Pan-cancer and experimental analyses reveal the immunotherapeutic significance of CST2 and its association with stomach adenocarcinoma proliferation and metastasis by Dan Huang, Jing Li, Zhijun He, Wenjing Liang, Likun Zhong, Jun Huang, Yinteng Wu, Shijian Zhao

“…We utilized gene set enrichment analysis (GSEA) analysis to explore the biological functions of CST2 across different cancer types. …”
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Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice by Jing Xue, Yu Cheng, Haojie Hao, Jieqing Gao, Yaqi Yin, Songyan Yu, Junyan Zou, Jiejie Liu, Qi Zhang, Yiming Mu

“…Methods. We induced a T2D mice model by high-fat diets and streptozotocin (STZ) injection. …”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…Accurate diagnosis remains challenging due to low culture positivity rates, frequent polymicrobial involvement, and non-specific diagnostic biomarkers. Here, we undertook a prospective study examining the feasibility and performance of molecular methods for diagnosing suspected pleural infection. …”
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Unveiling Low-frequency Eclipses in Spider Millisecond Pulsars Using Wideband GMRT Observations by Sangita Kumari, Bhaswati Bhattacharyya, Devojyoti Kansabanik, Rahul Sharan, Ankita Ghosh, Jayanta Roy

“…Moreover, for the first time, we detected an eclipse at a nonstandard orbital phase (∼0.5) for PSR J1810+1744, with a duration longer than the eclipse observed at superior conjunction. …”
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Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…We provide practical guidance for approaches to enhance decision-making in future health crises that could also be used for other emergencies.…”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…We further reveal that the α-syn aggregate clearance induced by aspirin is K63-ubiquitination dependent in both cells and PD mice. …”
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D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes by Jialiang Luo, Tianxing Wu, Jing Zhang, Zhicheng Liang, Weijie Shao, Di Wang, Lei Li, Daming Zuo, Jia Zhou

“…The expression of the AMPK/Nrf2/HO-1 signaling-related molecules was determined by Western blotting. Results We first found that topical supplementation of D-mannose remarkably improved skin wound healing in diabetes mice. …”
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Value Propositions for Digital Shared Medication Plans to Boost Patient–Health Care Professional Partnerships: Co-Design Study by Benjamin Bugnon, Francesca Bosisio, Alain Kaufmann, Pascal Bonnabry, Antoine Geissbuhler, Christian von Plessen

“…The multidisciplinary research team included 5 patients as co-researchers. We recruited polypharmacy patients, family caregivers, and health care professionals with a broad range of experiences, diseases, and ages. …”
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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…We further investigated the impact of DBF4 on the progression of ccRCC cells. …”
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Seasonal Changes in Sleep Duration in African American and African College Students Living In Washington, D.C. by Janna Volkov, Kelly J. Rohan, Samina M. Yousufi, Minh-Chau Nguyen, Michael A. Jackson, Courtney M. Thrower, John W. Stiller, Teodor T. Postolache

“…In this study of African and African American college students, we hypothesized that students who met criteria for winter SAD or subsyndromal SAD (S-SAD) would report sleeping longer in winter than in summer. …”
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Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge by M. Biddle, P. Stylianou, M. Rekas, A. Wright, J. Sousa, D. Ruddy, M. I. Stefana, K. Kmiecik, A. Bandrowski, R.A. Kahn, C. Laflamme, E. M. Krockow, H.S. Virk

“…We conclude with an open invitation for stakeholders, including researchers, to join our cause.…”
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Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries: Protocol for a Systematic Review and Meta-Analysis by Maria Beatriz Mourato, Nuno Pratas, Andreia Branco Pereira, Filipa Taré, Raphael Chança, Inês Fronteira, Rui Dinis, Miguel Areia

“…No systematic reviews on GC endoscopic screening in IR countries exist. ObjectiveWe aimed to determine the effectiveness of endoscopic GC screening in IR countries. …”
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Economic evaluation of a randomized controlled trial comparing mifepristone and misoprostol with misoprostol alone in the treatment of early pregnancy loss. by Charlotte C Hamel, Marcus P L M Snijders, Sjors F P J Coppus, Frank P H A Vandenbussche, Didi D M Braat, Eddy M M Adang

“…In this cost-effective analysis we measured the direct, medical costs related to treatment (planned and unplanned hospital visits, medication, additional treatment) and indirect costs based on the IMTA Productivity Cost Questionnaire (iPCQ). …”
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Global variation in the assessment of psychological trauma in pregnancy by Kathryn Wall, Francesca Penner, Lindsey Wallace Goldman, Jin Young Shin, Eloise Novak, Amanda Lowell, Michèle Day, Lea Papa, Drew Wright, Soudabeh Givrad, Helena J. V. Rutherford

“…To better understand trends in how and what kinds of psychological trauma are assessed globally, we conducted a secondary analysis on a larger systematic review examining psychological trauma measurement in pregnancy. …”
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Economic and relationship-strengthening intervention to reduce alcohol use in couples living with HIV in Malawi: a study protocol for a randomised controlled trial of Mlambe by Torsten B Neilands, Lynae A Darbes, James Mkandawire, Derek S Brown, Fred M Ssewamala, Judith A Hahn, Amy A Conroy, Nancy Mulauzi, Scott Tebbetts

“…We will conduct a full-scale, randomised controlled trial (RCT) to evaluate the efficacy and cost-effectiveness of Mlambe.Methods and analysis We will enrol 250 adult married couples having at least one partner living with HIV and reporting heavy alcohol use. …”
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Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…To explore the cellular impact of ATBC, we performed in vitro experiments using osteoblasts (MC3T3-E1) exposed to relevant concentrations. …”
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Reproducibility and Consistency of Isolation Protocols for Fibroblasts, Smooth Muscle Cells, and Epithelial Cells from the Human Vagina by Jayson Sueters, Rogier Schipperheijn, Judith Huirne, Theo Smit, Zeliha Guler

“…We further identified inconsistencies and irreproducible methods for isolation of VECs and SMCs. …”
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O multiculturalismo e as divergências teóricas no debate multicultural by Willian Martini

“…We will explore some of the approaches that arise in multiculturalism, which may contain some ethnocentric aspects.. …”
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Analysis of serum levels and DNA methylation of fibroblast growth factor 21 using peripheral blood-derived genomes in patients with obesity by Hiroyuki Shinozaki, Shiori Kawai, Mami Gamo-Kawasaki, Ayano Takei, Kyoko Tsujikado, Kazunori Fukuda, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Koshi Hashimoto

“…Furthermore, we found that the DNA methylation state of Fgf21 was involved in obesity in adult animals. …”
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The Generation and Modulation of Distinct Gamma Oscillations with Local, Horizontal, and Feedback Connections in the Primary Visual Cortex: A Model Study on Large-Scale Networks by Chuanliang Han, Tian Wang, Yujie Wu, Yang Li, Yi Yang, Liang Li, Yizheng Wang, Dajun Xing

“…We created a computational model composed of multiple excitatory and inhibitory units with biologically plausible connectivity patterns for RC, FF, FB, and HC in V1; then, we quantitated GAMMA in network models at different strength levels of HC and other connection types. …”
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