Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis by Zhihui Yu, Lingyu Fan, Fei Tai, Lixin Zhang, Xiaoyu Zhang, Yisheng Chen

“…Mice were divided into five groups (n=8): normal diet group (ND), high-fat diet group (HFD), HFD with whole egg group (WE), HFD with free-yolk egg substitute group (YFES), and HFD with lovastatin group (Lov). …”
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iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study by Peter D. Westenskow, Felicitas Bucher, Stephen Bravo, Toshihide Kurihara, Daniel Feitelberg, Liliana P. Paris, Edith Aguilar, Jonathan H. Lin, Martin Friedlander

“…In this follow-up study, we longitudinally monitored the same implanted iPS-RPE, in the same animals. …”
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Peroxisome Proliferator-Activated Receptor γ Regulates Lipid Metabolism in Sheep Trophoblast Cells through mTOR Pathway-Mediated Autophagy by Kexing Hao, Jing Wang, Hengbin Yu, Lei Chen, Weibin Zeng, Zhengrong Wang, Guangdong Hu

“…In this study, we used PPARγ agonist rosiglitazone and inhibitor GW9662, as well as autophagy activator rapamycin and inhibitor 3-methyladenine, to unravel the probable mechanism of PPARγ engaged in lipid metabolism in sheep trophoblast cells (STCs). …”
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Long term adult visual plasticity after the developmental critical period in genetically determined peripheral visual loss by Otília C. d’Almeida, Joana M. Sampaio, Sónia Ferreira, Eduardo D. Silva, Miguel Castelo-Branco

“…We used as outcomes population receptive field measures to probe long-term plasticity using fMRI retinotopy. …”
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Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator by N. L. Podkolodnyy, N. N. Tverdokhleb, O. A. Podkolodnaya

“…We included the additional feedback of the oscillator which concerns genes/proteins NAMPT, SIRT1, and also NAM, NAD+. …”
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Mixed-methods study to examine the response of opioid addiction treatment programmes to COVID-19: a study protocol by Sugy Choi, Rhea Naik, Kamila Kiszko, Charles Neighbors, Thomas D’Aunno

“…For the quantitative aim, we will use the Client Data System and Medicaid claims data to examine the variation in clinical practices (ie, changes in telehealth, pharmacotherapy, group vs individual counselling and urine drug screening) and retention in treatment for OUD patients across 580 outpatient clinics in NYS during the pandemic. …”
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One size does not fit all: revising traditional paradigms for assessing accuracy of QSAR models used for virtual screening by James Wellnitz, Sankalp Jain, Joshua E. Hochuli, Travis Maxfield, Eugene N. Muratov, Alexander Tropsha, Alexey V. Zakharov

“…For this increasingly common task, we now recommend the use of models with the highest positive predictive value (PPV) built on imbalanced training sets as preferred virtual screening tools. …”
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First report of hypoplastic left heart syndrome in 3p- syndrome and review of candidate genes by Ana Kalise Böttcher, Monique Banik Siqueira, Natasha Malgarezi, Marcela Rodrigues Nunes, Rafaella Mergener, Luisa Pigatto Kalil, Patrícia Trevisan, Paulo Ricardo Gazzola Zen

“…Furthermore, we aim to establish a gene-phenotype association. …”
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A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression by Nur Fatinazwa Mohd Faizal, Saptarsi Shai, Bansi P. Savaliya, Lee Peng Karen-Ng, Rupa Kumari, Rahul Kumar, Vui King Vincent-Chong

“…To address this paucity, we aimed to provide comprehensive evidence by recruiting studies that have reported new biomarkers/signatures to establish a prognostic model to predict the survival of OSCC patients. …”
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Effect of a Short, Animated Storytelling Video on Transphobia Among US Parents: Randomized Controlled Trial by Doron Amsalem, Merlin Greuel, Shuyan Liu, Andrés Martin, Maya Adam

“…MethodsWe recruited 1267 US parents, through the Prolific Academic (Prolific) online research platform, and randomized them into video intervention or control groups. …”
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An action research study on the needs and perspectives of medical students and junior residents on peer physical examination guidelines to respect medical students’ autonomy and pr... by Emily Suzuki, Nobutoshi Nawa, Eriko Okada, Yu Akaishi, Ayako Kashimada, Mitsuyuki Numasawa, Kumiko Yamaguchi, Kazuki Takada, Masanaga Yamawaki

“…We then conducted interviews of 16 participants and revised our guidelines accordingly. …”
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Generalising axion-like particle as the curvaton: sourcing primordial density perturbation and non-Gaussianities by Anish Ghoshal, Abhishek Naskar

“…Abstract We investigate the non-perturbatively generated axion-like particle (ALP) potential, involving fermions in the dark sector that couple to the ALP, in an early universe cosmological inflationary stage with the ALP being a spectator field. …”
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The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery by Timea Tänczer, Márk M. Svébis, Beatrix Domján, Viktor J. Horváth, Adam G. Tabák

“…We also sought (3) other determinants of MGR. Research Design and Methods. …”
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Joint Adaptive OFDM and Reinforcement Learning Design for Autonomous Vehicles: Leveraging Age of Updates by Mamady Delamou, Ahmed Naeem, Huseyin Arslan, El Mehdi Amhoud

“…In contrast, the effectiveness of the sensing is assessed using the velocity resolution. In addition, we exploit adaptive OFDM techniques for dynamic modulation, and we suggest a reward function that leverages the age of updates to handle the communication buffer and improve sensing. …”
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A Search for Radio Millisecond Pulsar Companions around Extremely Low-mass White Dwarfs with Ellipsoidal Variability by W. J. Huang, Pak-Hin Thomas Tam, L. L. Ren, J. M. Lin

“…Among them, four targets have companion masses exceeding 1 M _⊙ . We performed a search for radio pulsations from six of these targets by using Five-hundred-meter Aperture Spherical radio Telescope. …”
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Defining New Research Questions and Protocols in the Field of Traumatic Brain Injury through Public Engagement: Preliminary Results and Review of the Literature by Shumaila Hasan, Aswin Chari, Mario Ganau, Chris Uff

“…We proposed various methods of tissue sampling at opportunistic times: two methods rely on a dedicated sample being taken; the remainder relies on tissue that would otherwise be discarded. …”
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Evaluating 36 years of fishing sustainability in a large reservoir by Luiz Guilherme dos Santos Ribas, Pitágoras Augusto Piana, Caroline Henn, Anderson Luís Maciel, Geuza Cantanhêde, Maurício Spagnolo Adames, Éder André Gubiani

“…Consequently, the Itaipu company has monitored artisanal commercial fishing since the formation of its reservoir. In this study, we used long-term monitoring data to evaluate the sustainability of this fishing activity in the Itaipu Reservoir, one of the largest reservoirs in the Neotropical region. …”
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Effects of socioeconomic and human-modified landscape variables on medicinal species richness at a macroscale: the case of the Caatinga, Brazil by Aníbal Silva Cantalice, Thiago Gonçalves-Souza, Ulysses Paulino Albuquerque

“…We compiled and curated data on woody medicinal species from a systematic review encompassing diverse communities across the Caatinga region in North-east Brazil. …”
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Assessment of Self-Activation and Inhibition of Wheat Coiled-Coil Domain Containing NLR Immune Receptor Yr10_CG by Nan Wu, Wanqing Jiang, Zhaoxia Xiang, Raheel Asghar, Mahinur S. Akkaya

“…However, we observed that mutations in the conserved MHD motif, specifically D502G, activated Yr10_CG and induced cell death. …”
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Phytotoxic Effects of Polystyrene Microplastics on Growth Morphology, Photosynthesis, Gaseous Exchange and Oxidative Stress of Wheat Vary with Concentration and Shape by Komal Riaz, Tahira Yasmeen, Kotb A. Attia, Itoh Kimiko, Muhammad Saleem Arif

“…However, little is known about how plants react to microplastics with different concentrations and shapes. To this end, we conducted a factorial pot experiment with wheat (<i>Triticum aestivum</i> L.) in which we mixed polystyrene (PS) in different shapes (bead, fiber and powder) with soil at concentrations of 0, 1, 3 and 5%. …”
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