ALMA FACTS. II. Large Scale Variations in the 12CO(J = 2 – 1) to 12CO(J = 1 – 0) Line Ratio in Nearby Galaxies by Shinya Komugi, Tsuyoshi Sawada, Jin Koda, Fumi Egusa, Fumiya Maeda, Akihiko Hirota, Amanda M. Lee

“…We find that r _21 is systematically higher in outliers compared to the disk. …”
Get full text

CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1–CXCR2 induced NETs by Yu Liang, Shuang Chen, Zhi Chen, Fang Peng, Qianwen Liu, Gan Xiong, Caihua Zhang, Maosheng Cheng, Rongsong Ling, Demeng Chen, Qimin Zhou

“…Moreover, IHC, flow cytometry, and immunofluorescence techniques were employed to measure immune cell proportions in ESCC. In addition, we conducted single-cell RNA sequencing analysis to examine the alterations in tumor microenvironment following CD276 depletion.Results In this study, we elucidate that CD276 is markedly upregulated in ESCC, correlating with poor prognosis. …”
Get full text

From α-to β-diversity: Understanding the historical, present, and future diversity patterns of Fagaceae in Southwestern China by Bikram Pandey, Fengying Zhang, Basu Dev Poudel, Rong Li, Mohammed A. Dakhil, Bishal Gurung, Zhaxi Luobu, Yawen Gan, Ziyan Liao, Lin Zhang

“…We modeled the α-diversity via stacking prediction using an individual species distribution model at 50 km × 50 km grid cells. …”
Get full text

Candidate SNP-markers altering TBP binding affinity for promoters of the Y-linked genes CDY2A, SHOX, and ZFY are lowering many indexes of reproductive potential in men by M. P. Ponomarenko, E. B. Sharypova, I. A. Drachkova, L. K. Savinkova, I. V. Chadaeva, D. A. Rasskazov, P. M. Ponomarenko, L. V. Osadchuk, A. V. Osadchuk

“…As a result, we found 11 candidate SNP markers for MRP, which can significantly alter the TATA-binding protein (TBP) binding affinity for promoters of these genes. …”
Get full text

Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary col... by Policar, Clotilde, Delsuc, Nicolas, Bertrand, Hélène Charlotte

“…Bioinorganic chemistry and inorganic chemical biology are multidisciplinary fields dealing with metal ions in biological systems. In this article we will describe a research journey in these fields. …”
Get full text

Perspectives of Hispanic and Latinx Community Members on AI-Enabled mHealth Tools: Qualitative Focus Group Study by Stephanie A Kraft, Shaan Chopra, Miriana C Duran, Janet A Rojina, Abril Beretta, Katherine I López, Russell Javan, Benjamin S Wilfond, Margaret Rosenfeld, James Fogarty, Linda K Ko

“…ResultsBetween May and September 2023, we conducted 8 focus groups in English or Spanish with 48 participants. …”
Get full text

Immunogenetics of longevity and its association with human endogenous retrovirus K by Lisa M. James, Lisa M. James, Lisa M. James, Apostolos P. Georgopoulos, Apostolos P. Georgopoulos, Apostolos P. Georgopoulos, Apostolos P. Georgopoulos

“…Furthermore, we identified 13 HLA alleles (9 HLA-I and 4 HLA-II) that occurred at greater frequency in very old individuals (age ≥90 years) as compared to younger individuals. …”
Get full text

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer by Xiang Pan, Kailai Chen, Wei Gao, Meiqi Xu, Fanlong Meng, Mengyuan Wu, Zi Qi Wang, Yun Qi Li, Wanhai Xu, Manjie Zhang, Yakun Luo

“…Results We identified a novel tumor-suppressive circRNA, circBNC2, in human PCa, CRPC and NEPC samples via bioinformatic analysis. …”
Get full text

Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

“…We find that hydraulic gradient, topographic gradient, hydraulic conductivity, and aquifer depth are important controls in different places. …”
Get full text

Contribution of type 2 diabetes to major adverse cardiovascular events (MACE) in a long-term observational study with different stages of atherosclerosis by Arthur Mader, Dario Haeberli, Barbara Larcher, Jörn F. Dopheide, Christoph H. Saely, Christine F. Heinzle, Peter Amann, Marc Schindewolf, Andreas Festa, Heinz Drexel

“…We included 1238 patients from two prospective, long-term cohort studies. …”
Get full text

3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study by Julia Napp, Götz Gelbrich, Floran Sahiti, Vladimir Cejka, Dora Pelin, Lena Schmidbauer, Mengmeng Chen, Niklas Hitschrich, Marcus Schreckenberg, Stefan Frantz, Peter U. Heuschmann, Stefan Störk, Caroline Morbach

“…From a subset of 479 apparently healthy individuals exhibiting no cardiovascular (CV) risk factors or CV disease (mean age 52 ± 10 years, 56.4% women), we derived reference percentiles for twist and torsion. …”
Get full text

O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…We found a time-dependent dynamic alteration in lung O-GlcNAcylation during I/R injury. …”
Get full text

Crystalloid resuscitation is associated with decreased treatment delays and improved systolic blood pressures in a blood-constrained setting by Melissa Carvalho, Alain Chichom-Mefire, Catherine Juillard, S Ariane Christie, Rasheedat Oke, Thompson Kinge, Jean-Gustave Tsiagadigui, Mbiarikai A Mbianyor, Mark T Yost, Matt Driban, Fanny Nadia Dissak Delon, Richard Njock, Daniel Nkusu

“…Objectives We analyzed resuscitation practices in Cameroonian patients with trauma as a first step toward developing a context-appropriate resuscitation protocol. …”
Get full text

Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank by Monika Kasper-Sonnenberg, Claudia Pälmke, Sonja Wrobel, Thomas Brüning, Aline Murawski, Petra Apel, Till Weber, Marike Kolossa-Gehring, Holger M. Koch

“…The German Environmental Specimen Bank (ESB) annually archives 24-h urine samples since the early 1980s. In this study, we analyzed 420 of these samples from the years 2014 to 2022 for metabolites of 18 phthalates and two substitutes. …”
Get full text

Healthcare practitioners as accomplices: a qualitative study of gender affirmation in a context of ambiguous regulation in Indonesia by Benjamin Hegarty, Alegra Wolter, Amalia Puri Handayani, Kevin Marian, Jamee Newland, Dede Oetomo, Ignatius Praptoraharjo, Angela Kelly-Hanku

“…In light of the challenges associated with medical and legal gender affirmation in Indonesia, we conducted a qualitative study to understand the views of trans people, healthcare providers, and legal practitioners. …”
Get full text

Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…Methods: We performed bisulfite sequencing based promoter methylation analysis with or without treatment with DNA methyl transferase (DNMT) inhibitor 5-Aza-2′-deoxycytidine (AzaC). …”
Get full text

The Effect of Temperature over the Growth and Biofilm Formation of the Thermotolerant <i>Aspergillus flavus</i> by José Alejandro Hernández-Benítez, Brenda Nallely Santos-Ocampo, Daniel Genaro Rosas-Ramírez, Luis Antonio Bautista-Hernández, Víctor Manuel Bautista-de Lucio, Néstor Octavio Pérez, Aída Verónica Rodríguez-Tovar

“…We examined biofilm formation in both strains across different temperatures and evaluated the susceptibility of this <i>A. flavus</i> isolate to antifungal agents in both planktonic and biofilm form. …”
Get full text

Formation of Stripped Stars from Stellar Collisions in Galactic Nuclei by Charles F. A. Gibson, Fulya Kiroğlu, James C. Lombardi Jr., Sanaea C. Rose, Hans D. Vanderzyden, Brenna Mockler, Monica Gallegos-Garcia, Kyle Kremer, Enrico Ramirez-Ruiz, Frederic A. Rasio

“…We conclude that high-velocity stellar collisions can form products that have abundance ratios similar to those observed in the motivating TDEs. …”
Get full text

The protein structurome of Orthornavirae and its dark matter by Pascal Mutz, Antonio Pedro Camargo, Harutyun Sahakyan, Uri Neri, Anamarija Butkovic, Yuri I. Wolf, Mart Krupovic, Valerian V. Dolja, Eugene V. Koonin

“…We used protein structure modeling and similarity searches to illuminate the remaining dark matter in hundreds of thousands of orthornavirus genomes. …”
Get full text

CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…We used phage display libraries of 23ME–00610 variants with individual CDR residues randomized to all 20 amino acids, from which we identified mutations that switched on MfCD200R1 binding. …”
Get full text