rust populations by Fontyn, Cécilia, Meyer, Kevin JG, Boixel, Anne-Lise, Delestre, Ghislain, Piaget, Emma, Picard, Corentin, Suffert, Frédéric, Marcel, Thierry C, Goyeau, Henriette

“…Within these two pathotypes, we identified two main genotypes that emerged in succession. …”
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Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial by Djawid Hashemi, Ludwig Dettmann, Tobias D. Trippel, Volker Holzendorf, Johannes Petutschnigg, Rolf Wachter, Gerd Hasenfuß, Burkert Pieske, Antonia Zapf, Frank Edelmann

“…Abstract Aims Although heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause for hospitalization, its overall costs remain unclear. Therefore, we assessed the health care‐related costs of ambulatory HFpEF patients and the effect of spironolactone. …”
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Data-driven Dynamics with Orbital Torus Imaging: A Flexible Model of the Vertical Phase Space of the Galaxy by Adrian M. Price-Whelan, Jason A. S. Hunt, Danny Horta, Micah Oeur, David W. Hogg, Kathryn Johnston, Lawrence Widrow

“…We release an open-source tool, torusimaging , to accompany this article.…”
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